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Deaths of despair (DoD), encompassing suicide, drug overdose, and alcohol-related mortality, are often linked to social and psychological distress. This study examined the long-term risk of DoD among individuals previously hospitalized for suicide attempts, with a focus on substance use problems and psychiatric disorders as potential risk factors. A prospective cohort of 1044 individuals admitted

Purpose of review Breathlessness is a common, distressing and limiting symptom in people with advanced disease, but is challenging to assess as the symptom intensity depends on the level of exertion (symptom stimulus) during the assessment. This review outlines how to use recently developed normative reference equations to evaluate breathlessness responses, accounting for level of exertion, for va

AimsWe aimed to investigate the association between the exercise systolic blood pressure (SBP) response and future hypertension (HTN) in normotensive individuals referred for cycle ergometry, with special regard to reference exercise SBP values and exercise capacity.Methods and resultsIn this longitudinal cohort study, data from 14 428 exercise tests were cross-linked with Swedish national registr

Background: Swedish healthcare is in a period of transition with an expanding private sector. This study compares quality of outcome after groin hernia repair performed in a public or private healthcare setting. Methods: A cohort study based on data from the Swedish National Hernia Register combined with Patient-Reported Outcome Measures (PROMs) 1 year after groin hernia repair. Between September

Flowing water impacts bridges over rivers primarily in two ways: (1) hydrodynamic forces that directly impact the structure and (2) scouring at piers and abutments, including contraction scour. The design prin-ciples for bridges in Sweden, including both impacting forces and local scour, are relatively simplistic. The purpose of this paper is to examine the impact of extreme river flows on bridges

Feathers comprise a series of evolutionary innovations but also harbour colour, a key biological trait known to co-vary with life history or complex traits. Those relationships are particularly true in melanin-based pigmentation species due to known pleiotropic effects of the melanocortin pathway – originating from melanin-associated phenotypes. Here, we explore the molecular basis of melanin colo

Wave climate data for the Swedish provinces Skane and Halland, were hindcast using SWAN, a third-generation spectral wave model. The 40-year wave dataset, from 1979 to 2019, is made available through an open-access data portal (https://gis.sgi.se/vagmodell/). The wave data has a three-hour resolution and includes significant wave height, peak wave period, and wave direction. The wave model domain

Many iterative optimization algorithms involve compositions of special cases of Lipschitz continuous operators, namely firmly nonexpansive, averaged, and nonexpansive operators. The structure and properties of the compositions are of particular importance in the proofs of convergence of such algorithms. In this paper, we systematically study the compositions of further special cases of Lipschitz c

Background: Women are at increased risk of developing anxiety or depression disorders after Cesarean section (CS). This study aims to evaluate whether an appointment with a senior obstetrician combined with an ultrasound examination reduces levels of anxiety in women after CS. Methods: A prospective observational study was conducted in Sweden. Women underwent an appointment with an obstetrician 6–

A microenvironment is an area with a specific composition of mainly extracellular matrix (ECM) components surrounding the cells. The tight interactions between matrix molecules and cells are very important, and it is now well known that the ECM components direct cell activity and function and regulate remodeling processes during both homeostasis and pathological conditions. The lung is a very comp

Knowledge in statistics is essential to draw solid conclusions from data. This chapter covers the basic concepts needed to navigate in the world of biostatistics, with the aim that the reader should know what to search for when encountering new situations. First, the chapter introduces basic concepts such as scales of measurement, relation between sample and population, and features of stochastic

It was believed that Cdk2-cyclin E complexes are essential to drive cells through the G1-S phase transition. However, it was discovered recently that the mitotic kinase Cdk1 (Cdc2a) compensates for the loss of Cdk2. In the present study, we tested whether Cdk2 can compensate for the loss of Cdk1. We generated a knockin mouse in which the Cdk2 cDNA was knocked into the Cdk1 locus (Cdk1Cdk2KI). Subs

We argue that there is a need for a more elaborate and sophisticated discussion of if, and then how, the public library fulfils its social role to con- tribute to democracy. Therefore, we have formed the Lund Critical Library Studies group with a shared interest of contributing to a more nuanced and rich discussion about public libraries. This allows us to engage in discussions on how the library

The study makes an inventory of learning opportunities young people were offered in connection with CEI 2016, one of the annual international conferences organized by the NGO named Caretakers of the Environment International (CEI), which year 2016 took place in Aalborg in Denmark. The learning opportunities offered by this transnational learning community are discussed in relation to some essentia

Parkinson's disease (PD) is a neurodegenerative disease with unknown etiology. Here we show the generation of an induced pluripotent stem cell (iPSC) line, named CSC-40, from dermal fibroblasts obtained from a 59-year-old male patient with a homozygous p.Q456X mutation in the PTEN-induced putative kinase 1 (PINK/PARK6) gene and a confirmed diagnosis of PD, which could be used to model familial PD.