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Närståendes tillfredsställelse med vården på en intensivvårdsavdelning
Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics
Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de
Countercurrent Distribution of Lymphocytes from Human Peripheral Blood in an Aqueous Two-Phase System : I. Separation into Subsets of Lymphocytes Bearing Distinctive Markers’
Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o
Longitudinal Associations between Survival in Alzheimer's Disease and Cholinesterase Inhibitor Use, Progression, and Community-Based Services.
Background/Aims: Factors including rate of disease progression, different aspects of cholinesterase inhibitor (ChEI) treatment, and use of community-based services might affect the longitudinal outcome of Alzheimer’s disease (AD). Whether these factors alter life expectancy in AD is unclear. We therefore examined the association between long-term ChEI therapy and survival. Methods: The present stu
"Den passiva majoriteten" – en nyckel till varaktig förändring
Could you be more specific? Examples as crucial rhetorical tools in discourse on 'others'.
In everyday conversations, we frequently give an example. Yet this is seldom accompanied by any reflection on what is going on when we do so. This report tries to contribute such a reflection. It shows how examples may be marked and used in a particular discourse: oral discourse on others. The empirical material is a transcribed focus group interview with a group of Swedish students, engaged in di
Schema mven06 v1
Centrum för miljö- och klimatforskning, CEC, Miljövenetskaplig Utbildning, Sölvegatan 37, 223 62 Lund http://www.miljovetenskap.lu.se/ MVEN06 - Miljöövervakning, 15p VT16 (Obs: alla tider med kvart!) Kurstid: - Kurschef: Adam Kristensson, tel:046-2227645, email: adam.kristensson@nuclear.lu.se Johan Hollander, tel:046-2223473, email: Johan.Hollander@biol.lu.se Lärare: Namn Email AKR Adam Kristensso
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven06_v1.pdf - 2026-06-23
Från förening till företag - Sportslig kontra ekonomisk framgång
Syftet med uppsatsen är att undersöka vad framgång är i dagens skandinaviska elitfotbollsklubbar och vilka strategier som är användbara för att uppnå denna. Uppsatsen ämnar således belysa och klargöra de viktigaste aspekterna i en lyckad strategi inom en modern skandinavisk fotbollsklubb. Med denna kunskap har vi för avsikt att återge en bild över hur en elitfotbollsklubb strategiskt bör organiser
Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructures
Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amino acid sequence of more than 75 amino acids (aa 552-635) for antibody binding. We
Comparison of Surface Properties of Human IgA, IgE, IgG and IgM Antibodies with Identical and Different Specificities
In this paper, the authors report the use of liquid-liquid partition chromatography (LLPC) in an aqueous polyethylene glycol (PEG)/dextran two-phase system to compare the surface properties (partition properties) of human antibodies and fragments thereof. The surface properties of all the monoclonal antibodies of different classes and subclasses investigated were within the same broad range as tha
Purification of streptococcal protein G expressed by Escherichia coli by high performance liquid affinity chromatography using immobilized immunoglobulin G and albumin
A one-step HPLC method was developed for the purification of protein G, a cell wall molecule from group C and G streptococci with immunoglobulin G- and albumin-binding properties. Lysed Escherichia coli bacteria infected with lambda-phages containing the protein G gene from group G streptococci were used as a starting material for the preparations. The lysate was applied to a column with immobiliz
Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis
To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is assoc
Antibody-dependent allostery of the M1 protein
Den förrädiska antikroppen Streptokocker är en lömsk bakterie som har många olika sätt att ta sig runt vårt immunförsvar. Den kan låtsas vara en del av vår kropp genom att klä sig själv i en proteinkapsel som är väldigt likt ett mänskligt protein, bryta ned våra celler med hjälp av utsöndrade gifter och använda vårt immunförsvar mot oss genom att binda antikroppar till sig själv. En virulensfaktoThe Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands
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Arvet från von Sydow En betraktelse i anledning av ett halvsekeljubileum Av]an-Öjvind Swahn 1939 motionerade författaren, folkdikts utgivaren och socialdemokratiske politi kern Fredrik Ström, tillsammans med ett dussin andra riksdagsmän från olika par tier i Första kammaren, om inrättandet av en personlig professur i nordisk och jäm förande folkminnesforskning i Uppsala för Carl Wilhelm von Sy
MVES04 Schema 2023 v3, AMW
Centrum för miljö- och klimatforskning, CEC, Miljövetenskaplig Utbildning, Sölvegatan 37, 223 62 Lund http://www.miljovetenskap.lu.se/ Schema MVES04 (tidigare MVEN06) - Miljöövervakning, 15p VT23 ( Obs: alla tider med akademisk kvart! ) Kurstid: 22 mars - 4 juni Kurschef: Adam Kristensson, tel:046-2227645, email: adam.kristensson@nuclear.lu.se Yann Clough, tel: 046-2226831, email: yann.clough@cec.
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2023-02/MVES04_Schema%202023_v3,%20AMW.pdf - 2026-06-22
Redox control of exocytosis - Regulatory role of NADPH, thioredoxin, and glutaredoxin
Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel
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Der Artikel geht der Rolle des Irrtums in Per Olov Enquists DokumentarromanLegionärerna (1968, Die Ausgelieferten) nach, der die Auslieferungvon baltischen Militärflüchtlingen an die Sowjetunion durch den schwedischenStaat im Jahr 1946 behandelt. In einem ersten Schritt wird aufgezeigt,inwiefern die Kategorie des Irrtums zentrale thematische und narrativeFunktionen in Enquists Romanarchitektur erf
Prevalence and comorbidity of psychiatric disorders among treatment-seeking elite athletes and high-performance coaches
Objectives Few studies have evaluated the prevalence of psychiatric disorders among treatment-seeking elite athletes (EA) or high-performance coaches (HPC) in psychiatric outpatient settings. Methods Descriptive overview of EA and HPC with psychiatric disorders at two publicly funded psychiatric outpatient treatment clinics in Stockholm and Malmö, Sweden. Co-occurring psychiatric disorders were il
Methane and carbon dioxide fluxes over a lake : Comparison between eddy covariance, floating chambers and boundary layer method
Freshwaters bring a notable contribution to the global carbon budget by emitting both carbon dioxide (CO2) and methane (CH4) to the atmosphere. Global estimates of freshwater emissions traditionally use a wind-speed-based gas transfer velocity, kCC (introduced by Cole and Caraco, 1998), for calculating diffusive flux with the boundary layer method (BLM). We compared CH4 and CO2 fluxes from BLM wit
