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Removal of Powerline Noise in Geophysical Datasets With a Scientific Machine-Learning Based Approach

The most common noise in geophysical data is probably interference from powerlines. This noise manifests itself as a sinusoidal signal oscillating at the fundamental 50 or 60 Hz frequency of the power grid and as harmonic components oscillating at integer multiples. Many different mitigation strategies, tailored for the specific geophysical method, have been developed to target powerline noise. On

Tolerance of metal halide perovskites to mechanical treatment enables the fabrication of patterned luminescence nano- and microstructures

Metal halide perovskites have shown a great performance in a broad range of optoelectronic devices. The variety of preparation methods makes perovskites especially attractive, yet preparation of complex nanostructures based on these materials remains challenging. Here we present a template assisted method allowing to achieve any pre-designed arrangement of methylammonium lead triiodide (MAPbI3) po

Community-onset urosepsis : incidence and risk factors for 30-day mortality–a retrospective cohort study

Background: Urosepsis is a life-threatening condition that needs to be addressed without delay. Two critical issues in its management are: (1) Appropriate empirical antibiotic therapy, considering the patients general condition, comorbidity, and the pathogen expected; and (2) Timing of imaging to identify obstruction requiring decompression. Objectives: To identify risk factors associated with 30-

The Gaia-ESO Survey : Impact of extra mixing on C and N abundances of giant stars

Context. The Gaia-ESO Public Spectroscopic Survey using FLAMES at the VLT has obtained high-resolution UVES spectra for a large number of giant stars, allowing a determination of the abundances of the key chemical elements carbon and nitrogen at their surface. The surface abundances of these chemical species are known to change in stars during their evolution on the red giant branch (RGB) after th

Acute inflammatory biomarker responses to diffuse traumatic brain injury in the rat monitored by a novel microdialysis technique

Neuroinflammation is a major contributor to the progressive brain injury process induced by traumatic brain injury (TBI), and may play an important role in the pathophysiology of axonal injury. The immediate neuroinflammatory cascade cannot be characterized in the human setting. Therefore, we used the midline fluid percussion injury model of diffuse TBI in rats and a novel microdialysis (MD) metho

Astrometry and exoplanets in the Gaia era : A Bayesian approach to detection and parameter recovery

The Gaia mission is expected to make a significant contribution to the knowledge of exoplanet systems, both in terms of their number and of their physical properties. We develop Bayesian methods and detection criteria for orbital fitting, and revise the detectability of exoplanets in light of the in-flight properties of Gaia. Limiting ourselves to one-planet systems as a first step of the developm

Hormonal contraception increases the risk of psychotropic drug use in adolescent girls but not in adults : A pharmacoepidemiological study on 800 000 Swedish women

The burden of depression and anxiety disorders is greater in women, and female sex hormones have been shown to affect mood. Psychological side effects of hormonal contraception (HC) are also a common complaint in the clinic, but few previous studies have investigated this subject. We therefore wanted to investigate whether use of HC was associated with adverse psychological health outcomes, and wh

Essays on Matching

This thesis makes a contribution to matching theory and mechanism design. It consists of four self-contained papers focusing on kidney exchange, object allocation and partnership formation. The first paper, Pairwise Kidney Exchange over the Blood Group Barrier, investigates how the use of immunosuppressive drugs can be implemented within kidney exchange programs. Thanks to advances in medicine, im

Diagnostic accuracy of troponin T measured ≥6h after symptom onset for ruling out myocardial infarction

Objectives: Guidelines recommend a single high-sensitivity cardiac troponin T (hs-cTnT) ≤14 ng/L measured ≥6 h after chest pain onset combined with a GRACE score <140 and the patient being pain-free for ruling out myocardial infarction (MI). There is however little data on the performance of this strategy. We therefore aimed to evaluate the diagnostic accuracy of a hs-cTnT ≤14 ng/L measured ≥6 h a

Evaluating the safety benefit of retrofitting motorways section with barriers meeting a new EU standard : Comparison of observational before–after methodologies

The road safety barriers are today designed and installed in compliance with the European standards for Road Restraint Systems (EN 1317), which lays down common requirements for the testing and certification in all EU countries. The introduction of the European Union (EU) regulation for safety barriers, which is based on performance, has encouraged European road agencies to perform an upgrade of t

The effect of the recombination rate between adaptive loci on the capacity of a population to expand its range

Previous theoretical work on range expansions over heterogeneous environments showed that there is a critical environmental gradient where range expansion stops. For populations with freely recombining loci underlying the trait under selection (hereafter, “adaptive loci”), the critical gradient in one-dimensional habitats depends on the fitness cost of dispersal and the strength of selection relat

What is a Challenging Clot? : A DELPHI Consensus Statement from the CLOTS 7.0 Summit

Background: Predicting a challenging clot when performing mechanical thrombectomy in acute stroke can be difficult. One reason for this difficulty is a lack of agreement on how to precisely define these clots. We explored the opinions of stroke thrombectomy and clot research experts regarding challenging clots, defined as difficult to recanalize clots by endovascular approaches, and clot/patient f

Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders

Objective People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown. Methods We collected longitudinal diagnostic information (mean=36 mon

In situ assembly of bioresorbable organic bioelectronics in the brain

Bioelectronics can potentially complement classical therapies in nonchronic treatments, such as immunotherapy and cancer. In addition to functionality, minimally invasive implantation methods and bioresorbable materials are central to nonchronic treatments. The latter avoids the need for surgical removal after disease relief. Self-organizing substrate-free organic electrodes meet these criteria an

Doses to carotid arteries after modern radiation therapy for hodgkin lymphoma : Is stroke still a late effect of treatment?

Purpose Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along w

Acute and Long-Term Changes in Blood-Borne Biomarkers in Response to Dynamic Standing in Nonambulant Children With Cerebral Palsy

PURPOSE: To investigate acute and long-term changes in hormonal and inflammatory biomarkers in nonambulant children with cerebral palsy in response to dynamic standing exercise.METHODS: Fourteen children with severe cerebral palsy were recruited. Anthropometrics and body composition measures were obtained. Physical activity levels before the study were assessed using hip-worn accelerometry. All ch

Methods to simplify diet and food life cycle inventories : Accuracy versus data-collection resources

The number of Life Cycle Assessment (LCA) studies on foods and diets steadily increases. However, due to lack of data on food products as well as time and resource constraints, many of these studies ignore part of the system (e.g. cooking and waste in the household), which may lead to underestimating impacts greatly. This LCA study compared diets using six methods with different system boundaries;

A multi-scale in silico mouse model for diet-induced insulin resistance

Insulin resistance causes compensatory insulin production, which in humans can eventually progress to β-cell failure and type 2 diabetes (T2D). This disease progression involves multi-scale processes, ranging from intracellular signaling to organ and whole-body level regulations, on timescales from minutes to years. T2D progression is commonly studied using overfed and genetically modified rodents

An extended FGM model with transported PDF for LES of spray combustion

An enhanced flamelet generated manifold (FGM) model for large eddy simulation (LES) of turbulent spray combustion is presented. In the enhanced FGM model, a transported probability density function (TPDF) description of the FGM variables is employed. The TPDF is represented using the Eulerian stochastic fields (ESF) approach, and the method is applied to LES of spray combustion under conditions re