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The emerging notion of hematopoietic stem and progenitor cells (HSPCs) as a low-primed cloud without sharply demarcated gene expression programs raises the question on how cellular-fate options emerge and at which stem-like stage lineage priming is initiated. Here, we investigate single-cell chromatin accessibility of Lineage-, cKit+, and Sca1+ (LSK) HSPCs spanning the early differentiation landsc
Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have
OBJECTIVE: To examine how intersections of multiple sociodemographic variables explain the individual heterogeneity in risk of being diagnosed with any of following chronic rheumatic diseases (CRDs): osteoarthritis (OA), gout, rheumatoid arthritis (RA), or spondyloarthritis (SpA).METHODS: We identified people aged 40-65 years residing in Skåne, Sweden, by 31st December 2013 and having done so from
Alzheimer’s disease affects millions of lives worldwide. This terminal disease is characterized by the formation of amyloid aggregates, so-called amyloid oligomers. These oligomers are composed of β-sheet structures, which are believed to be neurotoxic. However, the actual secondary structure that contributes most to neurotoxicity remains unknown. This lack of knowledge is due to the challenging n
The performance of a new type of X-band Weather Radar (WR) for Sweden during a pilot run is studied. Compared to the conventional C-band WRs, the X-band WR covers a smaller area but with a higher spatiotemporal resolution, making it suitable for urban hydrological applications. Rainfall estimations from different elevation angles of the radar (levels) are compared at one-minute and single-event ti
This study presents an example of when the government introduced a regulation that did not coincide research, professional ethics, responsibility or commitments, and led to a conflict between professionals and rulers.In the Swedish statutes regulating opioid maintenance treatment (OMT), a unique definition of the term opiate-dependency, the opiate rule, was introduced in 2010—restricting the targe
Revival of Industrial Hemp: A systematic analysis of the current global industry to determine limitations and identify future potentials within the concept of sustainability Revised Version December 9th, 2005 Author: Erin Michelle Young, LUMES erin-michelle.young.891@student.lu.se Thesis submitted in partial fulfillment of the requirements of the Master’s Degree of International Environmental Scie
https://www.lumes.lu.se/sites/lumes.lu.se/files/erin_young.pdf - 2026-06-28
Brevmall Konstnär l iga fakulteten i Malmö Faststäl ld i Konstnärl iga fakultetsnämnden 2014-09-25 Föreskrifter om handledning och andra resurser för forskarutbildning 1. Handledning och andra resurser Regelverket • HF: 7 kap 34§ ”Till utbildning på forskarnivå får endast så många doktorander antas som kan erbjudas handledning och godtagbara studievillkor i övrigt och som har studiefinansiering en
https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/handledning_och_andra_resurser_2.pdf - 2026-06-28
Microsoft PowerPoint - Olika sätt att arbeta med användarundersökningar EBSCO SNUG EBSCO SNUG användardagar 2020 Eva Sejmyr Linköpings universitetsbibliotek Olika sätt att jobba med användarundersökningar Vem är jag: För några år sedan bestämdes det att biblioteket behövde en samordnare av den allt större systemtekniska infrastrukturen. – och det blev jag. Övergripande ansvar för i stort sett a
https://www.ub.lu.se/sites/ub.lu.se/files/eva_sejmyr_liub_olika_satt_att_arbeta_med_anvandarundersokningar.pdf - 2026-06-28
Treatment with warfarin in combination with clopidogrel has been shown to reduce the incidence of major bleeding as compared to triple antithrombotic therapy (TT; warfarin, clopidogrel and aspirin). However, there are uncertainties regarding the risk for thrombosis since poor-responsiveness to clopidogrel is common. Ticagrelor is a more potent platelet inhibitor, but data supporting concurrent use
Under metoo-hösten år 2017 publicerade pressen namn på flera kända män som blivit anklagade för olika typer av sexualbrott. En av dessa män var stjärnjournalisten Fredrik Virtanen som från en dag till en annan pekades ut som våldtäktsman i Sveriges största tidningar. Pressen publicerade namn och detaljer om anklagelserna, trots att anklagelserna grundades på bristfällig bevisning. Hur kunde detta
Det har skrivits mycket om Karen Blixen genom åren, både av danska, svenska och engelsktalande författare. Hennes liv och författarskap har fascinerat många, så även mig. I min uppsats kommer jag att ta fasta på några frågeställningar med anknytning till Den afrikanske farm. Ett syfte är att belysa genreproblematiken, och svårigheten att sätta in Den afrikanske farm i något av de vedertagna genre
AIMS: To describe the level of physical activity 6 months after an out-of-hospital cardiac arrest (OHCA) and to explore potential risk factors of a low level of physical activity.METHODS: Post-hoc analyses of the international multicentre Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac arrest (TTM2) trial. At 6 months, survivors at 61 sites in Europe, Australia and
The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African cou
BACKGROUND: Melanoma is a highly heterogeneous disease, and a deeper molecular classification is essential for improving patient stratification and treatment approaches. Here, we describe the histopathology-driven proteogenomic landscape of 142 treatment-naïve metastatic melanoma samples to uncover molecular subtypes and clinically relevant biomarkers.METHODS: We performed an integrative proteogen
BACKGROUND: Melanoma, the deadliest form of skin cancer, exhibits resistance to conventional therapies, particularly in advanced and metastatic stages. Mitochondrial pathways, including oxidative phosphorylation and mitochondrial translation, have emerged as critical drivers of melanoma progression and therapy resistance. This study investigates the mitochondrial proteome in melanoma to uncover no
The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb
Background: Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from th
Objectives Better understanding of societal factors associated with COVID-19 vaccination can have important implications for public health policy to increase uptake.Methods This study investigated sociodemographic determinants of COVID-19 vaccine uptake with ≥2 doses vs 0 doses, and ≥3 doses vs 2 doses, among adults (≥18 years) in a general population from Sweden followed from 27 December 2020 (n=
Integration of fiber modification step with a modern pulp mill is a resource efficient way to produce functional fibers. Motivated by the need to integrate polymer adsorption with the current pulping system, anion-specific effects in carboxymethylcellulose (CMC) adsorption have been studied. The QCM-D adsorption experiments revealed that CMC adsorption to the cellulose model surface is prone to an
