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Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site

Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of on

Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress

Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many diseases including Duchenne muscular dystrophy (DMD). Oxidative stress, heat shock proteins, endoplasmic reticulum (ER) stress and its response, i.e. unfolded protein response (UPR), play key roles in proteostasis but their involvement in t

Reconstructing institutional stability and change Conceptualizing the social ontology of institutional stability and change in Historical Institutionalism

Questions about institutional stability and change are critically important for any understanding of political institutions. The field of Historical institutionalism in political science has described, studied and theorized institutions for decades. One of the most recurring concepts utilized in the explanation of institutional stability is path dependence, describing theoretical and empirical mec

Enzymatic autoantibody glycan hydrolysis alleviates autoimmunity against type VII collagen

Autoantibody-mediated diseases comprise a heterogeneous group of disorders in which the pathogenic potential of autoantibodies has been clearly demonstrated. In general, their treatment relies on the long-term use of systemic corticosteroids and other immunosuppressants that are associated with considerable adverse reactions. EndoS, an endoglycosidase derived from Streptococcus pyogenes, specifica

Methane fluxes from a small boreal lake measured with the eddy covariance method

Fluxes of methane, CH4, were measured with the eddy covariance (EC) method at a small boreal lake in Sweden. The mean CH4 flux during the growing season of 2013 was 20.1 nmol m−2 s−1 and the median flux was 16 nmol m−2 s−1 (corresponding to 1.7 mmol m−2 d−1 and 1.4 mmol m−2 d−1). Monthly mean values of CH4 flux measured with the EC method were compared with fluxes measured with floating chambers (

Handkirurgi och dess specifika omvayrdnad

Handkirurgi och dess specifika omvårdnad U PP D R A G SU TB IL D N IN G Institutionen för hälsovetenskaper erbjuder utbildningar som genomförs av lärare vid Lunds universitet och i många fall i samarbete med arbetslivet - en garanti för både ämnesmässig bredd och aktualitet, ett vetenskapligt djup och en modern pedagogik. Institutionens uppdragsverksamhet sker i samarbete med Lund University Commi

https://www.medicin.lu.se/sites/medicin.lu.se/files/handkirurgi_och_dess_specifika_omvayrdnad.pdf - 2026-05-27

Expression, activity, and subcellular localization of testicular hormone-sensitive lipase during postnatal development in the guinea pig

The present work reports on testicular hormone-sensitive lipase (HSL), the biological significance of which has been documented in male fertility. The HSL protein levels and enzymatic activity were measured, respectively, by densitometry of immunoreactive bands in Western blots, performed with antibodies against recombinant rat HSL, and by spectrophotometry in seminiferous tubules (STf) and inters

Development of asymmetrical flow field-flow fractionation-multi angle laser light scattering analysis for molecular mass characterization of cationic potato amylopectin

The goal of this study is to investigate the applicability of asymmetrical flow field-flow fractionation (AsFlFFF)–multi angle laser light scattering (MALLS), and to develop a method for analysis of cationic potato amylopectin (CPAP) having ultrahigh molecular mass (UHMr). Use of the aqueous carrier having low salt content (3 mM NaN3) resulted in a distortion in AsFlFFF fractograms of CPAP with a

Development and validation of a machine learning-based model to predict isolated post-challenge hyperglycemia in middle-aged and elder adults : Analysis from a multicentric study

Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a

Human igg increases virulence of streptococcus pyogenes through complement evasion

Streptococcus pyogenes is an exclusively human pathogen that can provoke mild skin and throat infections but can also cause fatal septicemia. This gram-positive bacterium has developed several strategies to evade the human immune system, enabling S. pyogenes to survive in the host. These strategies include recruiting several human plasma proteins, such as the complement inhibitor, C4b-binding prot

Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing

Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and new immunotherapeutic strategies to treat this emerging pathogen are needed. Comp

Yngre svartgods : datering, funktion och produktion : en materialstudie av det yngre svartgodset från kv. Apotekaren 4, Lund

This essay should be regarded as an artifact study and as a foundation for continued research. As very little has been written about younger blackware, the focal point of this study is on key problems such as dating, function and production. The material of the study is from the excavation of Kv. Apotekaren 4, carried out 1979-1980. The stratigraphy of the site was well dated with dendrochronology