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The integrated nature of the Sustainable Development Goals (SDGs) presents a challenge to implementing the 2030 Agenda. Analytical methods to support decision-makers are often developed without explicitly incorporating decision-makers’ views and experience. Here, we investigate whether existing methods are fit-for-purpose in supporting decision-makers at national and subnational levels. We identif
Climate change and human activities influence the development of ecosystems, with human demand of ecosystem services altering both land use and land cover. Fossil pollen records provide time series of vegetation characteristics, and the aim of this study was to create spatially continuous reconstructions of land cover through the Holocene in southern Sweden. The Landscape Reconstruction Algorithm
The building blocks of Titan and Enceladus are believed to have formed in a late-stage circumplanetary disk (CPD) around Saturn. Evaluating the evolution of the abundances of volatile species in this disk as a function of the migration, growth, and evaporation of icy grains is then of primary importance to assess the origin of the material that eventually formed these two moons. Here we use a simp
Glucagon is secreted from the pancreatic alpha cells and plays an important role in the maintenance of glucose homeostasis, by interacting with insulin. The plasma glucose levels determine whether glucagon secretion or insulin secretion is activated or inhibited. Despite its relevance, some aspects of glucagon secretion and kinetics remain unclear. To gain insight into this, we aimed to develop a
Background: Current clinical decision rules to exclude deep vein thrombosis (DVT) are underused partly because of their complexity. A simplified rule that can be easily applied would be more appealing to use in clinical practice. Methods: We used individual patient data from prospective diagnostic studies of patients suspected of DVT to develop a new clinical decision rule. The primary outcome was
Currently, static cold storage (SCS) of hearts from donations after brainstem death remains the standard clinically. However, machine perfusion (MP) is considered an approach for donor organ management to extend the donor pool and/or increase the utilization rate. This review summarizes and critically assesses the available clinical data on MP in heart transplantation. We searched Medline (PubMed)
crataegi Germar, 1824. The first specimen was found in the city of Malmö in the southernmost province of Sweden in the beginning of October 2020, where one individual had taken shelter from a heavy morning rain on a house wall, together with several other beetle species. The species was subsequently sought after during late autumn and winter by sifting litter beneath putative host plants, but it c
In the early morning, large groups of up to hundreds or even thousands of roosting birds, sometimes comprising the entire roost population, often take off together in sudden mass departures. These departures commonly occur in low-light conditions and structurally complex habitats where access to visual cues is likely to be restricted. Roosting birds are often highly vocal, leading us to hypothesis
Background: Cardiac arrest (CA) represents the third leading cause of death worldwide. Among patients resuscitated and admitted to hospital, death and severe neurological sequelae are frequent but difficult to predict. Blood biomarkers offer clinicians the potential to improve prognostication. Previous studies suggest that circulating non-coding RNAs constitute a reservoir of novel biomarkers. The
A radial flow cell (RFC, inlet tube radius 0.95 mm and gaps of 1–4.2 mm) was used to investigate the removal of two thin (80–230 µm thick) model soil layers from glass and 304 stainless steel substrates by the flow of water at 20 °C. Under the flow conditions employed (Reynolds numbers 200–1400), inertial effects give rise to recirculation zones and regions of high shear stress on the bottom, soil
In this paper a baseline of contemporary access to justice research is established. The baseline clearly illustrates key features of the research field suggesting that while the field of research has become more multifaceted in the course of the last two or three decades, it is nevertheless very much dominated by law scholarship and structural analysis of legal service provision. Departing from th
Stars near the Sun oscillate both horizontally and vertically. In a previous paper by Binney it was assumed that the coupling between these motions can be modelled by determining the horizontal motion without reference to the vertical motion, and recovering the coupling between the motions by assuming that the vertical action is adiabatically conserved as the star oscillates horizontally. Here, we
Efficient intracellular nucleic acid delivery into mammalian cells remains a long-standing challenge owing to poor cell permeability and uptake of naked nucleic acids across the cell membrane and limited cargo stability. Conventional delivery methods have several drawbacks, such as cytotoxicity, limited cell-type applicability, low efficiency, hindrances that limit the potential of oligonucleotide
In the formulation of an active enzyme enclosed in a matrix for controlled delivery, it is a challenge to achieve a high protein load and to ensure high activity of the protein. For the first time to our knowledge, we report the use of a highly swollen lipid sponge (L3) phase for encapsulation of the large active enzyme, β-galactosidase (β-gal, 238 kDa). This enzyme has large relevance for applica
The shear plate dowel joint (SPDJ) is a novel connection design for heavy timber structures. The connection uses a single large diameter dowel and glued-on steel plates to transfer loads between members. Consequently, the design of the dowel is of great influence for the global performance of the connection. This paper presents an experimental and numerical investigation of the influence of the ge
