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Solvation of protein surface charges plays an important role for the protonation states of titratable surface groups and is routinely incorporated in low dielectric protein models using surface accessible areas. For many-body protein simulations, however, such dielectric boundary methods are rarely tractable and a greater level of simplification is desirable. In this work, we scrutinize how charge

In this study, we performed a population viability analysis on 3 domestic horse breeds (Equus caballus) of Danish origin, namely, the Frederiksborg, the Knabstrupper, and the Jutland breeds. Because of their small population sizes, these breeds are considered endangered. The Vortex software simulation package was used for the population viability analysis. First, we investigated the future viabili

In radioimmunotherapy of tumors, uptake of the monoclonal antibody (MAb) used is often too low in relation to its uptake in normal tissues. The purpose of these studies was to improve experimental tumor radioimmunotargeting with (a) extracorporeal immunoadsorption (ECIA), where excess of radiolabeled MAbs circulating in blood is removed, (b) or by preload with unlabeled MAb prior to injection of r

Pay-What-You-Want (PWYW) pricing schemes are becoming increasingly popular in a wide range of industries. We develop a model incorporating self-image into the buyer's utility function and introduce heterogeneity in consumption utility and image-sensitivity, which generates different purchase decisions and optimal prices across individuals. When a good is sold at a fixed price higher than a thresho

Three different biological extremes of irradiation of living organisms, both human and animal, have been investigated and are presented in this thesis. Central to the thesis is the concept of bystander effects of ionizing radiation, i.e. biological responses in a cell that are not caused by that cell receiving a direct hit by ionizing radiation but by the fact that a neighbouring cell has been hit

Heat transfer in gas turbine related applications is investigated by steady state liquid crystal thermography (LCT) in this thesis. The work presented includes outlet guide vane heat transfer and gas turbine internal cooling.The heat transfer on the outlet guide vane (OGV) surface and its endwall region is investigated experimentally in a linear cascade test facility. The inlet flow angle is varie

Material and methods: In all, 237 consecutive patients with a perforated peptic ulcer admitted from 1974-1992 and 125 consecutive patients with an oesophageal perforation admitted from 1970-2006 to Lund University hospital were studied retrospectively. Prognostic factors were evaluated using the Cox proportional hazards model. All cases of gastro-duodenal ulcer perforations diagnosed in Sweden fr

Flow cytometry provides accurate relative cellular quantitation (percent abundance) of cells from diverse samples, but technical limitations of most flow cytometers preclude accurate absolute quantitation. Several quantitation standards are now commercially available which, when added to samples, permit absolute quantitation of CD4+ T cells. However, these reagents are limited by their cost, techn

Over the past five years, moisture damages in external walls of wood frame structure and rendering on insulation as a cladding has been a widely debated subject which has received a lot of attention. In the light of this, the interest in an alternative construction method where rendering is applied on boards instead of insulation has increased. In this method, carrier boards are mounted on battens

Industrial robots are fast and accurate when working with known objects at precise locations in well-structured manufacturing environments, as done in the classical automation setting. In one sense, limited use of sensors leaves robots blind and numb, unaware of what is happening in their surroundings. Whereas equipping a system with sensors has the potential to add new functionality and increase

In a previous study, we found that juvenile northern wheatears (Oenanthe oenanthe) exposed to a magnetic displacement to the west of their natural migration route increased their body mass. The total intensity and inclination used for the western displacement may also have been interpreted as northern compared to the experimental site (stronger total field intensity and steeper inclination angle).

In the present work, platinum and palladium nanoparticles (PtNPs and PdNPs) were decorated on the surface of multi-walled carbon nanotubes (MWCNTs) by a simple thermal decomposition method. The prepared nanohybrids, PtNPs-MWCNTs and PdNPs-MWCNTs, were cast on the surface of spectrographic graphite electrodes and then Phanerochaete chrysosporium cellobiose dehydrogenase (PcCDH) was adsorbed on the

Thermal neutron beams are an indispensable tool in physics research. The spatial and the temporal resolution attainable in experiments are dependent on the flux and collimation of the neutron beam which remain relatively poor, even for modern neutron sources. These difficulties may be mitigated by the use of optics for focusing and imaging. Refractive and diffractive optical elements, e.g. compoun

Popular Abstract in Swedish Cellerna i kroppen är uppbyggda av fyra olika byggstenar: DNA, proteiner, fetter samt kolhydrater. Kolhydrater förknippas framförallt med energi och det pågår en intensiv debatt om kolhydraternas vara eller icke vara i vår kost. Kolhydraterna har dock också en helt annan funktion, en som är obestridligt oumbärlig för alla levande organismer. I denna roll förekommer de bGalectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now suggests important roles of galectins in both cancer and inflammation. The aim of this project is to get a c

This study investigated the feasibility of targeting the free, unbound forms of prostate-specific antigen (fPSA) for in vivo imaging of prostate adenocarcinomas (PCa), as PSA is produced and secreted at abundance during every clinical stage and grade of PCa, including castration-resistant disease. We injected (125)I-labeled monoclonal antibody PSA30 (specific for an epitope uniquely accessible on

To better utilize existing wireless systems, they can be combined together to interact and thereby provide better balanced capacity. They can further profit from this by getting their ongoing connection moved from the current system to another. The main issues are to make this move without losing the ongoing connection and to make it seamless, i.e., without the user noticing it. This action of mov

In this thesis, methods for efficiently determining stresses in laminated glass structures are developed and tested. The laminated glass structures comprise both bolted and adhesive joints. A recently developed finite element is suggested to be suitable for the modeling of laminated glass structures. The element is implemented and tested. It is proven by means of a simple test example that the ele