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A Fecal Metabolite Signature of Impaired Fasting Glucose : Results From Two Independent Population-Based Cohorts

Prediabetes is a metabolic condition associated with gut mi-crobiome composition, although mechanisms remain elu-sive. We searched for fecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individuals with IFG and 1,105 healthy individuals from the UK Adult Twin Registry (TwinsUK). We used the Cooperative Health Research in the Region of Aug

The case for precision medicine in the prevention, diagnosis, and treatment of cardiometabolic diseases in low-income and middle-income countries

Cardiometabolic diseases are the leading preventable causes of death in most geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic diseases vary greatly worldwide, as do the resources and strategies needed to prevent and treat them. Therefore, there is no single solution and health care should be optimised, if not to the individual (ie, personalised health care), the

Understanding diabetes heterogeneity : key steps towards precision medicine in diabetes

Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three d

Acoustic enrichment of heterogenous circulating tumor cells and clusters from patients with metastatic prostate cancer

BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS: Ac

Validation of the Skåne University Hospital nomogram for the preoperative prediction of a disease-free axilla in patients with breast cancer

BACKGROUND: Axillary staging via sentinel lymph node biopsy (SLNB) is performed for clinically node-negative (N0) breast cancer patients. The Skåne University Hospital (SUS) nomogram was developed to assess the possibility of omitting SLNB for patients with a low risk of nodal metastasis. Area under the receiver operating characteristic curve (AUC) was 0.74. The aim was to validate the SUS nomogra

The PROCEM study protocol : Added value of preoperative contrast-enhanced mammography in staging of malignant breast lesions - a prospective randomized multicenter study

Background: Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. The sensitivity of mammography is lower in dense breasts, and additional imaging techniques are sometimes warranted. Contrast-enhanced mammography (CEM) has shown similar sensitivity and in some cases better specificity, than magnetic resonance imaging (MRI) in small, obser

“In a Way We Took the Hospital Home”—A Descriptive Mixed-Methods Study of Parents’ Usage and Experiences of eHealth for Self-Management after Hospital Discharge Due to Pediatric Surgery or Preterm Birth

The costly and complex needs for children with long-term illness are challenging. Safe eHealth communication is warranted to facilitate health improvement and care services. This mixed-methods study aimed to describe parents’ usage and experiences of communicating with professionals during hospital-to-home-transition after their child’s preterm birth or surgery for col-orectal malformations, using

Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19

Objective and design: Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as long-COVID). The mechanisms underlying long-COVID fatigue are unknown. We hypothesized that the development of long-CO

Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA

Prokaryotic Argonaute proteins (pAgos) from the long-A clade are stand-alone immune systems that use small interfering DNA (siDNA) guides to recognize and cleave invading plasmid and virus DNA. Certain long-A pAgos are co-encoded with accessory proteins with unknown functions. Here, we show that cyanobacterial long-A pAgos act in conjunction with Argonaute-associated Cas4 family enzyme 1 (ACE1). S

PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research

Prostate Cancer Diagnosis and Treatment Enhancement through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer. PIONEER brings together 34 private and public stakeholders from 9 countries in one multidisciplinary research consortium with the aim of positively transforming the field of prostate cancer clinical care by answering pressing que

Statin use and risk of breast cancer among women with benign breast disease : a Danish nationwide cohort study

BACKGROUND: Statins have been suggested to protect against breast cancer risk, but the observational evidence is inconclusive. We examined the association between statin use and breast cancer incidence among women at higher risk of breast cancer due to a history of benign breast disease (BBD).METHODS: Using Danish registries, we identified cancer-free women aged ≥50 years during 1996-2018 with a h

Revealing the 1,4-diethynylbenzene SERS activity and docking studies by DFT

Surface-enhanced Raman scattering (SERS) technology can detect molecular information; Because of its high sensitivity, it is widely used in chemical analysis. In this study discussed the experimental detection of 1,4-diethynylbenzene molecule based on SERS technology. The SERS spectra of 1,4-diethynylbenzene molecule were calculated by Density Functional Theory (DFT) simulation, and the results sh

Treatment Trajectories in Metastatic Hormone-sensitive Prostate Cancer : A PIONEER+ Big Data Analysis

BACKGROUND AND OBJECTIVE: The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) is evolving rapidly. Real-world data (RWD) are essential to understand actual treatment use and outcomes. This study aimed to describe treatment trajectories and clinical outcomes in a large, multicenter RWD cohort under the PIONEER project. METHODS: Eight European and US databases (2016-2020

Self-adaptive ZrN coating enables stable acidic oxygen evolution on Co3O4through dynamic surface reconstruction

The development of acid-stable, non-precious catalysts for the oxygen evolution reaction (OER) remains a critical challenge for proton exchange membrane water electrolyzers (PEMWEs). While Co3O4 shows promising OER activity, its rapid dissolution in acidic media severely limits practical application. Here, we design a self-adaptive protection strategy by depositing ZrN coatings on Co3O4 precursor

RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio

Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10 -8) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic pr

ROS activity in carbonaceous nanoparticles : the influence of surface area and chemistry

Carbon Black (CB), graphene, and nanodiamond are distinct carbonaceous insoluble nanoparticles. Reactive Oxygen Species (ROS) associated with these particles play a significant role in both in vivo and in vitro toxicity evaluations. Accurate assessment of ROS activity is relevant for toxicity screening and in ensuring safe working environments as well as guiding the innovation by safe-and-sustaina

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SACO-rådet i Umeå kommun 2022-03-03 KALLELSE TILL SACORÅDETS ÅRSMÖTE 2022 Tid: Tisdagen den 29 mars, kl. 17.00 Plats: Teams Program: Årsmöte Anmälan: Senast 2022-03-28 till Karin Berggren, karin.berggren@umea.se. Sacorådets uppgifter är bland annat att handlägga de frågor som enskilt förbund delegerar och att vara förbundens kontaktorgan i frågor som är av gemensamt och övergripande intresse. Råde

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/umea-kommun/dokument/kallelse-till-saco-radets-arsmote-2022.docx - 2026-05-17

Chalmers-nya-eds-marie-widigson

2024-05-16 ESSUG övergång till nya EDS.pptx Chalmers väg till nya EDS ESSUG Sundsvall 2024-05-16 Marie Widigson Widigson, M. (2024). Artificial Intelligence Art. Microsoft Copilot, DALL·E 3 2005 Sierra OPAC + Summon 2017 Beta-avtal att använda FOLIO med EDS 2018 Sierra OPAC + EDS 2019 FOLIO + EDS All låntagarfunktionalitet för tryckt material enbart i EDS (status, reservationer & omlån) Bra att in

https://www.ub.lu.se/sites/ub.lu.se/files/2024-05/chalmers-nya-eds-marie-widigson.pdf - 2026-05-17

Infektionssjukvayrd fapr sjukskapterskor ht18

I samarbete med Avdelningen för infektionsmedicin, Infektionskliniken vid Skånes univer- sitetssjukhus, (SUS) Lund arrangerar Institutionen för hälsovetenskaper en kurs om infek- tionssjukdomar, deras handläggning och behandling. Kursen vänder sig till sjuksköterskor. KURSENS INNEHÅLL Klinik, diagnostik, behandling och omvårdnad vid bl a följande infektionssjukdomar: • Endokarditer • Hepatiter • H

https://www.medicin.lu.se/sites/medicin.lu.se/files/infektionssjukvayrd_fapr_sjukskapterskor_ht18.pdf - 2026-05-17