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Objectives: We aimed to determine the lifetime genetic risk for anterior cruciate ligament (ACL) rupture. Methods: We used a twin study approach, linking the Swedish Twin Register with national healthcare data to form a 30 year, population wide, longitudinal twin cohort. We studied ACL rupture in this cohort of 88 414 identical and fraternal twin pairs, aged ≥17 years, to determine the familial ri
Background: Global transcriptional profiling of individual cells represents a powerful approach to systematically survey contributions from cell-specific molecular phenotypes to human disease states but requires tissue-specific protocols. Here we sought to comprehensively evaluate protocols for single cell isolation and transcriptional profiling from heart tissue, focusing particularly on frozen t
Background and purpose: Few studies on magnetic resonance imaging (MRI) only head and neck radiation treatment planning exist, and none using a generally available software. The aim of this study was to evaluate the accuracy of absorbed dose for head and neck synthetic computed tomography data (sCT) generated by a commercial convolutional neural network-based algorithm. Materials and methods: For
Background: Chronic pain (CP) has serious medical and social consequences and leads to economic burden that threatens the sustainability of healthcare services. Thus, optimized management of pain tools to support CP patients in adjusting to their condition and improving their quality of life is timely. Although acceptance and commitment therapy (ACT) is considered an evidence-based psychological a
The transition to a resource efficient economy that makes effective use of raw materials and energy is a multi-level dynamic process requiring a wide systems perspective. To operationalize this transition in a holistic manner, the concept of Circular Economy (CE) has been championed by major economies around the world. The idea with CE is to strive towards maximizing the utilization of products, c
Background: New emerging evidence has demonstrated the need for effective interventions to help people living with an acquired brain injury (ABI). Evidence on cost-effectiveness, which can help inform use of limited resources, is scarce in this area and therefore the purpose of this systematic review is to critically appraise and consolidate the current evidence on economic evaluations of ABI reha
Improving urban liveability and prosperity is commonly set as a priority in urban development plans and policy around the world. Several annual reports produced by international consulting firms, media, and global agencies rank the liveability of cities based on a set of indicators, to represent the quality of life in these cities. The higher is the ranking, the more liveable is the city. In this
Societal safety and sustainability are key challenges in our complex and dynamic world, causing growth in interest of applying the concept of resilience in broader societal contexts. This chapter presents a concept of societal resilience that builds on established theory of Resilience Engineering and operationalises the concept by presenting its purpose, required functions and a way to identify an
Extending the lifetime of products enables material resource savings and provides an effective resource efficiency strategy within a circular economy paradigm. Although consumer demand for longer lasting products that can be easily repaired has been on the rise, it is not certain that consumers are fully able to identify such products and willing to pay a premium for them. France introduced a mand
Dense urban morphologies further amplify extreme climate events due to the urban heat island phenomenon, rendering cities more vulnerable to extreme climate events. Here we develop a modelling framework using multi-scale climate and energy system models to assess the compound impact of future climate variations and urban densification on renewable energy integration for 18 European cities. We obse
The aim of this project was to determine the consequences of the large-scale introduction of wood-based biofuels in the road transport sector. Therefore a model has been developed to project the demand for wood in Sweden in the period from 2007 to 2050. The wood-using sectors that were taken into account are: the sawmill industry; the paper and pulp industry, which was split in three: integrated c
Horisonter med subfossila stubbar och rötter av tall (Pinus sylvestris) är vanliga i stratigra-fier från torvmarker i norra Europa. Dessa är tydliga indikationer på att det under holocen funnits perioder med tillräckligt gynnsamma förhållanden för tallar att växa på mossar. Tall kan endast växa på mossar när ytan är tillräckligt torr, och därför är rester av tallar på mossar goda indikationer på eHorizons rich in subfossil stumps and roots of Scots pine (Pinus sylvestris) are frequently found in stratigraphies of northern European peatlands, providing clear evidence of Holocene periods with favourable conditions for bog-pine growth. The pines could only grow when bog-surface wetness was sufficiently low, and the presence of their remains is therefore a good indicator of past climatic condi
The purpose of this study is to conduct the Life Cycle Assessment of IKEA’s two Sofa products and provide recommendations for reducing the overall carbon footprints. Different phases of supply chains are included in the scope of this study, i.e., selection of raw materials, their acquisition, production phase, and transportation of final product to market regions. The benefit of the study is that
The Waste Electrical and Electronic Equipment Directive of the European Commission places the responsibility on producers to finance collection and treatment of waste deposited at collection facilities after 13 August 2005, on a collective or individual basis. For "historic" waste, put on the market before this date, producers are responsible for a proportion of their respective share of
In this paper, the moral duty towards asylum seekers and refugees in the EU is highlighted, from the perspectives of Universalism and Communitariarism. Due to different levels of safety and conditions related to being granted asylum in EU member states, the attractiveness of these states for asylum seekers and refugees to seek protection differ substantially. The implementation of the Dublin II Co
Over recent decades, management of people with hemophilia (PwH) has been greatly improved by scientific advances that have resulted in a rich and varied therapeutic landscape. Nevertheless, treatment limitations continue to drive innovation, and emerging options have the potential to realize further improvement. We advocate four general principles to optimize benefits from innovation: individualiz
OBJECTIVES: Analysis of the long-term risks of ischaemic stroke and cerebral bleeding in patients with atrial fibrillation after mitral valve surgery and concomitant Cox-maze IV procedure. METHODS: In total, 397 patients with symptomatic degenerative mitral valve insuffciency and atrial fibrillation, underwent mitral valve surgery and Cox-maze IV in Sweden between 2009 and 2017. In this retrospect
It is well known that Lithium-ion batteries in thermal runaway can emit gases with high hydrogen concentrations which, in case of delayed ignition, can cause a gas explosion. Aerosol suppression agents are sometimes used to suppress fires and/or prevent ignition of released gases in such situations. The agent has been studied for suppression of fires (diffusion flames), but less is known about the
