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Evaluation of methods for aerosolising polystyrene latex nanoparticles and assessment of their toxicity

Aerosolised Polystyrene Latex (PSL) nanoparticles are, due to their well-defined size, spherical shape, and inert surface, useful in many experimental applications, including studies of particle deposition in the human lung. Aerosolising nanoparticles entails added challenges, and nanoparticles can potentially be more hazardous than otherwise equivalent microparticles. The objective of this work w

Establishing a pipeline for production of recombinant antibodies utilizing Extensible Mammalian Modular Assembly (EMMA) kit

Production of Recombinant Antibodies Using Modular Cloning Antibodies are a part of the immune system tasked in recognizing and binding foreign substances, antigens, and recruiting other parts of the immune system to neutralize them. Antibodies are Y-shaped proteins consisting of two heavy and two light chains. Both light and heavy chains contribute to the variable and constant regions of the ant

Characterization of individuals fulfilling clinical criteria for limbic-predominant age-related TDP43 encephalopathy (LATE) in a tertiary memory clinic

BACKGROUND: Limbic-predominant age-related TDP-43 encephalopathy (LATE) clinically mimics and often co-occurs with Alzheimer's disease (AD). Expert consensus criteria have been proposed for the LATE clinical diagnosis, integrating clinical and radiological features, and AD biomarkers. Here, we applied the newly proposed criteria in a tertiary memory clinic population. METHOD: We included participa

Impact beyond academia - a guide to help preparing for impact evaluations

Impact beyond academia A GUIDE TO HELP PREPARING FOR IMPACT EVALUATIONS Part of the project report on the monitoring of the Lund University SRAs TEXT Pia Romare, avdelning Samverkan, LU, 2018 pia.romare@fsi.lu.se PHOTOS Cover: Kennet Ruona Page 22: Mikael Kanski, Ida Thelander Page 23: Kennet Ruona 3IMPACT BEYOND ACADEMIA Table of contents INTRODUCTION .............................................

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/impact_beyond_academia_-_a_guide_to_help_preparing_for_impact_evaluations.pdf - 2026-05-30

Age- and sex-dependent differences in white matter pathology in the chronic phase of diffuse traumatic brain injury in the mouse

Traumatic brain injury (TBI) is commonly associated with white matter injury, leading to persistent symptoms and long-term disability. While advanced age is linked to worse outcome post-TBI, the influence of sex remains highly controversial. The present study aimed to identify age- and sex-dependent differences in white matter pathology during the chronic phase of TBI using the central (midline) f

Dynamic capabilities in disaster management exercises

This paper introduces the concept of 'dynamic capability' (DC) in relation to disaster management - in particular to disaster management exercises (DME). Firstly this paper discusses changes and challenges in DME and the concept of dynamic capabilities as one potential approach dealing with the existing challenges in DME. Thereafter it outlines basic contents of developing DC in DME. The paper con

The role of parent and offspring sex on risk for externalizing psychopathology in offspring with parental alcohol use disorder : a national Swedish study

Purpose: The substantial literature showing that offspring of parents with alcohol use disorder (AUD) is at increased risk for externalizing psychopathology rarely examines the differential effects of parental and offspring sex. This literature also has other important limitations, such as modest sample sizes and use of unrepresentative samples. Using a large, nationwide Swedish sample, we aim to

Laser wakefield accelerated electron beams and betatron radiation from multijet gas targets

Laser Plasma Wakefield Accelerated (LWFA) electron beams and efficiency of betatron X-ray sources is studied using laser micromachined supersonic gas jet nozzle arrays. Separate sections of the target are used for the injection, acceleration and enhancement of electron oscillation. In this report, we present the results of LWFA and X-ray generation using dynamic gas density grid built by shock-wav

HPV vaccination and the risk of invasive cervical cancer

BACKGROUND The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking. METHODS We used nationwide Swedish demographic and health registers to follow an open population of 1

A virtual trial framework for quantifying the detectability of masses in breast tomosynthesis projection data

Purpose: Digital breast tomosynthesis (DBT) is a promising breast cancer screening tool that has already begun making inroads into clinical practice. However, there is ongoing debate over how to quantitatively evaluate and optimize these systems, because different definitions of image quality can lead to different optimal design strategies. Powerful and accurate tools are desired to extend our und

Development and Evaluation of Methods in Source Apportionment of the Carbonaceous Aerosol

Atmosfäriska partiklar (aerosoler) finns överallt i jordens atmosfär. Masskoncentrationen av dessa varierar kraftigt beroende på i vilken miljö man mäter. I stadsluft kan man uppmäta tiotals mikrogram per kubikmeter medan man i arktiska områden uppmäter nanogram per kubikmeter. Den kolhaltiga aerosolen utgör en betydande del av atmosfärsaerosolens massa och är känd för att påverka människors och dCarbonaceous aerosols are known to affect human health negatively and to affect the climate of Earth. As specific types of aerosols originate from specific sources, it is important to know the amount of aerosols emitted from each source. Aerosol source apportionment is an important tool in mitigating air pollution and improving air quality. The subject of this thesis was the evaluation and develop

Drug abuse-associated mortality across the lifespan : a population-based longitudinal cohort and co-relative analysis

Purpose: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. Method: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Re

Enskild egendom, giftorättsgods eller lite av varje? - En studie av gällande rätt i fråga om surrogat av blandad karaktär

Denna uppsats behandlar problematiken rörande surrogat av blandad karaktär, det vill säga sådan ersättningsegendom som finansieras delvis genom makes giftorättsgods, delvis genom dennes enskilda egendom. Syftet är att utreda huruvida delningsprincipen, där surrogategendomen delas upp proportionellt i de två egendomsslagen, eller huvudsaklighetsprincipen, vilken innebär att hela surrogatet klassifiThis thesis explores the challenge concerning mixed substitute property, meaning property acquired partly through the marital property of a spouse, partly through their separate property. The purpose is to investigate whether such property should be classified as both separate and marital, split proportionally, or as either separate or marital in entirety when division of property between spouses

How to treat software in the intellectual property framework

Mjukvaruindustrin är idag en av de viktigaste industrierna i världen, och flerparten av de apparater vi använder innehåller mjukvara. Eftersom mjukvara har både en litterär del och en uppfinningsrik del har det varit oklart hur mjukvara ska skyddas. Den kan skyddas av patent, som täcker idén bakom programmet, och upphovsrätt, som täcker uttrycket av idén. Ett program endast skyddat av upphovsrätt

Dynamically predicted shelf-life label in minced meat product: A consumer-driven design and analysis

Dynamically predicted shelf-life label (DPSL) has been discussed to be one of the solutions to curb meat waste. Therefore, the research about the DPSL label and the perceptible information obtained by minced meat consumers is conducted. The research purpose is to identify the critical factors to design a DPSL label for minced meat consumers, and to design and assess the label with the consumers. T

Tidiga förhör i praktiken

I svensk straffprocessrätt har omedelbarhetsprincipen haft stor betydelse sedan rättegångsbalken infördes år 1948. Den innebär att domstolen bara ska döma över det som har framkommit under huvudförhandlingen. Domstolen har inte innan huvudförhandlingen läst polisens utredning, utan parter och vittnen ska komma till domstolen och lämna sin berättelse direkt inför rätten. Den 1 januari 2022 infördeIn Swedish criminal procedure law, the principle of immediateness has been of great significance since the code of judicial procedure came into effect in 1948. This implies that the court should only judge and present verdicts based on what has appeared during the main hearing. Hence, the court will not have read the pre-trial investigation before the main hearing. Instead, the implicated parties

Breast cancer. Quality Assurance and Prognosis.

Popular Abstract in Swedish Sammanfattning på svenska Den svenska nationella cancerstategin från 2009 understryker patientperspektivet och fokus ligger på själva patientprocessen. Modern bröstcancerbehandling omfattar en mer individualiserad behandling med bröstbevarande kirurgi, diagnostik av portvaktskörteln, ett ökat användande av medicinsk terapi med cellgift, antihormon samt antikroppar i såAbstract Background. The Swedish national cancer strategy programme published in 2009 emphasises the patient perspective and focuses on the patient process. Over the years the different modalities in breast cancer treatment are changing position, making accurate diagnosis and quality assurance in breast pathology even more important than before. Aims. The aim of paper I was to examine overall su