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BACKGROUND: Clinicians normally use subjective rating scales to estimate the impairment of patients with Parkinson's disease (PD). More objective and quantitative methods of assessment would greatly aid our understanding of the disease. One promising approach is to measure reaction time: the large amount of data recorded in a short period provides precise, reproducible evaluation of the underlying

The ultrafiltration (UF) with diafiltration is the state-of-the-art process in the bulk pharmaceutical industry to separate solutions containing high and low molecular weight solutes. By applying UF with diafiltration, a feed stream can be separated into a concentrate with a high concentration of high molecular weight solutes and a permeate, which is nearly 100% free of high molecular weight solut

We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction

Recently, mass spectrometry (MS) has emerged as an important tool for high-throughput screening (HTS) providing a direct and label-free detection method, complementing traditional fluorescent and colorimetric methodologies. Among the various MS techniques used for HTS, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) provides many of the characteristics required for high-th

The production of Z bosons with one or two isolated high-energy photons is studied using pp collisions at s=8 TeV. The analyses use a data sample with an integrated luminosity of 20.3 fb-1 collected by the ATLAS detector during the 2012 LHC data taking. The Zγ and Zγγ production cross sections are measured with leptonic (e+e-, μ+μ-, νν) decays of the Z boson, in extended fiducial regions defined i

The ability to draw other agents’ attention to objects and events is an important skill on the critical path to effective human-robot collaboration. People use the act of pointing to draw other people’s attention to objects and events for a wide range of purposes. While there is significant work that aims to understand people’s pointing behavior, there is little work analyzing how people interpret

There is a long critical literature about popular television's role in the public sphere of modern society, underscoring its many shortcomings. While not negating these problems, this chapter suggests that TV (and popular culture) offer opportunities for audiences to air, process, and make political sense of changing cultural horizons, norms, and values.

This research paper analyses and assesses the impacts of the Israeli imposed physical obstructions on the mobility of the Palestinians in the West Bank, using a case study focused on the Bethlehem – Ramallah route. Arguably, the prevailing Israeli imposed physical obstructions, or mobility restrictions, in the West Bank territory have negative implications on the articulation of sustainable Palest

Weak subdivision or fragmentation ability of deformed {100} (<100> // ND, normal direction) grains by traditional unidirectional (symmetric) rolling results in uneven deformation during tantalum (Ta) processing. Thus, a recently developed asymmetric cross rolling (ACR) is adopted in this work to enhance the subdivision of {100} grain in Ta sheets. Electron backscatter diffraction (EBSD), transmiss

Critical infrastructure systems must be both robust and resilient in order to ensure the functioning of society. To improve the performance of such systems, we often use risk and vulnerability analysis to nd and address system weaknesses. A critical component of such analyses is the ability to accurately determine the negative consequences of various types of failures in the system. Numerous mathe

BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based stu

In recent years, second language acquisition research has focused on the performance of advanced and pre-advanced L2 learners (non-native speakers; henceforth NNSs), the former having received less attention. The present study draws on dialogues about future plans and route directions between advanced NNSs and a single native speaker (EVA). It is hypothesized that a NNS needs more time to construc

Several serum and urine biochemical markers of bone resorption and formation have been developed. Biochemical bone markers have been used as intermediate end-points in all major studies of anti-osteoporotic therapies. Bone resorption markers, in particular, may add an independent, predictive value to the assessment of bone loss and fracture risk. There are also potential advantages in monitoring a

A quantitative methodology based on in-line UV/Vis absorption spectroscopy and on-line evaporative light scattering detection for supercritical fluid extraction is proposed. The method was applied to the extraction of carotenoids, chlorophyll A, ergosterol and total lipids from microalgae. One regression technique and two curve resolution techniques were applied on the absorption spectroscopy data

RF and DC characterization of vertical InAs nanowire MOSFET on Si substrates are presented. Nanowire arrays are epitaxially integrated on Si substrates by use of a thin InAs buffer layer. For device fabrication, high-k HfO2 gate dielectric and wrap-gates are used. Post-deposition annealing of the high-k is evaluated by comparing one annealed and one not-annealed sample. The annealed sample show be