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Sialyl-Tn (STn or sialyl-Thomsen-nouveau) is a carbohydrate antigen expressed by more than 80% of human carcinomas. We here report a strategy for ratiometric STn detection and dual-color cancer cell labeling, particularly, by molecularly imprinted polymers (MIPs). Imprinting was based on spectroscopic studies of a urea-containing green-fluorescent monomer 1 and STn-Thr-Na (sodium salt of Neu5Acα2-
BACKGROUND: Anastomotic leakage after rectal cancer surgery is linked to reduced survival and higher recurrence rates. While an aggravated inflammatory response may worsen outcomes, few studies have explored the combined effects of leakage and inflammation.METHODS: This is a retrospective multicenter cohort study including patients operated with anterior resection for rectal cancer in Sweden durin
Background and Objective: This narrative review addresses idiopathic acute pancreatitis (IAP) and its epidemiology, diagnosis, clinical course and treatment during the last decade. As there is no previously validated protocol for finding the aetiology of acute pancreatitis (AP), the primary aim of this study is to find, describe and unify evidence about the diagnostic work-up of AP to diagnose the
The global energy landscape is entrenched in fossil fuels, shaping modern life profoundly. Germany, a prominent example, grapples with transitioning from its fossil-fuelled infrastructure despite governmental support for decarbonization. Carbon capture and storage (CCS) and hydrogen appear as crucial tools in this transition. A recent partnership between Germany and Norway seeks to leverage Norway
Background and Objectives Structural brain MRI and blood-based phosphorylated tau (p-tau) measures are among the least invasive and least expensive Alzheimer's disease (AD) biomarkers to date. The extent to which these biomarkersmay outperformone another in predicting future Alzheimer dementia diagnosis is poorly understood, however. This study investigated 2 specific AD biomarkers, i.e., a cortic
In dynamic operational environments, particularly in collaborative robotics, the inevitability of failures necessitates robust and adaptable recovery strategies. Traditional automated recovery strategies, while effective for predefined scenarios, often lack the flexibility required for on-the-fly task management and adaptation to expected failures. Addressing this gap, we propose a novel approach
The invasive golden apple snail Pomacea canaliculata is one of the devastating threats to aquatic ecosystems and wetland agriculture worldwide. Macrolides from microbes display various advantages over other compounds in controlling snails. However, emergence of antibiotic-resistant phenotypes against certain macrolides in the field appeals for exploring more effectively molluscicidal macrolides. H
Both phosphoryl and sulfuryl transfers are ubiquitous in biology, being involved in a wide range of processes, ranging from cell division to apoptosis. Additionally, it is becoming increasingly clear that enzymes that can catalyze phosphoryl transfer can often cross-catalyze sulfuryl transfer (and vice versa). However, while there have been extensive experimental and theoretical studies performed
Context: Contemporary patients with primary hyperparathyroidism are diagnosed with milder disease than previously. Clinical and biochemical factors predictors with an impact on fracture incidence and bone mineral density after surgery have not been firmly established. Objective: To investigate predictors of fracture incidence and bone mineral density preoperatively and after surgery for primary hy
Women have made substantial gains in education in recent decades and outperformmen in educational attainment across the OECD, but the consequences of this reversal of the gender gap in education (RGE) have not been well researched. In this study, we address the association between the RGE and partnering, employment, and support for a right-wing populist party in Sweden. Of note, we explore the dif
Women have made substantial gains in education and outperform men regarding educational attainment across the OECD, but the consequences of this reversal of the gender gap in education (RGE) have not been well researched. We address the association between the RGE and partnering, employment, and support for a right-wing populist party in Sweden. We explore the differential impacts of women's educa
Following the upgrade of the LNLS injector system with the addition of a 500 MeV booster synchrotron, the storage ring in vacuum ferrite injection kicker magnets started to show overheating due the interaction with high frequency electromagnetic fields induced by the electron beam in large currents. In this paper, we describe the design of a new ceramic chamber for the kickers, which minimize this
Children's outdoor play and access to nature are important for their health and development of environmental agency but there is a global decline of green spaces available to them. The aim is to explore the possibilities of creating nature-based outdoor settings for play and learning which benefit children as well as the wildlife and wider ecosystems. A fieldwork on developing nature based play se
Echinolittorina malaccana, a marine gastropod living on rocky shores along the Indo-West Pacific coasts, shows consistent mate choice in which males prefer to mate with females slightly larger than themselves. Previous studies suggest that the strength of this preference is, to a certain extent, context dependent, being influenced by both demographic and individual (potentially genetic) factors. T
While the Convention on the Rights of the Child (UNCRC) does not address research, it instigated a recognition that decisions concerning children and youth must be based on knowledge of their experiences from their own perspective and consider their specific views and wishes, highlighting their right to be heard. Participatory research underscores this right, arguing the engagement of children and
Energy management in urban areas is challenging due to diverse energy users, dynamics environmental conditions, and the added complexity and instability of extreme weather events. We incorporate adaptive reinforcement learning (ARL) into energy management (EM) and introduce a novel approach, called ARLEM. An online, value-based, model-free ARL engine is designed that updates its policy periodicall
To increase women’s interest in STEM (Science, Technology, Engineering and Mathematics), interventions that target self-efficacy and belongingness are needed. For this purpose, this study designed and tested two interventions. In Study 1, we tested if a video with female role models increases young women’s expected belongingness and interest in engineering. In Study 2, we tested if positive feedba
The distinguishing feature of frequency diverse array (FDA) systems as compared to conventional phased-array and multiple-input multiple-output (MIMO) radar systems is the use of a small frequency offset (FO) across the array elements. Much of the development to date has focused on the FDA-MIMO structure, using an FO that is larger than the bandwidth of the baseband signal, thereby reducing the re
High-throughput screening (HTS) three-dimensional (3D) tumor models are a promising approach for cancer drug discovery, as they more accurately replicate in vivo cell behavior than two-dimensional (2D) models. However, assessing and comparing current 3D models for drug efficacy remains essential, given the significant influence of cellular conditions on treatment response. To develop in vivo mimic
