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Purpose: High-performing imaging and predictive markers are warranted to minimize surgical overtreatment of the axilla in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Here we have investigated whether axillary ultrasound (AUS) could identify axillary lymph node (ALN) metastasis (ALNM) pre-NACT and post-NACT for BC. The association of tumor, AUS features and mammographic d

Background: Nodal assessment in gallbladder cancer remains challenging, particularly in incidental gallbladder cancer. This understages the number of patients with node-positive disease, resulting in prognostic inaccuracy and insufficient adjuvant treatment. This study aimed to identify risk factors for positive nodes in gallbladder cancer and to compare prognostic discrimination of available noda

Den svenska familjerättsliga regleringen har sedan länge präglats av strävan att söka tillgodose barnets intresse i relation till föräldrarna. Ett tydligt uttryck för denna strävan finner man i föräldrabalkens 6 kap. 2 a § där det stadgas att barnets bästa ska vara avgörande för alla beslut om vårdnad, boende och umgänge. En ytterligare strävan i den familjerättsliga regleringen har varit att sökaSwedish family law has long been governed by the aspiration to accommodate the interests of the child, rather than that of the parents. A distinct expression of this aspiration can be found in a provision of the Swedish Children and Parents code, 6 chapter § 2 a. In this provision it is stated that the best interests of the child shall be the determining factor in all decisions regarding custody,

BackgroundThe relationship between sleeping habits and aortic stiffness remains inconclusive and is not fully explored in the European general population.MethodsWe examined cross-sectionally 8659 participants from the Swedish population-based cohort Swedish CArdioPulmonary bioImage Study (SCAPIS), mean age 57.5 years, 52.1% women. A self-administered questionnaire on sleeping habits (duration, qua

Background: Alzheimer's disease (AD) biomarkers, such as cerebrospinal fluid (CSF) amyloid-β (1–42; Aβ42), can provide high diagnostic accuracy. Several immunoassays are available for Aβ42 quantitation, but standardisation across assays remains an issue. We compared the Elecsys® β-Amyloid (1–42) CSF assay with three assays and two liquid chromatography tandem mass spectrometry (LC-MS/MS) methods.

Background: Trauma to the pancreas is rare but associated with significant morbidity. Currently available management guidelines are based on low-quality evidence and data on long-term outcomes is lacking. This study aimed to evaluate clinical characteristics and patient-reported long-term outcomes for pancreatic injury. Methods: A retrospective cohort study evaluating treatment for pancreatic inju

Diffusion MRI is a non-invasive imaging technique used to study the microstructural properties of biological tissues by observing the self-diffusion of water molecules. Traditional diffusion MRI methods, based on the pulsed gradient spin-echo sequence, employ magnetic field gradients to encode information about translational motion. However, this approach combines various aspects of diffusion, suc

To better predict the timely variation of algal blooms and other vital factors for safer drinking water production, a new AI scanning–focusing process was investigated for improving the simulation and prediction of algae counts. With a feedforward neural network (FNN) as a base, nerve cell numbers in the hidden layer and the permutation and combination of factors, etc., were fully scanned to selec

Fragmentation of habitat, for example by intensive agricultural practices, can be detrimental to local biodiversity. However, it often remains unclear whether such biodiversity declines are caused by loss of habitat area or increased fragmentation, and how habitat quality factors into it. In our study system, vegetated vineyards are typically small, and isolated from one another, potentially limit

By harnessing the powers of polycrystalline materials an unprecedented, technologically-driven age has taken formover the last 100 years. The polycrystal is today, arguably, the most central building block for electronics, renewableenergy, transportation and medical equipment industries. This material class is the reason for the emergence of thepowerful microprocessors, semiconductors, memory chip

Objective: To examine the associations between the American Heart Association scores (“Life's Essential 8” [LE8] and “Life's Simple 7” [LS7]) and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC). Patients and Methods: We included a population-based sample, aged 50 to 64 years, recruited between 2013 and 2

Programming is a cognitively demanding exercise. In particular, today’s software development requires a collective effort of programmers and the orchestration of a complex programming infrastructure. As disruptive technologies emerge, e.g., AI and quantum computing, the programming practice is undergoing a change, facing an uncertain future that we may not be able to accurately predict but can env

Background: Several studies have shown associations between cadmium (Cd) exposure and an increased risk of fractures. However, the size of the risk is still unclear and proper adjustment for smoking is a challenge. The aim of this study was to quantify the association between dietary cadmium measured in blood and fracture risk in the general Swedish population through a large population-based case

Pollinators play a central role in shaping the astounding diversity of angiosperm flowers. Flowers are complex, multidimensional, genetically and functionally integrated phenotypes, rendering it a challenge to quantify and interpret observed trait variation. Even variation in simpler trait measurements is a challenge to interpret, because of the multitude of selective agents and evolutionary proce

BACKGROUND AND AIMS: Endoscopy and the use of faecal calprotectin [faecal CP] are among the least-favoured methods for assessing disease activity by inflammatory bowel disease [IBD] patients; the handling/processing of faecal samples is also impractical. Therefore, we sought to develop a novel neo-epitope serum calprotectin enzyme-linked immunosorbent assay [ELISA], CPa9-HNE, with the aim of quant

Aim: The aim was to identify the primary drivers of compositional change in breeding bird assemblages over a 40-year period. Location: Britain. Time period: From 1970 to 2010. Major taxa studied: Birds. Methods: Using morphological trait measurements and a dataset of presence–absence data for British breeding birds surveyed in 10 km × 10 km hectads during two time periods, we calculated temporal t

Substantial variability exists in what pathologists consider as pT4a in colorectal cancer when tumor cells are within 1 mm of the free peritoneal surface. This study aimed to determine if the measured sub-millimeter distance between tumor cells and the free peritoneal surface would offer an objective means of stratifying patients according to the risk of developing peritoneal metastases. Histologi

Background Systemic lupus erythematosus (SLE) is a complex disease characterized by autoimmunity toward apoptotic cells, excessive amounts of circulating immune complexes, and complement activation. A decreased platelet size has been observed in SLE and their nonhemostatic functions may play an active role in the disease. The main objective of this study was to find clues that could explain their

Concussion is a frequent injury in many sports and is also common in para athletes. However, there is a paucity of concussion research related to para sport, and prior International Concussion in Sport (CIS) consensus papers have not substantively addressed this population. To remedy this and to improve concussion care provided to para athletes, the concussion in para sport (CIPS) multidisciplinar

Determining the architecture of multi-planetary systems is one of the cornerstones of understanding planet formation and evolution. Resonant systems are especially important as the fragility of their orbital configuration ensures that no significant scattering or collisional event has taken place since the earliest formation phase when the parent protoplanetary disc was still present. In this cont