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Peptide binding to HLA molecules is a critical step in induction and regulation of T-cell mediated immune responses. Because of combinatorial complexity of immune responses, systematic studies require combination of computational methods and experimentation. Most of available computational predictions are based on discriminating binders from non-binders based on use of suitable prediction threshol

The microarray technology has revolutionized biological research in the last decade. By monitoring the expression of many genes simultaneously, microarrays can elucidate gene function, as well as scan entire genomes for candidate genes encoding complex traits. However, because of high costs of sequencing and design, microarrays have largely been restricted to a few model species. Cross-species mic

A non-associated plasticity theory for granular materials has been developed in Part 1 based on the concept of a characteristic stress state of vanishing incremental dilation. The model is fully three-dimensional and is defined by six material parameters: two for elastic stiffness, one for plastic stiffness, two for the shapes of yield and plastic potential surfaces and one for the dilation at fai

Homogeneous Charge Compression Ignition (HCCI) holds great promises for good fuel economy and low emissions of NOdx and soot. The concept of HCCI is premixed combustion of a highly diluted mixture. The dilution limits the combustion temperature and thus prevents extensive NOdx production. Load is controlled by altering the quality of the charge, rather than the quantity. No throttling together wit

Popular Abstract in Swedish Avhandlingens titel är ju "Redovisning av goodwill". Därför kan det vara lämpligt att fråga sig vad de orden betyder i detta sammanhang. Goodwill har här inte den vanliga betydelsen av det goda anseende som exempelvis ett företag åtnjuter. Det är istället en benämning på skillnaden mellan värdet på hela företaget och summan av värdena på de enskilda tillgångarnaEvery conceivable manner of accounting, in the same country, at the same time! This is how-with no great exaggeration-the accounting of goodwill in Sweden in the late 1980s might well be described. Many companies still followed the Accounting Act, amortizing their goodwill over no more than ten years. Some, however, referred to the rules in the United States, extending the amortization peri

Lysine-specific chemical crosslinking in combination with mass spectrometry is emerging as a tool for the structural characterization of protein complexes and protein-protein interactions. After tryptic digestion of crosslinked proteins there are thousands of peptides amenable to MSMS, of which only very few are crosslinked peptides of interest. Here we describe how the advantage offered by off-li

The development of inhibitory antibodies to factor VIII is a serious complication of haemophilia. Two haemostatic agents with different bypassing mechanisms have been used in the treatment of patients with inhibitors: activated prothrombin complex concentrate (aPCC) and recombinant factor VIIa (rFVIIa). The objective was to compare cost and outcome of aPCC and rFVIIa in the treatment of joint blee

Bluespec SystemVerilog (BSV) is a declarative hardware description language based on a synthesizable subset of System Verilog. Developing with BSV means so far to use scripts for existing editors, which enable highlighting and seldom support of the BSV compiler. The absence of a real IDE for BSV makes writing programs an inconvenient task. This project tries to improve this by providing an BSV Ec

Buildings are getting taller due to increased urbanisation and densification of cities. More advanced construction methods and the desire to construct impressive buildings is also supporting the trend. Due to their inherent slenderness resulting in low eigenfrequencies, these buildings are susceptible to wind-induced vibrations which can be highly disturbing for occupants. Already barely perceivab

Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in β cell gene regulation and diabetes, the function of β cell lncRNAs remains largely unknown. In this stud

Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression

Graphical user interface (GUI) development is generally complicated, time-consuming, and requires programming knowledge. In the context of the internet of things, this work focuses on producing an efficient development approach that also supports non-experts. We introduce a novel "inverted" development approach that does not require program code to be written - a step towards supporting end-user d

BACKGROUND: Glutamic acid decarboxylase antibodies (GADA) and tyrosine phosphatase antibodies (islet antigen-2 antibodies; IA-2A) are used in clinical practise to identify type 1 diabetes. METHODS: GADA and IA-2A were measured with RSR-ELISA kits in samples from 76 newly diagnosed type 1 diabetic children and 120 healthy controls. The aim was to evaluate performance of RSR-ELISA kits for GADA and

We present a digital solution for the front-end electronics of high resolution calorimeters at future colliders. It is based on analogue signal compression, high speed A/D converters, a fully programmable pipeline and a digital signal processing (DSP) chain with local intelligence and system supervision. This digital solution is aimed at providing maximal front-end processing power by performing w

Single-photon emission computed tomography (SPECT) is important for imaging radioactivity distributions in vivo. Quantitative SPECT is limited due to attenuation and scatter contribution. Approximations such as constant attenuation and mono-exponential scatter functions will not be valid for non-homogeneous regions. A correction method is described where non-uniform density-maps are used in the at

A level crossing predictor or alarm system with prediction horizon k is said to be optimal if it, at time t detects that an upcrossing will occur at time t + k, with a certain high probability and simultaneously gives a minimum number of false alarms. For a Gaussian stationary process, the optimal level crossing predictor can be explicitly specified in terms of the predicted value of the process i

Negative-pressure wound therapy (NPWT) has been used for the treatment of deep sternal wound infection (DSWI) with promising results. However, questions have been raised regarding the potential risk of right ventricle (RV) rupture during treatment. In the present study, we evaluate our clinical experience of NPWT focusing on RV rupture and major bleeding complications and its potentially negative