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In clinical trials, surrogate endpoints, that are more cost-effective, occur earlier, or are more frequently measured, are sometimes used to replace costly, late, or rare true endpoints. Regulatory authorities typically require thorough evaluation and validation to accept these surrogate endpoints as reliable substitutes. To this end, the meta-analytic framework is considered a very viable approac

Aphids cause massive agricultural losses through direct damage or as pathogen vectors. Control often relies on insecticides, which are expensive and not selective. An interesting alternative is to use aphid sex pheromones nepetalactone (NON) and nepetalactol (NOL) to interfere with aphid mating or attract aphid predators. Here, we explore production of these compounds in plants, as their precursor

Developing an efficient code for large, multiscale astrophysical simulations is crucial in preparing for the upcoming era of exascale computing. RAMSES is an astrophysical simulation code that employs parallel processing based on the message-passing interface (MPI). However, it has limitations in computational and memory efficiency when using a large number of CPU cores. The problem stems from ine

Designing technologies that clothe, adorn, or are otherwise placed on the body raises questions concerning the role they will play in dressing ourselves. We situate self-fashioning - or the process through which we stylise and present our bodies - as a complex practice where a series of social, material, and contextual factors shape how we present ourselves. Informed by reflective discussions and

With this paper and the accompanying audio paper, our aim is to explore the juxtaposition of sound and democracy. Recognizing the multifaceted nature of this field, we approach it through the notion of care and an empirical analysis of democratic implications of trying to regulate sound in public spaces. We examine standards as one example of the many attempts to control sound in both public and p

Cellular-based localization and sensing pave the way for a variety ofapplications across various domains, ranging from autonomous driv-ing to emergency care and intelligent traffic management. Althoughtraditional methods have been effective, they still face challenges such as therequirement for highly accurate models and the inherent complexity of thealgorithms. This thesis explores the potential

This paper discusses the role of fundamental rights in the EU’s legislation on digitalisation, with a particular focus on the proposed Digital Services Act (DSA) and the Digital Markets Act (DMA). As the EU Charter of Fundamental Rights is receiving an increasingly prominent role in regulating the digital sphere in order to rectify the increasing challenges of a ‘wild West’ internet, the constitut

By measuring X-ray emission of the water molecule in liquid phase we establish a first example of K-shell X-ray emission spectra with strong breakdown of the molecular orbital picture. A complete splitting of the 2a1 peak into satellites is observed. A theoretical model with electronic configurations generated by coupled excitations/de-excitations, so-called semi-internal configuration interaction

A 1D imaging soft X-ray spectrometer installed on the small quantum systems (SQS) scientific instrument of the European XFEL is described. It uses movable cylindrical constant-line-spacing gratings in the Rowland configuration for energy dispersion in the vertical plane, and Wolter optics for simultaneous 1D imaging of the source in the horizontal plane. The soft X-ray fluorescence spectro-imaging

The world is suffering from increasing weather extremes caused by climate change of which the building sector is a major contributor. There is however a large reduction potential in the sector and circular economy has received increased attention both within research and practice. This study explores circular futures within the building sector through the futures studies method of backcasting. Two

This article provides a new argument and a new value-theoretical ground for person-centered care and shared decision making that ascribes to it the role of enabling rational choice in situations involving clinical choice. Rather than referring to good health outcomes and/or ethical grounds such as patient autonomy, it argues that a plausible justification and ground for person-centered care and sh

The main objective of this paper is to develop a readiness index model that can serve as an analytical tool for exploring the achievements of the electrification of transportation systems. We have applied this readiness index model to evaluate the readiness positioning of China, Norway, and Sweden towards transportation electrification. We have chosen these three countries as they represent divers

Hydropower is one of the most promising sources of renewable energy. However, a substantial initial investment requires for the construction of large civil structures. Feasibility study, detailed project report preparation, construction planning, and timely execution of work are the important activities of a hydropower plant. Energy generation in hydropower plants are mainly depends on discharge a

Charged particle reconstruction in the presence of many simultaneous proton–proton (pp) collisions in the LHC is a challenging task for the ATLAS experiment’s reconstruction software due to the combinatorial complexity. This paper describes the major changes made to adapt the software to reconstruct high-activity collisions with an average of 50 or more simultaneous pp interactions per bunch cross

The challenge of urbanisation, caused by an increase in city population, is increasing demand for imported food products. Food supplies may be impacted by the exponential increase in food demand caused by a constantly expanding global population. Growing and producing food in urban areas has now become a common practice. Addressing food system challenges through the adoption of urban farms on gree