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A randomized controlled trial comparing intensive non-surgical treatment with bariatric surgery in adolescents aged 13–16 years (AMOS2) : Rationale, study design, and patient recruitment

Background: Previous non-randomized studies show similar outcomes in adolescents and adults after bariatric surgery. We describe the study protocol, recruitment, and selected baseline data of patients in a randomized multi-center study, the Adolescent Morbid Obesity Surgery 2 (AMOS2). Methods: Three clinics in Sweden collaborated in designing the study and recruitment of patients from August 1, 20

Wear behaviour of PVD (Ti,Si)N-(Ti,Al)N coated cemented carbide in down milling pearlitic compacted graphite iron

Compacted graphite iron (CGI) is an intermediate material between conventional grey cast iron and the stronger, more wear resistant ductile iron, making it a suitable material choice for different automotive applications. The improved material properties of CGI as to conventional grey cast iron makes it more difficult to machine, and finding a suitable tool material with low wear rates is a challe

H2 formation from the E2–E4 states of nitrogenase

Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological lifeforms. The active site is a MoFe7S9C cluster (the FeMo cluster) that binds eight electrons and protons during one catalytic cycle, giving rise to eight intermediate states E0–E7. It is experimentally known that N2 binds to the E4 state and that H2 is a compulsory biproduct of t

A Role for Wnt Signaling in the Reversal of Metabolic Disturbances after Gastric Bypass in Obese Mice

Gastric bypass surgery has benefi cial effects on obesity-induced metabolic disturbances, but the underlying mechanisms remain unclear. As Wnt genes are both positively and negatively correlated with obesity-induced adipose tissue infl ammation and insulin resistance, our main aim is to reveal a potential role for Wnt signaling in the reversal of these metabolic consequences after gastric bypass s

Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels

Gastric bypass surgery results in remission of type 2 diabetes in the majority of patients. The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been implicated in the observed remission. Most knowledge so far has been generated in obese subjects. To isolate the surgical effects of gastric bypass on metabolism and hormone responses from

Immunogenetics of Parkinson's disease: Translational studies from rodents to humans

Parkinson's disease (PD) is a complex neurodegenerative disease, characterized by a progressive lossof dopaminergic neurons (DN) in the substantia nigra (SN) that innervate the striatum (ST) and pathologicalaccumulation of alpha-synuclein (αsyn) protein in aggregates called Lewy bodies (LB) and Lewy neurites(LN). As a complex disease, PD presents a genetically heterogeneous origin. Mutations in si

Aktuell forskning i Arbets- och organisationspsykologi vid Institutionen för Psykologi, Lunds Universitet

I denna text skisseras forskningen vid avdelningen för Arbets- och organisationspsykologi vid Institutionen för Psykologi, Lunds Universitet. Avdelningen består idag av två doktorander, ett 10-tal forskare/lärare samt några mer löst tillknutna kollegor. Samarbete sker med flera interdisciplinära forskningsmiljöer på Lunds Universitet. Exempelvis är avdelningen idag representerad i två fakultetsöveI denna text skisseras forskningen vid avdelningen för Arbets- och organisationspsykologi vid Institutionen för Psykologi, Lunds Universitet. Avdelningen består idag av två doktorander, ett 10-tal forskare/lärare samt några mer löst tillknutna kollegor. Samarbete sker med flera interdisciplinära forskningsmiljöer på Lunds Universitet. Exempelvis är avdelningen idag representerad i två fakultetsöve

Variations in tropospheric submicron particle size distributions across the European continent 2008-2009

Cluster analysis of particle number size distributions from background sites across Europe is presented. This generated a total of nine clusters of particle size distributions which could be further combined into two main groups, namely: a south-to-north category (four clusters) and a west-to-east category (five clusters). The first group was identified as most frequently being detected inside and

Gates and Gods. Cults in the City Gates of Iron Age Palestine. An Investigation of the Archaeological and Biblical Sources.

The present study deals with the question of cult locales in city gate contexts in Iron Age Palestine. Both archaeological and biblical sources are analysed in order to determine the presence of gate cult locales and indicate some directions of interpretation. A general framework for the archaeological identification of cult (as proposed by Colin Renfrew and others) is discussed and applied within

Cutinase-peptide fusions in thermoseparating aqueous two-phase systems - Prediction of partitioning and enhanced tag efficiency by detergent addition

It is of increasing importance to develop efficient purification methods for recombinant proteins where the number of steps can be minimised. The aim has been to establish a method for predicting the partitioning of the wild-type target protein in an aqueous two-phase system, and with this as basis, develop fusion tags and optimise the phase system for enhanced partitioning of the target protein.

Energy limitations for spring migration and breeding: the case of brent geese Branta bernicla tracked by satellite telemetry to Svalbard and Greenland

Brent geese were tracked by satellite telemetry from spring staging areas in Denmark to Arctic breeding areas in Svalbard and Greenland in 1997 and 2001. From estimated departure masses and carcass analysis we used flight mechnical theory to estimate maximum flight ranges of both sexes, and remaining stores of fat and protein upon arrival in females. Model predictions suggested that all birds but

Reduced Irregularity of Ventricular Response During Atrial Fibrillation and Long-term Outcome in Patients With Heart Failure.

Reduced heart rate variability (HRV) is associated with poor outcome in patients with heart failure (HF). However, the data on predictive value of RR variability during atrial fibrillation (AF) are limited. Therefore, the aim of this study was to evaluate the association between ventricular response characteristics and long-term clinical outcome in the population of ambulatory patients with mild-t

Thermodynamics for complex formation between palladium(II) and oxalate

Complex formation between [Pd(H2O)(4)](2+) and oxalate (ox = C2O42-) has been studied spectrophotometrically in aqueous solution at variable temperature, ionic strength and pH. Thermodynamic parameters at 298.2 K and 1.00 mol dm(-3) HCIO4 ionic medium for the complex formation [Pd(H2O)(4)](2+) + H(2)ox (sic) Pd(H2O)(2)(ox)] + 2H(3)O(+) with equilibrium constant K-1H (in mol dm(-3)) are logio K-1,K

Organic synthesis in water - Investigations of Lewis acid catalysis and chiral hydrophobic auxiliaries in aqueous Michael additions

Asymmetrisk katalys har under de senaste decennierna utvecklats kraftigt. År 2001 delade Knowles, Noyori och Sharpless Nobelpriset i kemi för sina banbrytande bidrag inom just detta område. Utmaningen idag är att utveckla nya metoder inom asymmetrisk katalys som även tar hänsyn till vår växande miljöpåfrestning. Nästan alla av dagens kirala katalysatorer är utvecklade för syntes i organiska lösnin

Likt ett brustet halleluja : trons och tvivlets tematik i Christine Falkenlands prosa

This dissertation is a study of the Christian thematics in the novels of Christine Falkenland. It has two basic aims. First, to demonstrate how Christine Falkenland writes herself into, and becomes a distinct voice in, a Christian literary tradition, while simultaneously breaking with this tradition by staging and portraying modern people’s questioning of the Christian worldview. Second, to uncove

Vi ska göra det lätt för kunden att välja rätt för en hållbar utveckling” En analys av två drivmedelsbolags kommunikation av ansvar gällande klimat- och miljöfrågor

"We shall make it easy for the customer to choose the right for a sustainable development". An analysis of the two fuel companies' communication of responsibilities regarding climate and envi-ronmental issues. This master thesis examines how two fuel companies rhetorically communicates its view of responsibility for environmental and climate issues on their websites. In order to prov