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Dimensions of trust in scholarly communication : problematizing peer review in the aftermath of John Bohannon’s ‘Sting’ in Science

This study investigates online material published in reaction to a Science magazine report showing the absence of peer-review and editorial processes in a set of fee-charging open access journals in Biology. Quantitative and qualitative textual analyses are combined to map conceptual relations in these reactions; and to explore how understandings of scholarly communication and publishing relate to

Mechanical Tensioning of High-Strength Aluminum Alloy Friction Stir Welds

The extent to which in-situ global mechanical tensioning (GMT) can be used to modify the residual stress state in friction stir (FS) welds is investigated in this article. Residual stress distributions have been determined by synchrotron X-ray and neutron diffraction for four sets of FS welds in high-strength AA7449-W51 and lithium containing AA2199-T8 aerospace aluminum alloys subjected to a syst

Hur bör en modern livsmedelsleverantör arbeta för att säkra sin position på marknaden? - en studie av det Svenska kommersiella restaurangsegmentet

Målet med denna studie är att utreda hur olika egenskaper hos leverantören prioriteras och värderas av den inköpsansvariga. Det är betydelsefullt för restaurangbranschens säljorganisationer att känna till på vilka grunder en restaurang fattar sina inköpsbeslut och hur man resonerar vid val av leverantör. Studien genererade ett antal variabler vilka livsmedelsleverantören bör studera och utvärdera,

United By Media?! : en netnografisk studie om hur Eurovisionfans förhåller sig till marknadsföringen av Eurovision Song Contest 2024 på Instagram

Medieevent har möjligheten att föra samman människor, men kan även leda till symboliska kamper mellan olika sociala grupper. Eurovision Song Contest är ett sådant event, där intresset för den europeiska sångtävlingen i sociala medier som Instagram är stort. Eftersom populärkultur och politik är svårt att särskilja i medieinnehåll som marknadsföring, och att fans dessutom kan engagera sig politiskt

En riktigt gapig shitshow : medborgarengagemang och civic culture på Flashback

I denna uppsats analyseras hur en civic culture kan förkroppsligas på det svenska digitala diskussionsforumet Flashback. Genom en kvalitativ innehållsanalys analyserades en diskussionstråd som refererade till en svensk TV-sänd partiledardebatt i SVT:s samhällsprogram Agenda. Det teoretiska ramverk som användes för att strukturera analysen var Peter Dahlgrens (2009) föreslagna sex dimensioner av ci

Volumetric intensity dependence on the formation of molecular and atomic ions within a high intensity laser focus

The mechanism of atomic and molecular ionization in intense, ultra-short laser fields is a subject which continues to receive considerable attention. An inherent difficulty with techniques involving the tight focus of a laser beam is the continuous distribution of intensities contained within the focus, which can vary over several orders of magnitude. The present study adopts time of flight mass s

Identifying Abnormal Exertional Breathlessness in COPD : Comparing Modified Medical Research Council and COPD Assessment Test With Cardiopulmonary Exercise Testing

Background: COPD management is guided by the respiratory symptom burden, assessed using the modified Medical Research Council (mMRC) scale, the COPD Assessment Test (CAT), or both. Research Question: What are the abilities of mMRC and CAT to detect abnormally high exertional breathlessness on incremental cardiopulmonary cycle exercise testing (CPET) in people with COPD? Study Design and Methods: A

Effects of long-term oxygen therapy on acute exacerbation and hospital burden : the national DISCOVERY study

BACKGROUND: Long-term oxygen therapy (LTOT) improves survival in patients with chronic severe resting hypoxaemia, but effects on hospitalisation are unknown. This study evaluated the potential impact of starting LTOT on acute exacerbation and hospital burden in patients with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and pulmonary hypertension (PH).METHODS: Longi

Accessing the proteome of extracellular vesicles via rapid acoustic isolation of a minute human blood plasma sample

Background: Despite substantial progress in the field of mass spectrometry, there remain barriers to measuring the extracellular vesicles (EVs) proteome in blood plasma. Recent work has shown that isolating EVs can make it possible to detect proteins that have low abundance in plasma. Commonly used EV isolation methods either require large sample volumes and long ultracentrifugation times, or else

Complications of ultrasound guided very small-bore chest drains for pleural effusions of different etiology

Background: Small-bore chest drains are now the most common drains for treating pleural effusion (PE), but knowledge on complications is limited especially in malignant PE and empyema. We aimed to evaluate rate of complications of ultrasound guided small bore chest drains [6–10 French (F)] by PE etiology. Methods: Retrospective cohort study of 484 chest drains inserted in 330 adults in a Swedish d

Data-driven microscopy allows for automated context-specific acquisition of high-fidelity image data

Light microscopy is a powerful single-cell technique that allows for quantitative spatial information at subcellular resolution. However, unlike flow cytometry and single-cell sequencing techniques, microscopy has issues achieving high-quality population-wide sample characterization while maintaining high resolution. Here, we present a general framework, data-driven microscopy (DDM) that uses real

CRISPR editing of the PPARGC1A Gly482ser (rs8192678) polymorphism in human white adipose cells shows differential effects on mitochondrial function and adipogenesis.

Background and aims: PPARGC1A encodes PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1-α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipoc