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Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae

Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotics currently in clinical use have been rendered ineffective due to the rapid spread of antimicrobial resistance among gonococci. The developmental pipe

Experiments and Large Eddy Simulation of Supersonic Combustion in the Small-Scale Flight Experiment

Supersonic combustion is a critical area of research for advancing high-speed flight technologies, particularly for the development of scramjet engines for hypersonic vehicles. This study employs Finite Rate Chemistry (FRC) Large Eddy Simulation (LES) together with different experimental techniques to study the supersonic flow and thermochemical processes in the Small Scale Flight Experiment (SSFE

IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G.

Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and its host. Here we describe the identification, purification and characterization of a novel extracellular cysteine proteinase produced by S.pyogenes. This enzyme, designated IdeS for Immunoglobulin G-

Molecular mapping of epitopes for interaction of HIV-1 as well as natural ligands with the chemokine receptors, CCR5 and CXCR4.

OBJECTIVE: Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta. DESIGN: Receptor hybrids between CCR5 and CXCR4 were constructed. METHODS: Using single-overlap and extension PCR, increasing portions of CCR5 were replaced with correspond

GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65

GAD65 autoantibodies (GAD65Ab) are highly prevalent in type 1 diabetes, but their functional role in the pathogenesis of the disease and their relationship to T-cell reactivity to GAD65 is still unclear. We tested the hypothesis that GAD65Ab modulate presentation of GAD65 to T-cells. T-cell hybridoma T33.1, which recognizes the GAD65 274-286 epitope in the context of HLA-DRB1*0401, was incubated w

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The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity me

Production and Functional Characterization of Der p 1-Specific Human Recombinant IgE

Ny forskning bidrar till ökad förståelse av allergiska reaktioner Allergi har ökat dramatiskt under de senaste åren. Det är därför högst väsentligt att få ökad kunskap om hur beståndsdelarna i immunförsvaret hos allergiska personer samspelar. Förekomsten av allergi har kommit att öka dramatiskt under de senaste åren och har blivit ett betydande problem för folkhälsan. Allergi drabbar en så stor dThe prevalence of allergic disease is continuing to increase worldwide, and it has even become a major concern in public health. Allergic reactions are developed to otherwise harmless substances and may be both life-threatening as well as discomforting for patients in their daily life. Therefore, a more detailed knowledge about how antibodies interact with allergens and effector cells in allergic

SWEAH Verksamhetsberättelse 2021 Fastställd

Nationella forskarskolan om åldrande och hälsa Fastställd av SWEAH:s styrelse 2022-04-20 Verksamhetsberättelse 2021 Nationella forskarskolan om åldrande och hälsa www.sweah.lu.se http://www.sweah.lu.se/ Nationella forskarskolan om åldrande och hälsa Verksamhetsberättelse 2021 2 Innehållsförteckning sida Omslagsfoto: Marylou Fortier, Unsplash Sammanfattning 3 Styrelse 4 Partners 5 Forskarskolans le

https://www.sweah.lu.se/sites/sweah.lu.se/files/2022-06/SWEAH%20verksamhetsber%C3%A4ttelse%202021%20fastst%C3%A4lld.pdf - 2026-05-09

Medicinska Fakulteten - Några Historiska Nedslag Wistrand Et.al (2019)

Microsoft Word - 2019 Jubileumsbok 135x200 mm 1 Medicinska fakulteten --- några historiska nedslag 2 3 Medicinska fakulteten – några historiska nedslag 4 Omslagsbilder: Framsida: Gamla kirurgiska kliniken, byggd 1867-68 efter rit- ningar av Helgo Zettervall. Här bedrevs kirurgisk verksamhet fram till 1968. Fotograf okänd. Baksida: Stampen till medicinska fakultetens äldsta bevarade sigill, sent 16

https://www.medicinhistoria.lu.se/sites/medicinhistoria.lu.se/files/2025-02/Medicinska%20fakulteten%20-%20N%C3%A5gra%20historiska%20nedslag%20Wistrand%20et.al%20(2019).pdf - 2026-05-09

Effektivisering av arbete med klimatdeklarationer inom byggsektorn

On January 1, 2022, the first requirement regarding climate declarations was introduced. This mandate specified that all new buildings must include climate declarations during the construction phase, encompassing modules A1-A5. In 2025, limit values are also planned to be added for the existing modules included in the 2022 climate declarations. These required values will be implemented as a signif

Static and Dynamic Analyses considering Contact Mechanics

Static and Dynamic Analyses considering Contact Mechanics Master’s Dissertation Structural Mechanics Report TV SM -5204 JU LIU S Å K ERBLO M och FRED RIK RA D LERT K O M FO R T H O S G Å N G - O C H C Y K ELB R O A R JULIUS ÅKERBLOM och FREDRIK RADLERT KOMFORT HOS GÅNG- OCH CYKELBROAR 5204HO.indd 15204HO.indd 1 2016-01-06 17:41:292016-01-06 17:41:29 DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5204.pdf - 2026-05-07

On the Application of Surface Wave Surveys for Seismic Site Response Evaluation

In sites where earthquakes occur, the use of surface wave methods represents a convenient and effective procedure for soil characterization. In particular, Multichannel Analysis of Surface Wave (MASW) has become a popular tool in many seismic micro-zoning projects. In common practice the active MASW method is implemented using a sledgehammer source and a linear receiver spread. This method is lim

Unraveling EU’s Strategic Autonomy - Analysing the EU’s Path to Independence amidst Global Interconnections

This thesis investigates the EU’s strategic autonomy which refers to the EU’s strive for increased independence without having to rely on other countries in important policy areas. EU strategic autonomy was introduced in 2013 and has become a higher priority due to recent geopolitical changes. The research question is how the EU balances strategic autonomy with their commitments to multilateralism