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Background Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial signal of efficacy in BRCA-deficient ovarian cancers have been reported. We therefore assessed the efficacy, safety, and tolerability of olaparib alone in women with BRCA1 or BRCA2 mutations and advanced breast cancer. M

The rs738409 C > G single-nucleotide polymorphism in PNPLA3 leads to a missense mutation (I148M) which increases liver fat but does not cause insulin resistance. We hypothesised that patients with non-alcoholic fatty liver disease (NAFLD) due to the PNPLA3 variant ('PNPLA3 NAFLD'aEuro parts per thousand= PNPLA3-148MM) do not have adipose tissue (AT) inflammation in contrast with those with NAFLD d

The Mutual Reinforcement Between United Front Work and Cognitive Warfare: Implications for Countermeasures WEN-PING LIU LUND UNIVERSITY PSYCHOLOGICAL DEFENCE RESEARCH INSTITUTE | WORKING PAPER 2026:1 LUND UNIVERSITY PSYCHOLOGICAL DEFENCE RESEARCH INSTITUTE, WORKING PAPER 2026:1 1 The Mutual Reinforcement Between United Front Work and Cognitive Warfare: Implications for Countermeasures Dr. Wen-Ping

https://www.psychologicaldefence.lu.se/sites/psychologicaldefence.lu.se/files/2026-04/LU%20PDRI%20Working%20Paper%202026-1_United%20Front%20Work%20and%20Cognitive%20Warfare_final.pdf - 2026-05-28

Kursguide - Course Syllabus • • • Fastställande Kursplanen är fastställd av Ledningsgruppen för kandidatprogrammet i Equality and Diversity Management 2015-11-25 att gälla från och med 2016-01-01, vårterminen 2016. Allmänna uppgifter Kursen ingår i kandidatprogrammet för equality and diversity management och ges andra terminen. Undervisningsspråk: svenska Moment på engelska kan förekomma. Kursens

https://www.ses.lu.se/sites/ses.lu.se/files/kp_edmb22_151125.pdf - 2026-05-28

Microsoft Word - Behavioral platform report 20190213.docx Behavioral platform 1. Short description of the platform The in vivo platform that offers behavioral testing for rats and mice in separate rooms, as well as a facility to harvest the brain and other organs (called rat, mouse and termination below). The platform is located in an environment that is very close to state-of-the-art laboratory f

https://www.multipark.lu.se/sites/multipark.lu.se/files/behavioral_platform_report_2019.pdf - 2026-05-28

PII: 0006-8993(80)90692-7 Brain Research, 199 (1980) 307-333 0 Elsevier/North-Holland Biomedical Press 307 RElNNERVATION OF THE DENERVATED STRIATUM BY SUBSTANTlA NIGRA TRANSPLANTS : FUNCTIONAL CONSEQUENCES AS REVEALED BY PHARMACOLOGICAL AND SENSORIMOTOR TESTING A. BJORKLUND, S. B. DUNNETT, U. STENEVI, M. E. LEWIS* and S. D. IVERSEN Department of Histology, University of Lund, Lund (Sweden) and (S.

https://www.wnc.lu.se/sites/wnc.lu.se/files/bjorklund_et_al_brain_res_1980.pdf - 2026-05-28

Att förutsäga framtiden – modellering som ett verktyg för att förutsäga vattenkvantitet och vattenkvalitet Inom 100 år så kommer klimatet förändrats avsevärt om utsläpp av växthusgaser fortsätter i samma takt som idag. Detta kommer påverka temperatur, nederbörd vilka i sin tur påverkar flödet av vatten i Sverige. Ett avrinningsområde består av olika jordtyper, vegetation och topografi, vilka allClimate change will alter the hydrological cycle in the 21st century with implications for the water balance and water quality. As characteristics of the landscape may vary significantly between nearby locations, hydrological models need to be able to delineate responses attributed to specific landscape characteristics, to estimate their responses to altered climatic drivers. Small streams are the

We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case–control subset

The Baltic Sea is one of many aquatic ecosystems that show long-term declines in dissolved silicate (DSi) concentrations due to anthropogenic alteration of the biogeochemical Si cycle. Reductions in DSi in aquatic ecosystems have been coupled to hydrological regulation reducing inputs, but also with eutrophication, although the relative significance of both processes remains unknown for the observ

The aim of this thesis was to elucidate developments in epidemiology, clinical manifestations and complications in Chlamydia trachomatis (C.trachomatis) and Mycoplasma genitalium (M.genitalium) infection. In study I the frequencies of non-gonococcal salpingitis, gonococcal salpingitis and ectopic pregnancy (EP) were observed over a period of 28 years and correlated to the prevalence of Neisseria g

1. In a correlative study, we investigated the relative importance of fish predation, refuge availability and resource supply in determining the abundance and size distributions of the introduced and omnivorous signal crayfish (Pacifastacus leniusculus) in lakes and streams. Moreover, the biomass and food selection of predatory fish was estimated in each habitat type and stable isotopes of carbon

Background: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a key barrier to the development of a lower cost alternative, namely a discrete collection of immunohist

The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic facto

Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.

Recent global warming trends, particularly in the arctic regions and Himalayas are modifying forest structure and function, notably biogeographical changes in tree species distribution together with alteration in Net Primary Production (NPP), Leaf Area Index (LAI) and Carbon biomass. These alterations are most pronounced in mountain environments, carrying significant impacts on woody species which

Katalysatorer påskyndar en reaktion utan att själva förbrukas; denna mening känner nog många igen från sin skoltid. Andra har hört talas om katalysatorer som något de "har i bilen". Mycket riktigt är det främst i bilar där vi i våra vardagliga liv stöter på katalysatorer. Här används de för att omvandla de mycket giftiga gaserna kolmonoxid och kväveoxid till för människorna ofarligt kvävIn order to fully understand the underlying processes of catalysis, it is vital to combine measurements of the catalyst surface, where the reaction occurs, with measurements of the gas concentration close to the catalyst. We have developed a convenient setup, which uses a single laser system to visualise the gas surrounding a working catalyst in situ at realistic operating conditions. Planar Lase

Purpose: To assess the additional value of subtraction ictal single-photon emission computed tomography (SPECT) coregistered to MRI (SISCOM) for localization of the epileptogenic zone in patients with drug-resistant epilepsy scheduled for invasive video-EEG (VEEG) before epilepsy surgery by a descriptive study from clinical practice. Methods: Forty-nine consecutive epilepsy patients between Januar

Background: The aim of this study was to examine in elderly men a relationship between depressive symptoms, peripheral vascular disease and cerebral blood flow (CBF). Methods: Population-based cohort study started with an examination of 809 men at age 55, followed by the first (age 68ys) and second follow up (age 82ys). 128 survivors were examined at age 82 with Tc-99m-HMPAO-SPECT to estimate CBF,

Intermittent Parathyroid Hormone (PTH)((1-34)) has an established place in osteoporosis treatment, but also shows promising results in models of bone repair. Previous studies have been dominated by closed fracture models, where union is certain. One of the major clinical needs for anabolic therapies is the treatment of open and high energy fractures at risk of non-union. In the present study we th