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Introduction Although various lipid and non-lipid analytes measured by nuclear magnetic resonance (NMR) spectroscopy have been associated with type 2 diabetes, a structured comparison of the ability of NMR-derived biomarkers and standard lipids to predict individual diabetes risk has not been undertaken in larger studies nor among individuals at high risk of diabetes. Research design and methods C
Aims: To assess feasibility and acceptability of exercise in clinically referred adolescents with major depression. Methods: Outpatients12 to 17 years with mild to moderate persistent depression participated in a supervised, pulse monitored, 14-week aerobic exercise but without control group. Primary outcome was adherence and secondary was clinician-rated Quick Inventory of Depressive Symptomatolo
OBJECTIVE: To evaluate psychometric properties of newly developed hand and wrist proprioception tests.DESIGN: Cross-sectional and test-retest comparisons.SUBJECTS/PATIENTS: Twenty-six individuals (mean age 40 years) with wrist disability (> 3 months) due to traumatic injury or general instability.METHODS: Pointing acuity (with eyes open and closed), active joint position sense (in extension, flexi
Background Type 1 diabetes begins with autoimmunity against pancreatic islet antigens, including insulin. The aim of the Primary Oral Insulin Trial (POInT) was to evaluate the efficacy and safety of daily high-dose oral insulin to prevent the development of islet autoantibodies and diabetes. Methods In this randomised, controlled, primary prevention trial, genetic screening in seven obstetric and
The last decade’s rise of the so-called “third frame” (or third generation) of Transformative Innovation Policies (TIP) has shifted focus of research and innovation investments from economic growth and competitiveness to also tackling societal challenges and generating broader environmental and societal impact. The evolution in rationale and aims for policy action also implies a need to adapt and
BACKGROUND: Swedish policy states that older adults should be able to age safely with continued independence and lead active lives. However, this plays out differently in different Swedish municipalities depending upon degree of demographic change, globalization, and urbanization. Internationally, older adults living in disadvantaged areas have worse physical and mental health, activity restrictio
BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
Extensive anti-government protests were held in Poland in October 2020 related to accumulated social tensions due to COVID-19 pandemic among others. We attempt a question of how understanding communication patterns among protesters could possibly support epidemiological harm reduction campaigns. To do so, we analysed tweets in Polish language with hashtags: #Strajkkobiet representing pro-choice mo
The current process of issuing industrial and mineral licenses is complex and time consuming. More specific, industry establishment generally makes environmental pollution. Such negative impact on environment is due to not using proper information and mechanisms for site selection and license issuance. This research suggests a new process/method based on WebGIS enable e-government to simplify the
Based on a discrete choice experiment with 336 consumers, this study investigated whether the consumer propensity to choose a simplified European Union (EU) vs. non-EU denomination of origin for beef, instead of a specific country-of-origin (COO) denomination, depends upon the amount and type of credence information provided to the individual. The likelihood of choosing the EU/non-EU denomination
Background: Work and other everyday activities are beneficial for well-being among people with mental illness, but poor circumstances can create detrimental effects, possibly aggravated by additional vulnerabilities linked with their mental illness. This study aimed to investigate how activity factors were related to well-being and functioning among three vulnerable groups using outpatient mental
The structural research programmes of the European Union dedicated to advance thesustainability sciences are increasingly permeated by thenotion of transdisciplinarity (TD). A growing body of literature residing at the intersection of research methodology and sustainability studies can guide researchers to adopt appropriate research approaches in their projects. However, how to implement the trans
One of the main reasons why we have failed to reach a sustainable development is due to the narrow focus on Gross Domestic Product (GDP) as the main development indicator. The sparsity of alternative indicators has created a misleading impression for policy makers, and society as a whole, about sustainability. In order to fulfil the new challenges of the Anthropocene we propose a widespread adopti
BACKGROUND: Heart failure (HF) is a common complication to atrial fibrillation (AF), leading to rehospitalization and death. Early identification of patients with AF at risk for HF might improve outcomes. We aimed to derive a score to predict 1-year risk of new-onset HF after an emergency department (ED) visit with AF. METHODS AND RESULTS: The RE-LY AF (Randomized Evaluation of Long-Term Anticoagu
Background: No definite consensus has been reached yet on the best treatment strategy for the large group of infants hospitalised with bronchiolitis or pneumonia. Minimal handling is often recommended, although not evaluated scientifically. There is a need to evaluate the management, as the infants often are critically affected, and the costs for society are high. The aim of this RCT was to evalua
The central nervous system coordinates movement through forces generated by motor units (MUs) in skeletal muscles. To analyze MUs function is essential in sports, rehabilitation medicine applications, and neuromuscular diagnostics. The MUs and their function are studied using electromyography. Typically, these methods study only a small muscle volume (1 mm3) or only a superficial (<1 cm) volume of
