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Fragment screening using WAC towards new SMARCA4 inhibitors

Syftet med avhandlingen var att undersöka och utvärdera bindningen av molekyler mot ett målprotein som är involverad i tillväxten av cancerceller. Undersökning genomfördes på Red Glead Discovery med WAC (weak affinity chromotography) som är en kromatografisk separationsmetod, där molekyler med olika vikt pumpas genom olika kolonner och retentionstiden för molekylerna i kolonnen detekteras. MolekylThe drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been impleme

Biogeografisk uppföljning 2020 av dagfjärilar inom habitatdirektivet

Rapporten sammanfattar fjärilsinventeringar utförda 2020 inom Biogeografisk uppföljning som drivs av Naturvårdsverket. I fjällområdet kunde totalt 49 ytor inventeras. Sammanlagt noterades 151 högnordiska blåvingar på 22 inventerade ytor, 53 dvärgpärlemorfjärilar på 25 ytor och minst 1 fjällsilversmygare noterades på 3 inventerade ytor. Svartfläckig blåvinge observerades på 15 av 50 inventerade lok

Biogeografisk uppföljning 2022 av dagfjärilar inom habitatdirektivet

Rapporten sammanfattar fjärilsinventeringar utförda 2022 inom Biogeografisk uppföljning som drivs av Naturvårdsverket. I fjällområdet kunde totalt 35 ytor inventeras. Sammanlagt noterades 38 högnordiska blåvingar på 12 av 16 inventerade ytor, 34 dvärgpärlemorfjärilar på 14 av 17 ytor och 3 fjällsilversmygare noterades på 2 av 3 inventerade ytor. Svartfläckig blåvinge observerades på 23 av 56 inven

First comprehensive tool for screening pain in Parkinson's disease : the King's Parkinson's Disease Pain Questionnaire

Background and purpose: Pain is highly prevalent in Parkinson's disease (PD), impacting patients’ ability, mood and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-ba

The geomagnetic field intensity in New Zealand : Palaeointensities from Holocene lava flows of the Tongariro Volcanic Centre

Very few absolute palaeointensity data exist from Holocene-aged rocks in New Zealand. Here we present a new suite of high-quality palaeointensities, supported by detailed rock magnetic investigations. Samples from 23 sites representing 10 distinct eruptive units of the Tongariro Volcanic Centre, Taupo Volcanic Zone, New Zealand, were studied. Both traditional double heating and microwave palaeoint

Sleep apnea prevalence and severity after coronary revascularization versus no intervention : a systematic review & meta-analysis

Purpose: Obstructive sleep apnea (OSA) is a common disease in patients with coronary artery disease (CAD). Approximately 40–80% of cardiovascular disease patients have obstructive sleep apnea. The manifestation of it can vary significantly in different types of CAD patients. This systematic review and meta-analysis investigate the prevalence and severity of OSA in patients with acute coronary synd

Modeling catalytic promiscuity in the alkaline phosphatase superfamily

In recent years, it has become increasingly clear that promiscuity plays a key role in the evolution of new enzyme function. This finding has helped to elucidate fundamental aspects of molecular evolution. While there has been extensive experimental work on enzyme promiscuity, computational modeling of the chemical details of such promiscuity has traditionally fallen behind the advances in experim

Nonthermal GSM RF and ELF EMF effects upon rat BBB permeability

Since the late 1980s, our group has examined the effects of radiofrequency electromagnetic fields (RF-EMF), including pulse-modulated waves of the type emitted by mobile phones, upon the blood-brain barrier. In more than 2,000 rats, we have repeatedly demonstrated a passage of the rats' own albumin from the blood through the brain capillaries into the surrounding brain parenchyma at SAR values dow

The Upright Tiara of the Persian King

This paper examines a piece of headgear, usually referred to in modern literature asa Phrygian or Persian cap, but variously described as tiara, kurbasia or kidaris/kitaris in the ancient sources. According to Greek texts only the Persian king had theright to wear the headgear in an upright position, usually referred to as tiara orthé.The cap was part of the so-called Median riding dress, and was This paper examines a piece ofheadgear, usually referred to in modern literature as a Phrygian or Persian cap, but variously described astiara, kurbasiaor kidaris/kitarisin the ancient sources. According to Greek texts only the Persian king had the right to wear the headgearin an upright position, usually referred to as tiara orthé. The cap was part of the so-called Median riding dress, and was wo

Modeling National Interdependent Critical Infrastructures : Application and Discussion for the Swedish Power and Internet Backbone

Critical Infrastructures (CIs) have a vital role in the functioning and development of our modern societies. To accurately understand the potential consequences of critical infrastructure disruptions, dependencies and potential cascading effects between CIs have to be considered in risk governance. As a step towards creating a system-of-systems model of Sweden’s national technical CIs, this paper

When Not Following Procedures Is a Safer Way: A Study on Selective Intentional Non-Compliance

This study investigates the concept of Selective Intentional Non-Compliance (SINC) in aviation. Deliberate, context-driven deviations from procedures motivated by safety in response to dynamic operational conditions. Based on a survey of 39 European commercial pilots, we analysed the prevalence, motivations, and perceived outcomes of procedural deviations. Nearly 43% reported deviating from s

Mven05 schema 2015 styrmedel for forebyggande miljoskydd

Styrmedel för förebyggande miljöskydd 2015 Preliminärt schema Alla lektioner komma att hållas i Internationella miljöinstitutets (IIIEE) lokaler, för karta till IIIEE se www.iiiee.lu.se. Lokalschema delas ut vid kursintroduktionen. Datum och tid, lokal Aktivitet Lärare Läsning Vecka 4 Miljöpolitik och Styrmedel / Ekonomiska styrmedel / Introduktion individuellt arbete 19 Jan 9-12 Rum 201, IIIEE Ku

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven05_schema_2015_styrmedel_for_forebyggande_miljoskydd.pdf - 2025-10-17

2017 03 03 iasp internship scheme 2017-2018

Internship positions 2017–2018 General information: IASP, located at the Technology Park of Andalusia (Spain), offers two 11 month internships from 3rd July 2017 to 31st May 2018, within the Communication & Events and Projects & Services working areas respectively. This document contains all the relevant information and conditions related to this internship programme. IASP is an international non-

https://www.psy.lu.se/sites/psy.lu.se/files/2017_03_03_iasp_internship_scheme_2017-2018.pdf - 2025-10-17

Agenda2030 FAQ 20210429

Published 24 March, updated 26 March, 20 April 2021 and 29 April 2021 Call for applications for university-wide funding – Interdisciplinary projects focusing on Agenda 2030 and sustainable development. Questions and answers. Part I. Frequently asked questions on the call.  Agenda 2030 has a wide scope. Do you have any priorities? The call will not make any priorities within Agenda 2030. The broad

https://www.staff.lu.se/sites/staff.lu.se/files/2021-04/Agenda2030_FAQ_20210429.pdf - 2025-10-17

Commercialising the Countryside

Forskningsprojekt inom Samhällsgeografi Projekttitel: LANDSBYGDENS KOMMERSIALISERING GENOM FRITIDSANLÄGGNINGAR. Ekonomiska möjligheter och hållbar utvecklingPeriod: 2008-2012Kontaktperson: Erik Jönsson, Guy Baeten BeskrivningProjektet, som finansierades av FORMAS, syftade till att få en fördjupad förståelse över de samtidigt sociala, ekonomiska och miljömässiga förändringar i rurala landskap som k

https://www.keg.lu.se/forskning/forskningsprojekt/avslutade-forskningsprojekt/commercialising-countryside - 2025-10-17

Ulrika Andersson

Professor Kontaktinformation E-post: ulrika [dot] andersson [at] jur [dot] lu [dot] se Telefon: +46 46 222 11 14Organisation Juridiska institutionen Rumsnummer: 502 Hämtställe: 56 WebbplatsUlrika Anderssons profil i Lunds universitets forskningsportalAndra roller Forskningskoordinator Rätt och utsatthet Skyddsombud Juridiska institutionen Docent Juridiska institutionen Forskare Mänskliga rättighet

https://www.jur.lu.se/ulrika-andersson - 2025-10-17

Richard Croneberg

Biträdande universitetslektor Kontaktinformation E-post: richard [dot] croneberg [at] jur [dot] lu [dot] se Telefon: +46 46 222 11 09Organisation Juridiska institutionen Rumsnummer: 431 Hämtställe: 56 WebbplatsRichard Cronebergs profil i Lunds universitets forskningsportalAndra roller Forskare Lunds skatteakademi Forskare Offentlig rätt Publikationer Visar av publikationer. Sorterade efter år och

https://www.jur.lu.se/richard-croneberg - 2025-10-17