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Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke.

Apolipoprotein E (ApoE), a cholesterol transporter and an immunomodulator, is brain protective after experimental stroke and implicated in brain repair. Here, we study the involvement of ApoE in the restoration of brain function after experimental stroke, by using animal housing conditions that differentially improve recovery after occlusion of the middle cerebral artery occlusion (MCAO). We found

Space, Culture and the Youth in Iran: Observing Norm Creation Processes at the Artists' House

This book uses the case of the Artists' House, a cultural center in Tehran, to place the socio-political implications of Iran's social and cultural transformation in a local-global context. The author examines the bipolar dimension of openness to change versus conservation and the role of these values in Iranian society generally as well as in the context of everyday life in Tehran. The text addre

Sources of parent-offspring resemblance for major depression in a national Swedish extended adoption study

Importance: Twin studies have assessed sibling resemblance for major depression (MD) but cannot address sources of resemblance across generations. Objective: To clarify the relative importance of genetic and rearing effects on the parent-offspring resemblance for MD. Design: This Swedish population register-based study examined parents and children from the following 5 family types: intact (2 041

Compromise and learning when negotiating sustainabilities : The brownfield development of hammarby sjöstad, stockholm

This article examines the environmental management of Stockholm's large brownfield development Hammarby Sjöstad through the concept of negotiating sustainabilities. An Environmental Programme injected exceptional aims into an ongoing, ordinary planning process involving developers, consultants, contractors and other stakeholders. In parallel, a project team was established and given the task of re

Visualising household energy use in the interest of developing sustainable energy systems

In times of climate change political goals concern a reduction in total energy consumption and to use energy more efficiently. To achieve this, users need to transform their behaviour and start reflecting on their energy use. This paper discusses three different methods for visualising energy use, namely information tools, keeping time-diaries and using the 'Power-Aware Cord'. Each method has its

Phase 3 assessment of the automated bone scan index as a prognostic imaging biomarker of overall survival in men with metastatic castration-resistant prostate cancer a secondary analysis of a randomized clinical trial

IMPORTANCE Prostate cancer commonly metastasizes to bone, and bone metastases are associated with pathologic fractures, pain, and reduced survival. Bone disease is routinely visualized using the technetium Tc 99m(99mTc) bone scan; however, the standard interpretation of bone scan data relies on subjective manual assessment of counting metastatic lesion numbers. There is an unmet need for an object

A preanalytic validation study of automated bone scan index : Effect on accuracy and reproducibility due to the procedural variabilities in bone scan image acquisition

The effect of the procedural variability in image acquisition on the quantitative assessment of bone scan is unknown. Here, we have developed and performed preanalytical studies to assess the impact of the variability in scanning speed and in vendor-specific γ-camera on reproducibility and accuracy of the automated bone scan index (BSI). Methods: Two separate preanalytical studies were performed:

Sedentary Time and Physical Activity Surveillance Through Accelerometer Pooling in Four European Countries

Objective: The objective of this study was to pool, harmonise and re-analyse national accelerometer data from adults in four European countries in order to describe population levels of sedentary time and physical inactivity. Methods: Five cross-sectional studies were included from England, Portugal, Norway and Sweden. ActiGraph accelerometer count data were centrally processed using the same algo

Unions and the rights of migrants in the long run

We use historical data on union density and new historical data on policies toward migrants to study the long-run relationship between the strength of trade unions and the social and economic rights of migrants in the Global North. In countries with strong trade unions, there was, for a long time, a widening distance between the rights of migrants and the rights of citizens, probably because the r

Removal of pharmaceuticals with ozone at 10 Swedish wastewater treatment plants

Pilot-scale tests were run with ozonation for reduction of 24 pharmaceuticals at 10 full-scale wastewater treatment plants in southern Sweden. Reduction was evaluated based on doses of 3, 5 and 7 g O3/m3 at all plants. The reduction of pharmaceuticals reached on average 65% at 3 g O3/m3, 78% at 5 g O3/m3 and 88% for 7 g O3/m3 in terms of total concentration of pharmaceuticals. Specific ozone dose

Clinically Assessed Knee Joint Laxity as a Predictor for Reconstruction After an Anterior Cruciate Ligament Injury: A Prospective Study of 100 Patients Treated With Activity Modification and Rehabilitation.

BACKGROUND: The association of early knee joint laxity with the need for later reconstruction of the anterior cruciate ligament has not been extensively studied. HYPOTHESIS: The grade of knee laxity can be used as an early predictor of the need for later reconstruction. STUDY DESIGN: Cohort study (prognosis); Level of evidence, 2. METHODS: One hundred consecutive patients with an acute arthroscopi

Sociala normer och regelefterlevnad : Trafiksäkerhetsfrågor ur ett rättssociologiskt perspektiv

The thesis aims to: (a) broaden the knowledge base that makes up the foundation for decisions with regard to how traffic law enforcement is best outlined, as well as increasing the understanding of how the shaping of different public instruments of control affects the chances of success; and (b) contribute to the development of theory and methodology within sociology of law. The relationship betwe

Radial head and neck fractures

Popular Abstract in Swedish Strålbensfrakturer i armbågsleden I denna avhandling har jag försökt kartlägga hur det går för individer som drabbats av ett benbrott i anslutning till armbågen. I underarmen finns två ben, strålbenet och armbågsbenet. Strålbenets övre del ledar dels mot överarmsbenet men också mot armbågsbenet. När en person ramlar med utsträckt arm finns det risk att det uppstår ett All elbow fractures between 1969 – 1979 (n=2965) registered at the radiographic archives at the Malmö University Hospital, where all radiographs are saved since a century, were evaluated. Fractures of the radial head and neck were classified according to the by Broberg and Morrey modified Mason classification. A Mason type I fracture is a less than 2 mm displaced fracture of the radial head or nec

Formation of Pebble-Pile Planetesimals and the Interior Structure of Comets

Bildandet av planeter äger rum i skivor av gas, stoft och is runt nybildade stjärnor. Den här processen är inte helt förstådd men det första steget tros vara växten från mikrometer-stora stoftkorn till mm-cm-stora småstenar genom sammanväxande kollisioner. Vid de här storlekarna studsar stenarna eller går sönder snarare än fastnar i varandra när de kolliderar så tillväxten avstannar. Dessutom kännPlanets form in protoplanetary discs of gas, dust and ice around newborn stars. In the Solar System, not only planets are found as a result from the time of planet formation, but also remnant planetesimals in the form of asteroids, Kuiper belt objects and comets. Recent observations, e.g. by the space mission Rosetta, have found that comets are porous objects barely able to hold themselves togethe

Regulation of rod phototransduction machinery by ciliary neurotrophic factor

Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a potential treatment for retinal degenerative disorders. Here we report that the suppression of ERG responses is attributable to negative regulation of t

Pharmacometabolomic Profiling Of The General Population: Relation Of Active Metabolite Levels To Cardiovascular Risk Factor Control And Manifest Atherosclerosis

Introduction: The use of medications in the general population has increased over time. Information on active metabolite concentrations for common drugs in the general population is limited. Recent advances in metabolomic technologies have made high-throughput profiling of many active metabolites in large epidemiological cohorts increasingly feasible.Aim: 1. Prospective assessment of the proportio

ForMAX – a beamline for multiscale and multimodal structural characterization of hierarchical materials

The ForMAX beamline at the MAX IV Laboratory provides multiscale and multimodal structural characterization of hierarchical materials in the nanometre to millimetre range by combining small- and wide-angle X-ray scattering with full-field microtomography. The modular design of the beamline is optimized for easy switching between different experimental modalities. The beamline has a special focus o