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Hodgkin and Huxley's seminal neuron model describes the propagation of voltage spikes in axons, but it cannot explain certain full-neuron features crucial for understanding the neural code. We consider channel current fluctuations in a trisection of the Hodgkin-Huxley model, allowing an analytic-mechanistic explanation of these features and yielding consistently excellent matches with in vivo reco

JavaScript lets developers provide client-side interactivity in Web applications, but because it is sequential, it can't take advantage of multicore processors. Thread-level speculation (TLS) addresses this issue by enabling the speculation of JavaScript function calls and thus exploits the parallel performance potential multicore processors provide. The authors implemented TLS in the Squirrelfish

BACKGROUND: The aim of this study was to evaluate the measurement properties of the Arnetz and Hasson seven-item stress questionnaire in order to select high-risk freshmen for a stress and alcohol intervention research project. METHODS: Two complete cohorts of university freshmen at two universities were asked to participate in an intervention study. All subjects responded to seven Visual Analogue

This paper aims to provide a basis for renewed talk about “use” in computing. Four current “discourse arenas” are described. Different intentions manifest in each arena are linked to failures in ”translation,” different terminologies crossing disciplinary and national boundaries non-reflexively. Analysis of transnational use discourse dynamics shows much miscommunication. Conflicts like that betwe

A diffusion model of noninvasive absorption spectroscopy was used to determine how the change in signal resulting from a point absorber depends on the position of that absorber relative to the source and detector. This is equivalent to calculating the relative probability that a photon will visit a certain location in tissue before its detection. Experimental mapping of the point-target response i

In this study, we determined the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers to predict development of Alzheimer's disease (AD) within five years in patients with mild cognitive impairment (MCI). To do so, the levels of tau, phosphorylated tau, Abeta42, Abeta40, Abeta38, sAbetaPPalpha, and sAbetaPPbeta were analyzed in 327 CSF samples obtained at baseline from patients with AD (n=

Background: The Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers.Objective: Validation of patient-reported HD by investigating the agreement between motor state assessments by patients and observers.Methods: This observational study included patients with PD and motor fluctuat

Background: The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods: From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute ches

We present an experimental study of the kinematics of twist extrusion (TE) and show that TE has the following properties: (i) as in equal-channel angular pressing (ECAP), the mode of deformation in twist extrusion is simple shear. Unlike in ECAP, there are two shear planes; one of them is perpendicular and the other is parallel to the specimen axis. (ii) The following processes are present during

This paper presents a dataflow design methodology and an associated co-exploration environment, focusing on the optimization of buffer sizes. The approach is applicable to dynamic dataflow designs and its performance is presented and validated by experimental results on the porting of an MPEG-4 Simple Profile decoder to the STM STHORM manycore platform. For the purpose of this work, the decoder ha

The EU project ALVIS - Superpeer Semantic Search Engine, aiming at developing an Open Source prototype of a peer-to-peer, semantic based search engine, is brie°y presented. A focused (or topic speci¯c) crawler, responsible for creating topic-speci¯c databases within ALVIS, is presented in more detail. It is based on a combination of a standard Web crawler and an automated subject classi¯er. The to

Novel methodology for O-functionalization of carbohydrate derivatives has been established using bench-stable and easily prepared iodonium(III) reagents. Both electron-withdrawing and electron-donating aryl groups were introduced under ambient conditions and without precautions to exclude air or moisture. Furthermore, the approach was extended both to full arylation of cyclodextrin, and to trifluo

Highly efficient washing and extraction of microbeads to decomplex analytes ranging from small peptides to large viruses was realised in a microscaled continuous flow format. The bead washing principle reported herein is based on acoustophoresis, i.e. the primary acoustic radiation force in an ultrasonic standing wave and laminar flow properties are utilised to translate bioanalytes trapped on fun

Crop residues can be used for biogas production in farm scale reactors. Use of a process temperature below mesophilic conditions reduces the need for heating as well as investment and operating costs, although it may also reduce the methane yield. In the present study the effect of temperature on net energy output was studied using sugar beet tops and straw as substrates for two pilot-scale reacto

Insekters DNA i luften? På senare år har flera forskningsrapporter visat att olika insektgrupper drastiskt minskar i antal. Till följd av detta kan man även se att artkompositionen förändrats och att andra organismer som är beroende av insekter, antingen för pollinering eller som föda, också minskar i antal. För att kunna förstå varför dessa förändringar sker så krävs en kontinuerlig övervakning In the face of widely reported declines in insect abundance and diversity, there is a great need for faster and easier insect monitoring methods as the already established methods are time consuming and only target specific species groups. In this study I investigate if metabarcoding of eDNA samples collected from the air can i) detect and identify insect species, ii) help quantify spatial and tem