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The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus

Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.

Engineering of pyranose 2-oxidase: Improvement for biofuel cell and food applications through semi-rational protein design

Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac

Studies on Neuropsychiatric Manifestations and Genetic Factors in Systemic Lupus Erythematosus

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. One of the hallmarks of the disease is a multitude of autoantibodies, indicating a breakdown in self tolerance. The corresponding antigens have been fou

Protein Engineering Allows for Mild Affinity-based Elution of Therapeutic Antibodies

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

Re-design of a Baby Carrier for Intuitive and Ergonomic Use

This master thesis was performed in collaboration with Najell AB with the purpose to improve their product, the SleepCarrier. The SleepCarrier can be used as a baby nest, a play mat and a soft carry cot. With the additional harness, the product can also be used as a baby carrier. The main focus of this project was to improve the user experience of the harness by focusing on ergonomics and intuitiv

Evaluation form examination projects

The Process (primarily evaluated by the Supervisor) Grade 1-5 1. Independence of the student 2. Ability to carry out the project (including practicals, e.g. field- or laboratory work) 3. The student´s ability to process and analyse data 4. The student´s ability to structure and write the report The Product (primarily evaluated by the Examiner) Grade 1-5 1. Organisation and quality of the written r

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2021-12/evaluation_form_examination_projects.pdf - 2026-05-23

Kp SMMV26 eng VT26 rev 250829

Syllabus SMMV26 Organising Sustainability This is a translation of the syllabus which was established in Swedish. STYR 2025/1953 Faculty of Social Sciences SMMV26, Organising Sustainability, 7.5 credits Organisera hållbarhet, 7,5 högskolepoäng Second Cycle / Avancerad nivå Details of approval The syllabus was approved by the board of the Department of Service Management and Service Studies on 2019

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2025-09/Kp_SMMV26_eng_VT26_rev_250829.pdf - 2026-05-23

Evolutionary and functional studies of protein H: a surface molecule of Streptococcus pyogenes

Popular Abstract in Swedish Protein H - ett bakteriellt ytprotein med förmåga att binda till olika proteiner hos människa Bakgrund I vårt dagliga liv omges vi av bakterier av många olika slag. Flertalet av dessa är normalt ofarliga och många utgör den så kallade normalfloran hos människa. En del bakterier kan under vissa förhållanden ge upphov till infektion och sjukdom, men för att åstadkomma d