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Background: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of neutralizing antibodies is therefore of primary importance, but is hampered by the fact that we do not know which assay(s) can provide measures of protective immu
Abstract in UndeterminedThis paper addresses the failure of activation programmes to achieve a rapid return to work when they are directed towards the long-term ill. The empirical basis for the paper is an analysis of the outcomes for 691 individuals in Sweden chosen for a re-activation policy programme to shorten their sick leave and increase their chances of returning to work. The outcome at the
The ambition to be recognized as a 'World City' or 'Global City' is rapidly increasing not the least among cities in the global south such as Hyderabad in India and Johannesburg in South Africa. While such a status seems promising for attracting foreign capital and for expanding the economic potential of urban areas, it may have adverse impacts on the hinterland and contribute to growing urban ine
Background Autologous haematopoietic stem cell transplantation (HSCT) is a viable option for treatment of aggressive multiple sclerosis (MS). No randomised controlled trial has been performed, and thus, experiences from systematic and sustained follow-up of treated patients constitute important information about safety and efficacy. In this observational study, we describe the characteristics and
Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely
Objective:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. Methods:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (M
The paper reports a study involving the use of Halomonas boliviensis, a moderate halophile, for co-production of compatible solute ectoine and biopolyester poly(3-hydroxybutyrate) (PHB) in a process comprising two fed-batch cultures. Initial investigations on the growth of the organism in a medium with varying NaCl concentrations showed the highest level of intracellular accumulation of ectoine (0
In 1997 the Ugandan government introduced a reform program with the ambition to implement universal primary education. The abolition of tuition fees would ideally guarantee access to the public service delivery system as far as primary education is concerned and help to integrate underprivileged groups with the rest of the diverse society. The launch of universal primary education in Uganda implie
South East Asia, and Thailand in particular, are experiencing rapid population ageing. In Thailand older people are increasing in both proportion of the population and absolute number. Adaptations are needed to support this ageing population and to prevent poverty in old age. Since 2009 Thailand has had a minimum universal social pension, the Old Age Allowance (OAA) for all citizens aged 60 and ov
Issue of study: The plastic injection moulding industry has become highly competitive in terms of lead times and pricing, following an increase in low-cost manufacturing from Asia, as a part of the full supply chain. To remain competitive, mould tool manufacturers are looking to complement new tool manufacturing with local after-sales services in countries where their mould tools are being used. U
In digital integrated circuits, memories are often a limiter for main performance, power and area. Over the past decade, integrated memories have gained dominance in terms of area and power cost. In applications like machine learning or image processing the area share can be above 80% consuming more than 50% of the total power budget. On-chip memories in CMOS technologies can be categorized as sta
The petrochemicals industry (mainly plastics and fertilizer production) is expanding, despite increasing attention to the environmental impact of petrochemicals. In our paper, we explore the role public finance plays in the petrochemicals industry. We do so by mapping the public and private financial flows into large-scale petrochemical projects for the decade 2010-20 and discuss the role of publi
A survey of nuclear structure results obtained along α-decay chains stemming from isotopes of element 114, Fl, and element 115, Mc, is presented. Measures taken to ensure a reliable hand-over of nuclear spectroscopy output to nuclear structure theory are outlined. Possible links between decay chains starting from element 117, Ts, and element 115, Mc, are commented on. The experiments were conducte
In this paper, we present a new account of teleological reasons, i.e. reasons to perform a particular action because of the outcomes it promotes. Our account gives the desired verdict in a number of difficult cases, including cases of overdetermination and non-threshold cases like Parfit’s famous Drops of water. The key to our account is to look more closely at the metaphysics of causation. Accord
We report on the development of a method based on recombinant yeast Saccharomyces cerevisiae to produce nonivamide, a capsaicinoid and potent agonist of the pain receptor TRPV1. Nonivamide was produced in a two-step batch process where yeast was i) grown aerobically on glucose and ii) used to produce nonivamide from vanillin and non-anoic acid by bioconversion. The yeast was engineered to express
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic 3D cellular architecture and organization. Current technologies suffer from a lack of design flexibility and complex prototyping, preventing their broad adoption by the scientific community. To make 3D cell culture more available and adaptable we here describe the use of the fused deposition modeli
Leaf functional traits are key indicators of plant functions useful for inferring complex plant processes, including their responses to environmental changes. Vegetation indices (VIs) composed of a few reflectance wavelengths hold the advantages of being relatively simple and effective and have been widely used within remote sensing to estimate leaf traits. However, the difference between the refl
