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Introduction: The use of pharmacokinetic assessment for optimal prophylactic dosing of factor concentrates in haemophilia has gained increasing enthusiasm over the last decade. However, blood sampling on several occasions is burdensome and limited sampling using population-based PK is appealing. Aim: To compare the pharmacokinetics and dosing recommendations for prophylaxis using six-point single
Crowdfunding offers a new potential source of financing of sustainability initiatives and the Sustainable Development Goals (SDGs) in particular. Such funding support is potentially even more important given the impacts of COVID-19 on the global economy. However, little theoretically based work has been conducted on sustainability crowdfunding. Therefore, this study builds and tests an integrated
Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur in the injured human brain and be implicated in the neurodegenerative aftermath of
Recent studies show that behaviour changes can provide an essential contribution to achieving the Paris climate targets. Existing climate change mitigation scenarios primarily focus on technological change and underrepresent the possible contribution of behaviour change. This paper presents and applies a methodology to decompose the factors contributing to changes in per capita emissions in scenar
Here, we present a revised protocol to derive neuroepithelial stem (NES) cells from human induced pluripotent stem cells. NES cells can be further differentiated into a culture of neurons (90%) and glia (10%). We describe how to derive and maintain NES cells in culture and how to differentiate them. In addition, we show the potential use of NES cells to study the role of reactive oxygen species in
Compared to other organisms in which the fatty acyl desaturases (FADs) are mostly involved in normal cellular lipid metabolism, moth FADs have evolved extent functions in the biosynthesis of sex pheromones. Female moths releasespecies-specific sex pheromones to attract conspecific males over a long distance for mating. Moth FADs are key enzymes producing the great diversity of moth sex pheromones.
In this work, a combination of sonication and carbon dioxide expanded liquid extraction (SA-CXLE) is used for the first time for the extraction of lipids from berry seeds. Three solvents (ethanol, methanol and ethyl lactate) are screened for the best recoveries of total lipids. Ethanol is selected due to its efficiency, greenness and sustainability. The effects of operation variables including tem
Background: Analysis of sialic acid (SA) metabolites in cerebrospinal fluid (CSF) is important for clinical diagnosis. In the present study, a high-performance liquid chromatography-tandem mass spectrometry (HPLC/MS/MS) method for free sialic acid (FSA) and total sialic acid (TSA) in human CSF was validated. Methods: The method utilized a simple sample-preparation procedure of protein precipitatio
Background: National guidelines are important instruments in reducing inappropriate antibiotic prescriptions. Low adherence to guidelines is an acknowledged problem that needs to be addressed. Method: We evaluated established characteristics for guidelines in the guidelines for lower respiratory tract infection, acute otitis media and pharyngotonsillitis in primary care. We studied how doctors use
Progresses in reconstructing Earth's history of biomass burning has motivated the development of a modern charcoal dataset covering the last decades through a community-based initiative called the Global Modern Charcoal Dataset (GMCD). As the frequency, intensity and spatial scale of fires are predicted to increase regionally and globally in conjunction with changing climate, anthropogenic activit
Background: It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs). After exposure, an early response to DSBs is the phosphorylation of the histone H2AX molecule regions adjacent to the DSBs, referred to as γ-H2AX foci. The γ-H2AX assay after external exposure is a good tool for investigating the link between the absorbed
Friction, wear, and emission performance strongly depend on the contact pressure and area at the interface of the pad and disc. The contact situation at the pad-to-disc interface can be explained by the formation and destruction of mesoscopic sized contact plateaus on the pad surface. Experimental studies report that the initial surface roughness of cermet-coated discs strongly affects friction, w
Enzymes active on glycosidic bonds are defined according to the stereochemistry of both substrates and products of the reactions they catalyze. The CAZy classification further assigns these enzymes into sequence-based families sharing a common stereochemistry for substrates (either α- or β-) and products (i.e., inverting or retaining mechanism). Here we describe the N-acetylgalactosaminidases AmGH
Viable city logistics are built on a sound business model that considers the financial viability and performance, and the role of externalities and stakeholders. To this end, the purpose of this dissertation is to increase understanding of how a business model can contribute to achieving viable city logistics initiatives.The research presented is qualitative and consists of three studies and five
Novel oxygen-deficient double-perovskite type oxide Ba2NixCo2−xO6 was applied to produce O2/CO2 mixed stream gas for oxyfuel combustion application. A series of different Co concentration substituted Ba2NixCo2−xO6 was synthesized by an EDTA-citrate sol-gel combustion method. The oxygen carriers, Ba2Ni0.25Co1.75O6, Ba2Ni0.45Co1.55O6, Ba2Ni0.65Co1.35O6 and Ba2Ni0.85Co1.15O6 were c\characterized by s
Marine mammals and coastal fisheries are two features commonly associated with thriving marine environments, but it is also a case of wildlife impact on human interests. This paper analyses the seal-fisheries encounter in a Swedish Baltic Sea fishery. The problem concerns seals eating fish from the fishing gear which causes considerable economic losses to small-scale fishermen. This mixed-method s
BACKGROUND: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associ
