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Urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine concentrations after frying of bacon, a pilot study

Cooking fumes contain compounds that may give rise to oxidative stress and mutations when inhaled. The aim of this study was to evaluate if cooking fumes from frying of bacon induce oxidative stress by measurement of urinary 8-oxo-7,8-dihydro-2 deoxyguanosine, a marker of oxidatively damaged DNA. Three non-smoking women fried bacon for 3 h. Urine samples were taken as early morning void at the sam

Hospital comparison of stroke care in Sweden : A register-based study

Background and purpose The objective of this study was to estimate the level of health outcomes and resource use at a hospital level during the first year after a stroke, and to identify any potential differences between hospitals after adjusting for patient characteristics (case mix). Method Data from several registries were linked on individual level: seven regional patient administrative system

Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation : A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

OBJECTIVE: Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS: A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition

Effect of delayed cord clamping of term babies on neurodevelopment at 12 months : A randomized controlled trial

Background: Delayed cord clamping (DCC) is associated with an improved iron status at 8 months, a reduction of anemia at 12 months, and an improved development at 4 years. Assessment of the development after DCC has not been performed earlier in a setting with a high prevalence of iron deficiency. Objective: The aim of this paper was to investigate the effects of DCC compared to early cord clampin

Analysis of complications after repair of hypospadias

We have reviewed 184 patients after repair of primary hypospadias. They were operated on and followed-up according to a standard protocol, and the senior author (HS) participated in all operations. The patients were reconstructed using a Byars two-stage procedure ( n = 102) or a Scuderi ( n = 29) or Mathieu ( n = 41) single-stage procedure. The rest ( n = 12) just had a removal of the chordee with

Platelet and leukocyte activation during aortoiliac angiography and angioplasty.

OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive gra

An Ael allele-specific nucleotide insertion at the blood group ABO locus and its detection using a sequence-specific polymerase chain reaction

Genomic DNA from each of four Acl individuals (genotypes AO1, AO1var, AO2) and one AclB individual was used as a template for amplifying exons 6 and 7 of the ABO genes, which were subsequently sequenced. In all the Ael alleles a single nucleotide insertion, compared to the A consensus sequence, was observed that would alter the amino acid sequence of the glycosyltransferase immediately after its p

Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)

Background: We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma. Methods: We performed an open-label one-arm, two-stage, phase II study of 25 mg of oral exemestane in 51 patients with advanced (FIGO stage III-IV) or relapsed endometrioid endometrial cancer. Patients were stratified into subsets of estro

A well-ordered surface oxide on Fe(110)

A well-ordered surface oxide grown on Fe(110) has been studied using scanning tunneling microscopy (STM), low energy electron diffraction, low energy electron microscopy, and core level photoelectron spectroscopy. The iron oxide film exhibits wide terraces and is formed after exposure to 100-1000 L at 1 x 10(-6) mbar O-2 and 400 degrees C. Two domains, mirror symmetric in the Fe(110)-lattice mirro

Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?

Background Trauma and its complications contribute to morbidity and mortality in the general population. Trauma victims are susceptible to acute respiratory distress syndrome (ARDS) and sepsis. Polymorphonuclear leucocytes (PMNs) are activated after trauma and there is substantial evidence of their involvement in the development of ARDS. Activated PMNs release heparin-binding protein (HBP), a gran

Decrease in high density lipoprotein cholesterol during prolonged storage. CELL Study Group

Different studies on the stability of high density lipoprotein cholesterol (HDL) in frozen serum or plasma have yielded conflicting results, namely increase, decrease, or no change at all during prolonged storage under freezing conditions. As part of a major trial on lipid-lowering strategies we statistically demonstrated a time-related decrease in HDL cholesterol during storage up to 46 months at

Protection against cold air and exercise-induced bronchoconstriction while on regular treatment with Oxis

This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim,

Disappointment and drop-out rate after being allocated to control group in a smoking cessation trial

BackgroundIf a patient agrees to take part in a randomised trial it is reasonable to presume that the patient would prefer to be allocated into the intervention. This study's aim was to investigate how patients react after they have been randomised into control group.MethodsNested study within two randomised trials. Telephone interviews with a structured questionnaire. The participants were invite

Is Innovation out of Control? An Explorative Study in Management Control Systems and the Business Model of Innovation

The aim of this explorative study is to examine the theoretical and empirical notions in the business model of innovation that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are highlighted and related to the diagnostic and interactive uses of part of the MCS, namely the performance measurement systems (PMS), and thThe aim of this explorative study is to examine the theoretical and empirical notions in the business model of innovation that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are highlighted and related to the diagnostic and interactive uses of part of the MCS, namely the performance measurement systems (PMS), and th

Interaction between cyclists and right turning motor vehicles at signalised intersections : Field observations and interviews with cyclists

The aim of the study presented in this report was to investigate what cues cyclists use to interpret the intention of motor vehicles (MVs) they interact with. This was done with help of on-site observations of cyclists’ interactions with motor vehicles (MV) at signalised intersections with different bicycle infrastructure facilities: A) no dedicated cycle facility, B) cycle lane and C) cycle path.The aim of the study presented in this report was to investigate what cues cyclists use to interpret the intention of motor vehicles (MVs) they interact with. This was done with help of on-site observations of cyclists’ interactions with motor vehicles (MV) at signalised intersections with different bicycle infrastructure facilities: A) no dedicated cycle facility, B) cycle lane and C) cycle path.