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Fragmentomic analysis of circulating tumor DNA-targeted cancer panels

BACKGROUND: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to inf

Genomic Characteristics Related to Histology-based Immune Features in Breast Cancer

The immune cell component of the tumor microenvironment is an important modulator of tumor progression. In patients with breast cancer, tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLS) represent core aspects of anti-tumor immunity, both increasingly recognized for clinical relevance. In this study, we evaluated immune-related histology features using whole slide H&E

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes. a p

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children RESEARCH ARTICLE Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children Ezio Bonifacio1, Andreas Beyerlein2,3,4, Markus Hippich2,3,4, Christiane Winkler2,3,4, Kendra Vehik5, Michael N. Weedon6, Mic

https://www.teddy.lu.se/sites/teddy.lu.se/files/genetic_scores_to_stratify_risk_of_developing_multiple_islet_autoantibodies_and_type_1_diabetes._a_prospective_study_in_children.pdf - 2026-05-18