Sökresultat

Popular Abstract in Swedish Denna avhandling gäller glibenklamid som är vårt vanligaste läkemedel för oralt bruk i behandlingen av diabetes mellitus, typ 2 (åldersdiabetes). Glibenklamids upptag, fördelning, omsättning och utsöndring har studerats i detalj hos friska människor samt hos patienter med diabetes. Därtill har läkemedlets och dess metaboliters kinetik relaterats till farmako-dynamiska eGlibenclamide (Gb) is the most commonly employed sulphonylurea worldwide for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). There has been uncertainty concerning its pharmacokinetics (PK) and pharmacodynamics (PD). Numerous long-lasting hypoglycemic reactions, which have sometimes been fatal, have been reported and have been difficult to reconsile with an allegedly short elimina

Due to its gentle and high resolving power, chromatography is the work horse within protein separation. Still it is an expensive method due to low productivity, diluted product streams, large waste streams and expensive support material. This limits its potential use to areas of high price products. Therefore there is a clear interest to make the technology cheaper to use both for the existing pha

Fungi are a group of organisms with the ability to produce different types of enzymes in order to get access to nutrients. Among the enzymes, oxidoreductases have the ability to degrade lignocellulosic material via an oxidative mechanism, facilitating the uptake of cellulosic material, which will be metabolized using other enzymes to provide the required nutrients to the fungi. Ecologically, oxido

1. The mechanisms by which cooling inhibits insulin secretion were investigated by capacitance measurements of exocytosis in single mouse pancreatic B-cells maintained in short-term tissue culture. 2. A reduction of the bath temperature from 34 to 24 degrees C produced a gradual inhibition of exocytosis. Inhibition of exocytosis was use dependent rather than time dependent. The steady-state inhibi

The Swedish composer John Fernström (1897-1961) wrote over 200 pieces in the genres of symphonic music, chamber music and vocal music for mixed choirs, male choirs and solo vocals accompanied by piano. He lived most of his life in the province of Scania, first working in Helsingborg from 1916­ 1939 as a violinist in Nordvästra Skånes Orkester- förening [the Northwest Scanian Orchestra], whereafter

Rapid changes in bird community composition at multiple temporal and spatial scales in response to recent climate change 313 Rapid changes in bird community composition at multiple temporal and spatial scales in response to recent climate change Å ke Lindstr ö m , Martin Green , G ö ran Paulson , Henrik G. Smith and Vincent Devictor Å . Lindstr ö m (ake.lindstrom@biol.lu.se), M. Green and H. G. Sm

https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-1462013lindstromcti.pdf - 2026-05-11

Limträbågar med lång spännvidd har ofta ett väldigt högt och slankt tvärsnitt. Detta medför risk för vippningsinstabilitet. En jämnsymmetrisk belastning av bågen ställer oftast inte till något problem, men då bågen belastas osymmetriskt uppkommer stora böjmoment som ökar risken för instabilitet markant. Raka balkar som belastas med punktlaster eller utbredda laster får ett tryck i balkens överkanGlulam arches with long span often have a very high and slender cross-section. This may cause lateral torsional buckling of the arch. A symmetrical loading doesn’t usually become a problem, but if the arch is loaded asymmetrical there will be large bending moments that increases the risk of instability significantly. Straight beams that are subjected to point loads or distributed loading will be s

Att människan påverkar klimatet och att utsläpp av växthusgaser värmer planeten är ingen nyhet. Byggsektorn stod 2015 för 18 % av Sveriges totala utsläpp av växthusgaser och 2018 lanserade Bygg- och anläggningssektorn en färdplan för att nå en klimatneutral värdekedja tills år 2045. Tidigare studier har pekat på att majoriteten av klimatpåverkan ifrån flerbostadshus kommer från driftskedet, men seThe emissions of greenhouse gases caused by the construction sector represented 2015 18 % of Sweden’s total greenhouse emissions and the sector had by 2018 published a plan on how to reach a climate neutral value chain by 2045. Studies have shown that the construction phase has become a larger part of the climate impact from new-built multi-family residential buildings than before, in, in relation

Despite awareness of the negative consequences of car use, leisure trips are still often made by car. A better understanding of the potential for a transition to more sustainable transport behaviour requires more knowledge about the differences in car use between individuals and leisure trip purposes. As a basis for this, individuals were clustered into six car-oriented and five non-car-oriented l

This interview-based study seeks to gain insight into the varying motivations behind car usage across different societal groups, alongside their attitudes towards travel behavior and transportation options. Its overarching goal is to delve deeper into the factors and constraints that influences individuals’ car use and mode choice. The research methodology involves collecting one-month travel data

Zircons from anatectic melts of the country rocks of three Proterozoic mafic-ultramafic intrusions from the Sveconorwegian Province in SW Sweden were microanalyzed for U-Th-Pb and rare earth elements. Melting and interaction of the wall rocks with the intrusions gave rise to new magmas that crystallized zircon as new grains and overgrowths on xenocrysts. The ages of the intrusions can be determine

By the end of the eighteenth century, Leiden was a very unhealthy city where life was characterised by disease and untimely death – in particular young children – mainly because of high population density and unhygienic conditions. Morbidity and a high mortality rate gave city life a specific dynamic: many children grew up without one or both parents present, while many elderly men and women had t