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Background: The Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers.Objective: Validation of patient-reported HD by investigating the agreement between motor state assessments by patients and observers.Methods: This observational study included patients with PD and motor fluctuat

Background: The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods: From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute ches

In the Arctic and subarctic oceans, the relatively low supply of silicon (compared to other nutrients) can make it limiting for the growth of diatoms, a fundamental building block of the oceanic food web. Glaciers release large quantities of dissolved silicon and dissolvable solid amorphous silica phases into high-latitude estuaries (fjords), but the role of these glacially-derived silica phases i

Over the last decades, a body of feminist research (Angkjær Jørgensen & Åsebø 2020-2025, Freeman 2010, Halberstam 2022, Hemmings 2011, Tesfagiorgis 1993) has problematized established stories that chronicle the development of Western feminist movements’ recent past. Drawing from this strain of previous research, this paper is particularly influenced by a number of scholarly works that analyse Over the last decades, a body of feminist research (Angkjær Jørgensen & Åsebø 2020-2025, Freeman 2010, Halberstam 2022, Hemmings 2011, Tesfagiorgis 1993) has problematized established stories that chronicle the development of Western feminist movements’ recent past. Drawing from this strain of previous research, this paper is particularly influenced by a number of scholarly works that analyse

This study focuses on comparing three electrical machine (EM) topologies to be used in an electric vehicle powertrain. The considered topologies are the permanent magnet synchronous machine (PMSM), permanent magnet assisted synchronous reluctance machine (PMa-SynRM), and induction machine (IM). For this assessment, complete powertrains are optimized for each EM topology. A powertrain optimization

What is the form of natural selection on immune responsiveness? For a population at evolutionary equilibrium, there are two different scenarios. First, it is generally assumed that immune defense has both benefits and costs. If variation in immune responsiveness is due to variation in how individuals trade off these costs and benefits, one would expect immune responsiveness to be subject to stabil

A model of emotional conditioning is ex- tended with a cortical model where stimulus codes compete for activation. This system is combined with motivational inputs that mod- ulate both sensory and emotional processing. The extended model is able to reproduce the attentional blocking effect. It can also learn to switch between different sensory targets when the motivational state changes. The relat

Assuming there is a new gauge group in a Hidden Valley, and a new type of radiation, can we observe it through its effect on the kinematic distributions of recoiling visible particles? Specifically, what are the collider signatures of radiation in a hidden sector? We address these questions using a generic SU(N)-like Hidden Valley model that we implement in PYTHIA. We find that in both the e(+)e(-

Soil functions can be classified as supporting (nutrient cycling) and provisioning (crop production) ecosystem services (ES). These services consist of multiple and dynamic functions and are typically assessed using indicators, e.g. microbial biomass as an indicator of supporting services. Agricultural intensification negatively affects indicators of soil functions and is therefore considered to d

We describe recent developments of the public computer code HiggsBounds. In particular, these include the incorporation of LHC Higgs search results from Run 2 at a center-of-mass energy of 13 TeV, and an updated and extended framework for the theoretical input that accounts for improved Higgs cross section and branching ratio predictions and new search channels. We furthermore discuss an improved

The Swedish referendum on the euro in September 2003 is an exceptional event for researchers of monetary unions and of European economic integration. Voters chose between maintaining the domestic currency, the krona, and replacing it with the euro, the single currency of the European Union. The referendum revealed significant dividing lines between Yes- and No-voters in areas such as income, educaThe Swedish referendum on the euro in September 2003 is an exceptional event for researchers of monetary unions and of European economic integration. Voters chose between maintaining the domestic currency, the krona, and replacing it with the euro, the single currency of the European Union. The referendum revealed significant dividing lines between Yes- and No-voters in areas such as income, educa

Static analysis tools help developers find bugs, improve code readability, and ensure consistent style across a project. However, these tools can be difficult to smoothly integrate with each other and into the developer workflow, particularly when scaling to large codebases. We present Tricorder, a program analysis platform aimed at building a data-driven ecosystem around program analysis. We pres