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CRISPR/Cas9 induced overexpression of GABA receptor α1-subunit and CB1 receptor

Epilepsy is one of the most common neurological diseases that affects 1 % of the human population. After an initial insult, the brain undergoes several changes that lead to hyperexcitability. These changes include downregulation of both GABAA receptor subunits and CB1 receptors. These receptors normally work to decrease excitability, so their downregulation leads to an increase in excitability. If

Analysis of list creation with machine learning

Detta examensarbete utforskar listgenerering med hjälp av maskininlärning inom IKEA. Avhandlingsarbetet involverade informationsinsamling, planering, studier av maskininlärning koncept, skapande av ett konceptbevis (POC) och analys av resultaten. Den tekniska bakgrunden byggdes på litteratur genomgångar och praktiska färdigheter genom maskininlärning kurser som Google's "Machine Learning This Bachelor’s Thesis delves into the category of list generation using machine learning within IKEA. The thesis work involved information gathering, planning, studying machine learning concepts, creating a proof of concept (POC), and analyzing the results. The Technical Background was built upon literature reviews and practical skills acquired through Machine learning courses such as Google’s “M

Med stereotypen som utgångspunkt: en studie om knivlagens tillämpningsproblematik

A knife is a tool which is used for both in- and outdoor purposes. Although wearing a knife in public areas is criminalized by Swedish law, the regulation includes several reservations about dispensations of judgement if the wearing is considered to be legitimated. The purpose of this study is to investigate and discuss the potential difficulties with the legal practice of the prohibition of knife

LLVM-Based Fortification for Kernel Drivers

In today’s operating systems, drivers are linked with the kernel where handling pointers and performing memory accesses must be considered with much more care than in application user space. This thesis focuses on two issues. First, memory access to user space must never be done directly, because the access may fault due to insufficient access permissions or unmapped pages. Second, pointers enter

Using the Go Programming Language in Practice

When developing software today, we still use old tools and ideas. Maybe it is time to start from scratch and try tools and languages that are more in line with how we actually want to develop software. The Go Programming Language was created at Google by a rather famous trio: Rob Pike, Ken Thompson and Robert Griesemer. Before introducing Go, the company suffered from their development process no

Keeping up the PICUP

The aggregation of α-synuclein into fibrils has been long proven to be closely related to the toxicity leading to Parkinson’s disease. In this process, medium-sized intermediates called oligomers are formed, a heterogeneous group of aggregates formed by a small number of monomers. While fibrils have been proven to cause little to no toxicity, oligomers have been demonstrated to induce cell death.

Klandergrunden handläggningsfel – en för parterna svårligen förutsebar bestämmelse? – En studie av innehållet i 34 § 1 st. 7 p. lagen om skiljeförfarande samt en utblick mot grova rättegångsfel i civilprocessen

Skiljeförfarande som tvistlösningsform har blivit allt vanligare mellan kommersiella parter, till stor del på grund av dess effektivitet och slutgiltighet. Skiljedomar kan enbart upphävas enligt ett begränsat antal grunder i 34 § 1 st. lag (1999:166) om skiljeförfarande (LSF). En av dessa klandergrunder kan åberopas om skiljenämnden begått ett handläggningsfel utan parts vållande som sannolikt påvCommercial arbitration has become increasingly common in Sweden mostly due to its effectiveness and finality as a mechanism for solving disputes. However, according to the Swedish Arbitration Act of 1999 (SAA), arbitration awards can only be set aside in a limited number of situations. One of the situations when it is possible to set aside an award is when an arbitration tribunal has made a proced

Tolka, anpassa och motivera -En kvalitativ studie om socialsekreterares erfarenheter om insatsen kontaktfamilj

The aim of this study was to examine social workers experience on the Swedish statutory regulated program “contact family”. A contact family is a non-compulsory intervention to support children in families with social problems. The intervention contact family together with the intervention contact person is the most common non-compulsory intervention in the Swedish social service. The child lives

Doppelgänger students and cast shadows: An updated archetypal analysis of the doppelgängers Mr. Hyde and William W2

This paper is a proposition of how to use an archetypal analysis based on new theoretical concepts of the Jungian archetypes, such as the image schema (Knox, 2001), the bi-polarity of complexes (Perry, 1970), and the culture complex (Singer, 2006). Consequently, these are combined with the cognitive schema theory, cues and the cultural frame switch theory. Furthermore, these theories are connected

Trovärdigheten för värderingsdrivna marknadsföringsinitiativ

Syftet med undersökningen är att få en djupare förståelse för vad värderingsdrivna marknadsföringsinitiativ genererar i relation till trovärdigheten för hållbarhetsarbete ur ett konsumentperspektiv. Vidare ämnar studien att undersöka hur det tillämpas av ett varumärke inom fast fashion-industrin, i den sociala kontexten på Facebook och Instagram. Organisationen Gina Tricot har använts som ett empiThe aim of this thesis is to explore how the credibility for an organization's sustainability work is affected using value-driven marketing communication, communicated on Instagram and Facebook. Furthermore, the study intends to investigate how it is applied by a brand in the fast fashion-industry. The organization Gina Tricot has been used as an empirical example to conduct the analysis, base

Reparera eller konsumera? - En svensk strategi för en ökad andel reparationer

Reparera mera – en svensk möjlighet att förlänga livstiden på produkter Genom att reparera din produkt istället för att köpa en ny bidrar du till att råmaterial besparas, de globala ekosystemen bevaras och växthusgasutsläppen minskas – och du får dessutom möjlighet att bruka din produkt under en längre tid! Reparation utgör därmed en viktig del i omställningen från dagens linjära ekonomi, som byggTo reduce the use of resources, as well as to minimize the effluents of carbon dioxide; we need to use our products for a longer time. Repairs makes that possible and is considered a key strategy to move towards a more circular economy (CE). Sweden recently presented its CE action plan, which includes few direct initiatives that would foster repairs. Therefore, through a literature review, policy

Love in action - A deductive content analysis of Martin Luther King Junior’s conceptualization of human rights

Den här uppsatsen undersöker Martin Luther King Juniors roll inom och bidrag till fältet för mänskliga rättigheter, och syftet med uppsatsen är att undersöka och analysera hur Martin Luther King Junior uttryckte sin förståelse för mänskliga rättigheter som ett koncept. För att uppfylla uppsatsens syfte har en frågeställning formulerats som centrerar kring Martin Luther King Juniors konceptualiseriThe purpose of this thesis is to investigate the role and contribution of Martin Luther King Junior within the field of human rights, with a focus on how Martin Luther King Junior expressed his understanding of the concept of human rights from different perspectives. The purpose of the thesis is focused by the formulation of a research question that centres around Martin Luther King Junior’s conce

Temporary formworks as torsional bracing system for steel-concrete composite bridges during concreting of the deck

A critical stage for the construction of steel-concrete composite bridges occurs during casting of the bridge deck, when the wet concrete has still not hardened. The entire construction load is then taken by the non-composite steel sections. Bracing may be needed to make the slender girders rigid enough to resist lateral torsional buckling during this phase. If temporary formwork could be attached

Serviceability floor loads

Serviceability of structures has to be verified for a lower load level than the design load used for safety considerations. Representative values of actions used in serviceability load combinations are often defined in a way that the fraction of time spent above a given load level should be limited to a certain value. To determine these load levels more information on the stochastic nature of the

Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation

Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it seldom resolves completely. Studies of vascular involvement in asthma have main

Design of Robust PID Controllers with Constrained Control Signal Activity

This thesis presents a new method for design of PI and PID controllers with the level of control signal activity taken into consideration. The main reason why the D-part is often disabled in industrial control loops is because it leads to control signal sensitivity of measurement noise. A frequently varying control signal with too high amplitude will very likely lead to actuator wear and tear. For