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Objective: To identify prognostic factors for patients with advanced persistent, recurrent, or 2nd primary oral cavity squamous cell carcinoma (OCSCC) potentially unsuitable for salvage surgery with free tissue flap (FTF) reconstruction. Materials and methods: A population-based cohort of 83 consecutive patients with advanced OCSCC who underwent salvage surgery with FTF reconstruction at a tertiar
IMPORTANCE: Discontinuation and nonpublication are established sources of avoidable waste among surgical trials, but rates of delayed completion and recruiting shortfalls remain unclear.OBJECTIVES: To examine the rate of delayed completion, incomplete enrollment, and discontinuation among randomized clinical trials in surgical populations and the duration of delays and extent of recruiting shortfa
Studies have indicated that transportation noise is associated with higher cardiovascular mortality, whereas evidence of noise as a risk factor for respiratory and cancer mortality is scarce and inconclusive. Also, knowledge on effects of low-level noise on mortality is very limited. We aimed to investigate associations between road and railway noise and natural-cause and cause-specific mortality
INTRODUCTION: The Five Self-Harm Behavior Groupings Measure (5S-HM) is a novel assessment that evaluates behaviours which may go undetected by existing measures. Self-harm is formulated across directness and lethality spectra, including under-studied behaviors such as indirect self-harm, harmful self-neglect and sexual self-harm. Aims of the study were to: (1) empirically evaluate the 5S-HM; (2) t
BACKGROUND: Most cerebral palsy (CP) cases have an unexplained etiology, but a role for environmental exposures has been suggested. One purported environmental risk factor is exposure to endocrine-disrupting pollutants specifically per- and polyfluoroalkyl substances (PFAS).OBJECTIVES: We investigated the association between prenatal PFAS exposures and CP in Swedish children.METHODS: In this case-
Background: Adolescent pregnancy and associated neonatal mortality are major global health challenges. In low-income settings where 90% of the 21 million global adolescent pregnancies occur, half are unintended and a fifth experience unsafe abortion. In Kenya, Uganda, and Tanzania, the survival patterns of neonates born to adolescents are unclear.Objectives: To assess survival patterns among neona
BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrat
Background: Environmental exposures to industrial chemicals, including perfluoroalkyl substances (PFAS), may play a role in bone development and future risk of osteoporosis. However, as prospective evidence is limited, the role of developmental PFAS exposures in bone density changes in childhood is unclear. The objective of this study was to estimate associations between serum-PFAS concentrations
Background: This study aimed to evaluate whether an increasing grade of obesity is associated with inferior outcomes after lumbar disc herniation (LDH) surgery. Methods: We retrieved data from the Swedish register for spine surgery regarding patients aged 20–64 who underwent LDH surgery from 2006–2016 and had preoperative and one-year postoperative data. A total of 4156 patients were normal weight
Background. The urokinase plasminogen activator (uPA) system is involved in tissue remodelling processes and is up-regulated in many types of malignancies. We investigated whether serum levels of different forms of soluble uPA receptor (suPAR) are associated with survival and in particular with prostate cancer and cardiovascular disease mortality. Methods. Using time-resolved fluorescence immunoas
Coronavirus disease (COVID-19) booster doses decrease infection transmission and disease severity. This study aimed to assess the acceptance of COVID-19 vaccine booster doses in low, middle, and high-income countries of the East Mediterranean Region (EMR) and its determinants using the health belief model (HBM). In addition, we aimed to identify the causes of booster dose rejection and the main so
Shale gas extraction commonly known as fracking had support from the UK government with their ‘all out for shale’ policy. Despite this industry has struggled to establish itself mainly due to strong opposition from communities concerned about environmental and health impacts. Most research into the impacts of fracking is concerned with either environmental degradation or physical health impacts wh
5-Hydroxymethylfurfural (HMF) is a versatile bio-based platform chemical that can substitute fossil-derived intermediates in polymers, solvents, and fuels, thereby contributing to a fossil-free chemical industry. While first-generation feedstocks such as high-fructose corn syrup have been widely studied, their use raises concerns about competition with food supply. In contrast, second-generation r
The pulmonary route has emerged as a promising strategy for delivering protein therapeutics, particularly for patients suffering from respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary infections. This project investigated the effect of operating parameters of a laboratory spray dryer on the characteristics of powders composed of Bovine Serum Albumin
Dead wood is a key element in forest ecosystems and a wide range of organisms are dependent on this substrate for development and reproduction. Saproxylic beetles are important decomposers of dead wood and serve as food for many organisms. Due to the significant forestry-related decrease of dead wood in rural areas, many species of saproxylic beetles are considered threatened. Thus, other spaces h
Low-temperature vacuum spray drying (VSD) is a potential drying approach for probiotic and live biotherapeutic product (LBP) formulations. This thesis investigated VSD for Limosilactobacillus reuteri DSM 17938 as a model probiotic strain, with the aim of identifying a feasible lab-scale operating window and using data-driven analysis to support process understanding. Sucrose–maltodextrin formulati
In the central Himalayas, water dynamics are expected to change due to multiple factors like climate change, hydro power development and shifting land use practices. This thesis looks at possible changes in water dynamics in Marsyandi river basin, Nepal, as well as causes to those changes and how they are perceived locally. Grounded in critical physical geography, the study uses mixed methods an
This is a thesis project, analysing data from high-resolution imaging observations, specifically speckle imaging, as a follow up study of exoplanet host stars observed with K2, the second operational phase of the space telescope Kepler. The project was accomplished at NASA Ames research center under the guidance of Rachel A. Matson, during an internship in collaboration with the Swedish National S
Urban Sprawl is one of the challenges to urban development in many nations. Different aspects of the phenomenon have been researched with a view to providing solutions to myriad of ills attributed to it. For any meaningful intervention, however, assessment of development to ascertain sprawl is essential. Despite this, its quantification and monitoring in environment with paucity of data remains a
. Zia E, Melander O, Bjorkbacka H, Hedblad B, Engstrom G (Lund University, Malmo; Institute of Clinical Sciences, Lund University, Malmo; Skane University Hospital, Malmo; and Astra Zeneca R&D, Malmo, Sweden). Total and differential leucocyte counts in relation to incidence of stroke subtypes and mortality: a prospective cohort study. J Intern Med 2012; 272: 298304. Objectives. Elevated levels
