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BACKGROUND: Melanoma is a highly heterogeneous disease, and a deeper molecular classification is essential for improving patient stratification and treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover molecular subtypes and clinically relevant biomarkers.METHODS: We performed an integrative proteogen
BACKGROUND: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translation, have emerged as critical drivers of melanoma progression and therapy resistance. This study investigates the mitochondrial proteome in melanoma to uncover no
Under de senaste åren har antalet vårdnadstvister som avgjorts i domstol ökat markant i Sverige. Samtidigt har Sverige blivit ett mer mångkulturellt samhälle med en ökad arbetskraftsinvandring och kontinuerliga flykting- strömmar. I dagsläget har fler familjer än någonsin anknytning till utlandet vilket förstärker vissa problem inom familjerätten. Flera barn blir varje år olovligen bortförda ifrånIn recent years, the number of custody disputes settled in court has increased significantly in Sweden. This as a consequence of that Sweden has become a more multicultural society with increased labor migration and continuous refugee flows. Currently, more families than ever have links with foreign countries, which reinforces certain problems within family law. Several children are unlawfully abd
I dagens digitaliserade samhälle möter utgivare och publicister av traditionellt tryckt media stora ekonomiska motgångar vid försäljningen av exempelvis nyhetstidningar eller andra tidskrifter. Således har majoriteten av utläggare idag gjort sina publikationer tillgängliga för läsare online. De digitala intäkterna lyckas dock inte väga upp för de förluster utgivarna lider av den nedåtgående försälIn today's digitized society, publishers of legacy printed media face major financial hardships in the sale of newspapers and other magazines. Thus, most publishers today have made their publications available to readers online. However, digital revenues do not make up for the losses that the publishers suffer from the decreasing sales of printed media. This can in part be attributed to the fa
This thesis investigates the impact of U.S. sanctions imposed between 2010 and 2012 on Iran’s non-oil exports. Using the Synthetic Control Method (SCM) as the baseline strategy, complemented by an Event Study and a standard Difference-in-Differences (DiD) model, the analysis shows that sanctions led to a sharp and persistent decline in Iran’s export performance relative to a counterfactual scenari
The Second Battle of Passchendaele (October 26 - November 10, 1917) remains one of the most enduring symbols of the Canadian experience in the First World World, yet its historical prominence contrasts with a limited comprehension of the geographic realities faced by the soldiers. This gap stems largely from the absence of geographic contextualization in teachings of military history, compounded b
Denna uppsats behandlar EU:s nya regler som förändrar kravet på prospekt - ett detaljerat informationsdokument som företag måste publicera när de erbju-der aktier till allmänheten eller noterar dem på en marknadsplats. Prospektet skyddar investerare genom att ge klar information om företaget, aktierna och riskerna, så att de kan fatta välgrundade beslut. Uppsatsen fokuserar på "tröskelvärdet&This essay discusses how the EU's new regulations change the requirement for prospectus - a detailed information document that companies must publish when offering shares to the public or listing them on a marketplace. The prospectus protects investors by providing clear information about the company, the shares, and the risks, enabling them to make well-informed investments. The essay focuses
Particle induced oxidative stress is a probable pathway for many of the detrimental health-effects caused by particulate matter (PM). Recent studies on the exposure to oxidative potential (OP) in ambient fine and coarse PM suggest that anthropogenic particle pollutants, especially vehicular wear, anthropogenic primary and secondary organic aerosols (SOA) are more toxic on mass basis and more relev
The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb
Japan’s problem of vacant homes has drawn global media attention, but the situation may not be as dire as once predicted. While a 2015 report estimated a vacancy rate of 20.1 per cent by 2023, the actual figure was 13.8 per cent, thanks in part to policy reforms, awareness campaigns and grassroots efforts. Yet challenges remain amid an ageing population. Japan’s evolving approach offers valuable l
The principal fate during litter decomposition and mineralization is rather well established only for a limited number of elements, mainly essential plant nutrients and a few potentially very toxic metals. Elements which occupy the majority of the positions in the periodical system seems almost unknown in this context. The objectives were, therefore to assess differences in the behavior of 58 mine
To study the active sites of dinuclear metallohydrolases new metal complexes that model these sites both in structure and function have been synthesized using two new phenol based dinucleating ligands, 2-(N-isopropyl-N-((2-pyridyl)methyl)aminomethyl)-6-(N-(carboxylmethyl)-N-((2-pyridyl)methyl)aminomethyl)-4-methylphenol (IPCPMP) and 2,6-Bis[N-(N-(carboxymethyl)-N-(pyridylmethyl)amine)methyl]-4-met
7,3 miljoner flickor under 18 år föder varje år. En av tre flickor i länder med låg- eller medelinkomst kommer att gifta sig före 18 års ålder. Detta är en kränkning mot flickor och deras mänskliga rättigheter. United Nations Population Fund, UNFPA arbetar med att stärka kvinnors och unga människors möjligheter att leva ett hälsosammare och ett mer produktivt liv. Med detta i åtanke är syftet att
Under metoo-hösten år 2017 publicerade pressen namn på flera kända män som blivit anklagade för olika typer av sexualbrott. En av dessa män var stjärnjournalisten Fredrik Virtanen som från en dag till en annan pekades ut som våldtäktsman i Sveriges största tidningar. Pressen publicerade namn och detaljer om anklagelserna, trots att anklagelserna grundades på bristfällig bevisning. Hur kunde detta
Dealing with water diffuse pollution is a major problem for watershed managers. This problem raises many complicated questions, which are important to answer in order to reach water environment protection goals. This study suggested some possible answers for the country of Lithuania. Among them were the identification of critical source areas, the identification of sensitive areas and the applicat
Efterfrågan på sockerrör har de senaste åren ökat i takt med att fler länder strävar efter att minska sitt beroende av fossila bränslen. Som en följd har antalet sockerrörsodlingar kraftigt ökat i Brasilien vilket medfört en oro inför vilka effekter denna omvandling av ursprunglig mark till sockerrörsodling har på lokala hydrologin och klimatet. I det här arbetet har påverkan av sockerrörs expanThe demand for sugarcane has increased in recent years as more countries desire to reduce its dependence of fossil fuels. Therefore, the number of sugarcane plantations has rapidly increased in Brazil which raises concerns for what effect these conversion of original land to sugarcane plantations have on local hydrology and climate. In this thesis, the effects of sugarcane expansion on surface ru
Enligt artikel 1 i den Europeiska konventionen för de mänskliga rättigheterna och de grundläggande friheterna (EKMR) måste de fördragsslutande staterna inom ramen för sin jurisdiktion garantera konventionens fri- och rättigheter. Denna skyldighet är främst territoriell, men i exceptionella fall medges vissa undantag. Uppsatsen behandlar dessa undantag såsom de utvecklats i Europadomstolens praxis According to Article 1 of the European Convention on Human Rights and Fundamental Freedoms (ECHR) the contracting parties must secure the conventional rights within their jurisdiction. The obligation is primarily territorial but in exceptional cases it can be extended to apply extraterritorially. This paper will investigate the development of the case law of the European Court of Human Rights (the
