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Malaysian Educational Politics: ‘English Language Policy’ Implementation and Its Impact to Plural Society

This paper discuss the issue of ‘Teaching Mathematics and Science in English’ Policy implementation in Malaysia, which requires Mathematics and Science to be taught in an English medium in all primary schools, introduced by the government in May 2002. The needs of increased to overcome the declining standard of English contrasted with Malaysian plural society communal identity and mother tongue la

Preliminary Evidence of Efficacy and Target Engagement of Pramipexole in Anhedonic Depression

OBJECTIVE: To investigate feasibility and target engagement of high-dose, add-on pramipexole treatment in anhedonic depression.METHOD: In this open-label pilot study, we included 12 patients with unipolar or bipolar, moderate-to-severe depression and with significant anhedonia symptoms. All patients were on a stable dose of one or a combination of antidepressants and/or mood stabilizers and receiv

PSA quantification of 80 plasma samples from the clinical routine using antibody microarrays

Antibody microarrays are becoming increasingly established in clinical studies. However, the arrays are seldom used in a quantitative approach but rather for detecting up or down regulated proteins. In this study we describe a microarray procedure being standardized by placing the in-house developed porous silicon surfaces into a commercially available 96 well microtiter plate for analyzing the PS

Så skapar nanoteknik nya vägar till stamcellers inre

Forskare vid Lunds universitet har utvecklat en lovande nanoteknikbaserad metod för att leverera biomolekyler till mänskliga blodstamceller. Metodens förmåga att bibehålla cellernas funktion utan någon negativ påverkan har stor potential inom både grundforskning och kliniska tillämpningar. Här beskrivs den nya kunskapen av forskarna Ludwig Schmiderer, Jonas Larsson och Martin Hjort vid Lunds unive

CLOTHING REAL EVAPORATIVE RESISTANCE DETERMINED BY MEANS OF A SWEATING THERMAL MANIKIN: A NEW ROUND-ROBIN STUDY

The previous round-robin (RR) study on clothing evaporative resistance (Ret) has shown that the repeatability and reproducibility of clothing Ret measurements on sweating manikins were rather low. To further examine and enhance the measurement accuracy, a new strict but feasible test protocol was proposed and thoroughly examined in a new round-robin test. Eight laboratories participated in this st

Fever therapy in febrile adults : systematic review with meta-analyses and trial sequential analyses

Objective: To investigate the effects of fever therapy compared with no fever therapy in a wide population of febrile adults. Design: Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Data sources: CENTRAL, BIOSIS, CINAHL, MEDLINE, Embase, LILACS, Scopus, and Web of Science Core Collection, searched from their inception to 2 July 2021. Eligibility cr

Prognostic implications of structural heart disease and premature ventricular contractions in recovery of exercise

Premature ventricular contractions (PVCs) during recovery of exercise stress testing are associated with increased cardiovascular mortality, but the cause remains unknown. We aimed to evaluate the association of PVCs during recovery with echocardiographic abnormalities, and their combined prognostic performance. Echocardiographic abnormalities [reduced left ventricular (LV) ejection fraction, valv

Outcomes and interventions in patients transported to hospital with ongoing CPR after out-of-hospital cardiac arrest - An observational study

INTRODUCTION: The main objective was to present characteristics and outcome of patients without sustained field return of spontaneous circulation (ROSC) transported to hospital with ongoing cardiopulmonary resuscitation (CPR). Our secondary objectives were to investigate hospital-based interventions and the performance of the universal Termination of Resuscitation-rule (uTOR).METHODS: In this retr

The modified Medical Research Council scale misclassifies exertional breathlessness among people referred for exercise testing

BACKGROUND: Exertional breathlessness is a major symptom in cardiorespiratory disease and is often assessed using the modified Medical Research Council (mMRC) questionnaire. The mMRC might underestimate exertional breathlessness in people with impaired exercise capacity who have reduced their physical activity to avoid the symptom. We aimed to evaluate the ability of mMRC to detect abnormally high

Organisational Measures and Strategies for a Healthy and Sustainable Extended Working Life and Employability : A Deductive Content Analysis with Data Including Employees, First Line Managers, Trade Union Representatives and HR-Practitioners

Due to the global demographic change many more people will need to work until anolder age, and organisations and enterprises need to implement measures to facilitate an extendedworking life. The aim of this study was to investigate organisational measures and suggestionsto promote and make improvements for a healthy and sustainable working life for all ages in anextended working life. This is a qu

RadClim BSR – Towards a High-resolution Radar-based Precipitation Climatology for the Baltic Sea Region

Archived radar data has various applications, though it is often underutilised. Nevertheless, this information has the possibility to aid in the development of accurate and relevant climate adaptation tools, inform climate-resilient urban development strategies, and numerous other personal and societal applications. Our work in the RadClim Baltic Sea Region (BSR) project established the potential

Quality of life for patients with advanced gastrointestinal cancer randomised to early specialised home-based palliative care: the ALLAN trial

BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.MethodsWe randomly assigned ambulatory patients w

A short delay from out of hospital cardiac arrest to call for ambulance increases survival

Aim To describe the relative impact on survival of the delay from estimated time of collapse to call for an ambulance among patients who suffer from a bystander witnessed out of hospital cardiac arrest of a cardiac aetiology. Methods A majority of all ambulance organizations in Sweden (covering 85% of Sweden inhabitants) participate in a National survey of out of hospital cardiac arrest. Results I

Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.

The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, b