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Mitochondrial dysfunction is associated with pathogenic mitochondrial (mt)DNA mutations. The majority of mtDNA point mutations have a heteroplasmic status, which is defined as the coexistence of wild-type and mutated DNA within a cell or tissue. Previous findings demonstrated that certain mtDNA heteroplasmic mutations contribute to widely spread chronic diseases, including cancer, and alterations

The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage

Introduction: It is unclear if antibiotic prophylaxis reduces the risk of surgical site infection (SSI) in thyroid surgery. This study assessed risk factors for SSI and antibiotic prophylaxis in subgroups of patients. Method and design: A nested case–control study on patients registered in the Swedish National Register for Endocrine Surgery was performed. Patients with SSI were matched 1:1 by age

Coffee is epidemiologically linked to health benefits and risks. Coffee is thought to be a diuretic. However, it can still contribute to daily fluid intake. Vasopressin is the most important physiological regulator of body fluid balance and diuresis. This study aimed to map the effects of coffee intake on vasopressin concentration. In the population-based cross-sectional Malmö Offspring Study (n =

BACKGROUND: The changes of cancer incidence upon immigration can be used as an estimator of environmental influence on cancer risk. We studied site-specific liver and biliary cancers in first-generation immigrants to Sweden with an aim to search for aetiological clues and to find evidence for indigenous incidence rates. MATERIAL AND METHODS: We used the nation-wide Swedish Family-Cancer Database t

PURPOSEAPR-246 (PRIMA-1MET) is a novel drug that restores transcriptional activity of unfolded wild-type or mutant p53. The main aims of this first-in-human trial were to determine maximum-tolerated dose (MTD), safety, dose-limiting toxicities (DLTs), and pharmacokinetics (PK) of APR-246. PATIENTS AND METHODSAPR-246 was administered as a 2-hour intravenous infusion once per day for 4 consecutive d

Due to the consistently high proportion of surgical site infections (SSI) after vascular surgery, a change of prophylactic antibiotic therapy from cloxacillin/cefotaxime to trimethoprim/sulfamethoxazole (TMP-SMX) was conducted in 2016. The study included consecutive patients undergoing lower extremity revascularization due to acute or chronic lower extremity arterial disease. The antibiotic regime

Intracerebral transplantation of porcine embryonic dopamine-producing neurons has been suggested as a method to treat patients with Parkinson's disease. Even though the brain is an immunologically privileged site, neuronal xenografts are usually rejected within a few weeks. T cells are important for this process, but the exact cellular events leading to rejection are poorly characterized. Brain ce

Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children

Nitrogenase is the only enzyme that can cleave the strong triple bond inN2. The active site contains a complicated MoFe7S9C cluster. It is believed that itneeds to accept four protons and electrons, forming the E4 state, before it can bind N2.However, there is no consensus on the atomic structure of the E4 state. Experimentalstudies indicate that it should contain two hydride ions bridging two pai

Background Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations before a pregnancy can be visualized with ultrasonography. Methods We conducted a multicenter, noninferiority, randomized, controlled trial involving women requesting medication abortion at up to 42

COSM51 International Relations in East and South-East Asia: Issues and Cases Course Schedule Autumn Semester 2024 2 October – 31 October Date Time Class Location 7/11 13-16 Introduction Library 12/11 13-15 Grand Strategy in East Asia: The US Library 12/11 15-17 Guest Lecture: Library 14/11 13-16 Grand Strategy in East Asia: China Library 19/11 13-16 Japan: A New Great Power? Library 21/11 13-16 So

https://www.ace.lu.se/sites/ace.lu.se/files/2025-09/COSM53%20Schedule%202025.docx - 2026-04-25

COSM53 Schedule 2025 COSM51 International Relations in East and South-East Asia: Issues and Cases Course Schedule Autumn Semester 2024 2 October – 31 October Date Time Class Location 7/11 13-16 Introduction Library 12/11 13-15 Grand Strategy in East Asia: The US Library 12/11 15-17 Guest Lecture: Library 14/11 13-16 Grand Strategy in East Asia: China Library 19/11 13-16 Japan: A New Great Power? L

https://www.ace.lu.se/sites/ace.lu.se/files/2025-09/COSM53%20Schedule%202025.pdf - 2026-04-25

COSM53: Grand Strategy, Geopolitics and the Fate of East Asia Course Schedule Autumn Semester 2025 3 November – 2 December Date Time Class Location 7/11 13-16 Introduction Library 12/11 13-15 Grand Strategy in East Asia: The US Library 12/11 15-17 Guest Lecture: Library 14/11 13-16 Grand Strategy in East Asia: China Library 19/11 13-16 Japan: A New Great Power? Library 21/11 13-16 South Korea: A M

https://www.ace.lu.se/sites/ace.lu.se/files/2025-10/COSM53%20Schedule%202025%202.docx - 2026-04-25

LL_SMMV28_eng_VT21_rev210216 Reading list for Destination Developmen and Marketing (SMMV28), 15 credits. The reading list was approved by the Board of the Department of Service Management and Service Studies 2020-01-29, revised 2021-02-16. The reading list is valid from 2021-03-22. Avraham, Eli, & Ketter, Eran. (2013). Marketing destinations with prolonged negative images: Towards a theoretical mo

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2021-02/LL_SMMV28_eng_VT21_rev210216.pdf - 2026-04-25

https://www.fil.lu.se/fileadmin/_migrated/content_uploads/Practical_Info_POI-POIQ_Workshop_Lund_10_May_2013.pdf - 2026-04-23

Microsoft Word - Kombinerad CV Publ 2013 IB ongoing CURRICULUM VITAE OF INGAR BRINCK (last updated approx. 2015) Division of Theoretical Philosophy Department of Philosophy and Cognitive Science Lund University Lund, Sweden fax: 0046 (0)46 222 44 24 ingar.brinck@fil.lu.se Associate member of Institut Jean Nicod, Paris (elected 2006) Institut Jean Nicod belongs to the CNRS), The Institut Jean Nicod

https://www.fil.lu.se/media/documents/persons/IngarBrinck/CV_Brinck_2015.pdf - 2026-04-23

General Regulations and Information Academic Year 23-24 Page 1 of 8 General Regulations and Information - Validity: 2023/2024 - Approved by: Assistant Dean Kristofer Modig - Date of approval: 10 March 2023 In addition to the General Regulations and Information, the programme syllabus for the respective programme at the Faculty of Engineering (LTH) also applies. 1 General information 1.1 LTH, progr

https://www.student.lth.se/fileadmin/lth/student/Utbildningsplaner_2023_och_fram/General_Regulations_and_Information_Academic_Year_23-24_ny.pdf - 2026-04-23