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Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis

To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is assoc

Antibody-dependent allostery of the M1 protein

Den förrädiska antikroppen Streptokocker är en lömsk bakterie som har många olika sätt att ta sig runt vårt immunförsvar. Den kan låtsas vara en del av vår kropp genom att klä sig själv i en proteinkapsel som är väldigt likt ett mänskligt protein, bryta ned våra celler med hjälp av utsöndrade gifter och använda vårt immunförsvar mot oss genom att binda antikroppar till sig själv. En virulensfaktoThe Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands

In-Store Recycling - A Consumer Perspective

Syftet med uppsatsen är att studera hur ett segment av Generation Y ser på in-store recycling - en tjänst myntad av författarna till arbetet. In-store recycling är en tjänst som många fast fashion retail-bolag har börjat erbjuda genom att placera insamlingslådor för kläder som konsumenter vill ha återvunnet eller återanvänt, och i retur får konsumenten en belöning i form av en rabattkupong. För at

Purification of streptococcal protein G expressed by Escherichia coli by high performance liquid affinity chromatography using immobilized immunoglobulin G and albumin

A one-step HPLC method was developed for the purification of protein G, a cell wall molecule from group C and G streptococci with immunoglobulin G- and albumin-binding properties. Lysed Escherichia coli bacteria infected with lambda-phages containing the protein G gene from group G streptococci were used as a starting material for the preparations. The lysate was applied to a column with immobiliz

Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructures

Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amino acid sequence of more than 75 amino acids (aa 552-635) for antibody binding. We

In search of a model for sustainable innovation in welfare services

Paper for the Public and Social Innovation Conference (PUBSIC), Lillehammer University College, Lillehammer, Norway, 15-17 November, 2017 Theme 7B: managing and evaluating sustainable innovation In search of a model for sustainable innovation in welfare services Katja Lindqvist & Ulrika WestrupDepartment of Service Management and Service Studies, Lund University, Swedenkatja.lindqvist@ism.lu.s

Schema MNXD11 HT22 220628 sista Versionen

Schema höstterminen 2022 Kurs: MNXD11 Hållbar utveckling för jorden, livet och miljön Kursansvarig: Helena Hanson Lokaler: Zoom Litteratur: Se separat lista Studieteknik: Läs om studieverkstaden Studenträttigheter: Läs om dina rättigheter och skyldigheter som student Likabehandling: Läs Lunds Universitets likabehandlingsplan för studenter Pedagogiskt stöd: Läs om pedagogiskt stöd vid funktionshind

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2022-07/Schema%20MNXD11%20HT22_220628_sista%20versionen.pdf - 2026-06-22

Redox control of exocytosis - Regulatory role of NADPH, thioredoxin, and glutaredoxin

Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel