Filtyp
Tendon function and homeostasis rely on external loading. This study investigates the biological mechanisms behind tendon biomechanical function and how the mechanical performance is affected by reduced daily loading. The Achilles tendons of 16 weeks old female Sprague Dawley rats (n = 40) were unloaded for 5 weeks by inducing muscle paralysis with botulinum toxin injections in the right gastrocne
Over the past decade, a massive increase in the use of nanomaterials and nanoparticles (NPs) in both commercial and medical applications has occurred. Medical applications include advanced drug delivery vehicles, imaging and hyper thermic therapies. In retinal research, several nanomaterials have been explored in novel treatment approaches, ranging from metals, carbon, polymers and silica to biolo
Popular Abstract in Swedish För att celler ska kunna växa och dela sig behöver de många olika ämnen, till exempel vitaminer, mineraler och polyaminer. Polyaminer finns i alla celler och de krävs för att cellerna ska kunna dela eller specialisera sig. Cellerna kan både själva tillverka polyaminer och ta upp dem från omgivningen. I mänskliga celler finns framför allt de tre polyaminerna putrescin, sOur research group has previously shown that treatment with the polyamine biosynthesis inhibitors a-difluoromethylornithine (DFMO) or amidinoindan-1-one 2´-amidinohydrazone (CGP 48664) inhibited S phase progression before any other cell cycle phase was affected. This study was undertaken to further investigate the role of polyamines in the regulation of S phase progression and DNA synthesis. I hav
Organizational routines that are critical to learning, flexibility, and adaptation explain the behaviour of the business organization. When organizational routines cross the boundary of the organization, variability and stability are affected. This study emphasizes organizational routines committed in specific outsourcing or insourcing situations to clarify the dynamics of organizational routines
Manual software testing is a widely practiced verification and validation method that is unlikely to fade away despite the advances in test automation. In the domain of manual testing, many practitioners advocate exploratory testing (ET), i.e., creative, experience-based testing without predesigned test cases, and they claim that it is more efficient than testing with detailed test cases. This pap
Amplification of the MYCN oncogene is strongly associated with poor prognosis in neuroblastoma (NB). In addition to MYCN amplification, many studies have focused on identifying patients with a poor prognosis based on gene expression profiling. The majority of prognostic signatures today are comprised of large gene lists limiting their clinical application. In addition, although of prognostic signi
The anaphylatoxin C3a is a proinflammatory mediator generated during complement activation. The tight control of C3a receptor (C3aR) expression is crucial for the regulation of anaphylatoxin-mediated effects. Key factors regulating constitutive expression of the C3aR in the mast cell line HMC-1 and receptor induction by dibutyryl-cAMP in monomyeloblastic U937 cells were determined by functional ch
The maximum efficiency of an optically thin photosynthetic system in converting solar radiation into chemical energy is theoretically considered as a function of the absorption spectrum of the photon-collecting pigment. The absorption band position giving maximum rate of power conversion is close to 700 nm in full sunlight and at somewhat shorter wavelength in weaker light. The chemical potential
The transition model (i) of classical phonetics distinguished between inevitable transitions between momentary target configurations (called coarticulation by Menzerath and Lacerda in 1933) and assimilation extending over a larger domain than a transition, implying reorganization of the input. By the 1950s it was clear that coarticulation extended beyond target configurations and involved more tha
Tubal factor infertility is often diagnosed without any documented history of pelvic inflammatory disease. Chlamydial infection is one of the most common causes of pelvic inflammatory disease and likely also of infertility and ectopic pregnancy. Oral contraceptives may alter the course of chlamydial infections which may mask the clinical expression of the disease. This paper considers a number of
The phylogenetic positions of the 4 clades, Euarchontoglires, Laurasiatheria, Afrotheria, and Xenarthra, have been major issues in the recent discussion of basal relationships among placental mammals. However, despite considerable efforts these relationships, crucial to the understanding of eutherian evolution and biogeography, have remained essentially unresolved. Euarchontoglires and Laurasiathe
