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The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor

Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1

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Saco-rådet i Umeå kommun, org.nr: 802421-7047 ÅRSMÖTESPROTOKOLL Plats och tid Tisdag den 29 mars 2022, Digitalt via TEAMS, kl. 17.00 – 18.00 Närvarande Saco-medlemmar: Carina Lidgren Heimersson Per Olof Backlund Annika Winning Joakim Åsberg Nina Stenbacka Katharina Radloff Katarina Spetz Lena Svedjehed Karin Berggren Maja Rydlöv Lasse Brännström Birgitta Larsson (fram till §6) § 1 Årsmötets öppnan

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/umea-kommun/dokument/saco-protokoll-arsmote-2022.pdf - 2026-05-15

COVID-19 vaccine effectiveness against severe disease from SARS-CoV-2 Omicron BA.1 and BA.2 subvariants - surveillance results from southern Sweden, December 2021 to March 2022

We compared vaccine effectiveness against severe COVID-19 between December 2021 and March 2022 when Omicron BA.1 and BA.2 were the dominating SARS-CoV-2 variants in Scania county, Sweden. Effectiveness remained above 80% after the transition from BA.1 to BA.2 among people with at least three vaccine doses but the point estimate decreased markedly to 54% among those with only two doses. Protection

Counterintuitive Electrostatics upon Metal Ion Coordination to a Receptor with Two Homotopic Binding Sites

The consecutive binding of two potassium ions to a bis(18-crown-6) analogue of Tröger’s base (BCETB) in water was studied by isothermal titration calorimetry using four different salts, KCl, KI, KSCN, and K2SO4. A counterintuitive result was observed: the enthalpy change associated with the binding of the second ion is more negative than that of the first (ΔH°bind,2 < ΔH°bind,1). This remarkable f

Mathematics and physics at upper secondary school: an analysis of two lectures

A physics lecture and a mathematics lecture, by the same teacher and partly thesame students, were studied at upper secondary school. Both lectures coveredordinary differential equations. The main aim of the present paper was to investigate the teacher’s different and similar ways to handle related mathematicalcontent in the two school subjects. The findings show a structural use of mathematics wi

Translocation of Antimicrobial Peptides across Model Membranes : The Role of Peptide Chain Length

Cushioned lipid bilayers are structures consisting of a lipid bilayer supported on a solid substrate with an intervening layer of soft material. They offer possibilities for studying the behavior and interactions of biological membranes more accurately under physiological conditions. In this work, we continue our studies of cushion formation induced by histatin 5 (24Hst5), focusing on the effect o

Subclassification of obesity for precision prediction of cardiometabolic diseases

Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000). We detected five discordant p

Medical therapy versus transurethral resection of the prostate (TURP) for the treatment of symptomatic benign prostatic enlargement (BPE) : a cost minimisation analysis

Purpose: A cost minimisation analysis compares the costs of different interventions’ to ascertain the least expensive over time. We compared different prostate targeted drug treatments with TURP to identify the optimal cost saving duration of a medical therapy for symptomatic benign prostatic enlargement (BPE). Methods: The Evolution registry is a prospective, multicentre registry, conducted by th

Gas-Phase Anion Exchange for Multisegment Heterostructured CsPb(Br1xClx)3 Perovskite Nanowires

Metal-halide perovskites (MHPs) are promising as active optoelectronic materials for a diverse range of devices. Anion exchange is a post-growth modification of MHP materials that allows tuning of the band gap and crystal structure by exposure to alternative halides, normally using solution methods. Here, low temperature gas-phase anion exchange for the conversion of CsPbBr3 nanowires (NW) into Cs