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Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes

Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei

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Lägg till titel FÖRSÄTTSSIDA STYRDOKUMENT Kvalitetspolicy för Lunds universitet Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsst

https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Fakulteterna/Kvalitetsarbete/Kvalitetspolicy_f%C3%B6r_Lunds_universitet.pdf - 2026-05-21

Kvalitetspolicy för Lunds universitet. Beslut 2024-10-22.

Lägg till titel FÖRSÄTTSSIDA STYRDOKUMENT Kvalitetspolicy för Lunds universitet Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsst

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-11/Kvalitetspolicy%20fo%CC%88r%20Lunds%20universitet.pdf - 2026-05-20

Children Develop a Veil of Fairness

Previous research suggests that children develop an increasing concern with fairness over the course of development. Research with adults suggests that the concern with fairness has at least two distinct components: a desire to be fair but also a desire to signal to others that they are fair. We explore whether children’s developing concern with behaving fairly towards others may in part reflect a

Evaluating Off-the-shelf Hardware for Indoor Positioning

An indoor positioning system (IPS) is a system to locate objects in indoor environments using radio waves, magnetic fields, acoustic, optical and video signals or other sensory information with help of a number of known reference positions. Nowadays, indoor positioning based services are used in a wide variety of areas and indoor positioning is getting considerable attention from both research and

Två sidor av samma mynt? - Om den dubbla tillämpningen av armlängdsprincipen under artikel 7 och 9 i OECD:s modellavtal och vilka skillnader som finns däremellan.

Armlängdsprincipen kan betraktas som en av de mest centrala principerna inom den internationella beskattningsrätten. I OECD:s modellavtal, som ligger till grund för utformningen av bilaterala dubbelbeskattningsavtal, stadgas armlängdsprincipen i artikel 9, den regel som tillåter korrigering av ett företags vinst när interna transaktioner prissatts på ett sätt som inte är armlängdsmässigt. SamtidigThe ALP can be considered one of the most significant principles within international taxation law. It is regulated under article 9 of the OECD MTC, which acts as a model for developing new bilateral tax treaties. According to article 9, the profit of an enterprise may be adjusted if the enterprise has been involved in transactions with an associated enterprise on conditions that are not of an arm

Open-field behavioural alterations in liver-impaired and sham-operated rats after acute exposure to the antidepressant venlafaxine

Patients with chronic liver impairment often display symptoms of affective psychiatric nature where the choice for antidepressant treatment is rational. Since caution is recommended when these drugs are used in such patients, a dose reduction is usually performed. We have previously reported that a dose reduction to liver-impaired portacaval shunted rats has resulted in similar brain concentration

A novel broad-spectrum elastase-like serine protease from the predatory bacterium bdellovibrio bacteriovorus facilitates elucidation of site-specific IgA glycosylation pattern

The increased interest in predatory bacteria due to their ability to kill antibiotic resistant bacteria has also highlighted their inherent plethora of hydrolytic enzymes, and their potential as natural sources of novel therapeutic agents and biotechnological tools. Here, we have identified and characterized a novel protease from the predatory bacterium Bdellovibrio bacteriovorus: BspE (Bdellovibr

Brain-derived neurotrophic factor in cerebral ischemia: a quantitative study on surviving and newly formed neurons

Popular Abstract in Swedish Vår forskningsgrupp har tidigare påvisat kraftiga förändringar i genuttryck för neurotrofiner, en familj av tillväxtfaktorer för nervceller, och deras receptorer i kortikala och hippokampala nervceller vid olika hjärnskador. Det är till stora delar okänt vilken funktion neurotrofiner har efter hjärnskador, men neurotrofinsvaret skulle kunna vara en skyddande mekanism ocThis study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i.e., hippocampus and striatum, by combining specifi

Relationship of the Hormone-Sensitive Lipase-Mediated Modulation of Cholesterol Metabolism in Individual Compartments of the Testis to Serum Pituitary Hormone and Testosterone Concentrations in a Seasonal Breeder, the Mink (Mustela vison).

The role of cholesterol differs in the two compartments of the testis. In the interstitial tissue, cholesterol is necessary for the synthesis of testosterone, whereas in the seminiferous tubules, membrane cholesterol content in developing germ cells will influence the gametes' fertility. Here we evaluate the hormone-sensitive lipase (HSL) modulation of the cholesterol metabolism in each compartmen

Tissue response of radiation therapy assessed by electrical impedance spectroscopy (EIS) in subcutaneous tumours in rats.

Föreliggande undersökning syftar till att utvärdera möjligheten att använda bioimpedansspektrometri för att mäta tumör- och vävnadsrespons på strålterapi. Bioimpedansmätningar utförda med CythorLab ™ utrustade med en signalgenerator med en känd högutgångsimpedans och signalmätanordning som kan mäta spänningen som appliceras av generatorn. Styrenheten utlöser signalgeneratorn som genererar en MLS-sThe present investigation aims to evaluate the possibility of using bio-impedance spectrometry to measure tumour and tissue response to radiation therapy. Bio -impedance measurements performed with CythorLab™ equipped with a signal generator with a known high output impedance and signal measuring device able to measure the voltage applied by the generator. The control unit triggers the signal gene

Disputationer 2019

Robert SchwartzThe Court of Justice of the European Union and the European Court of Human Rights: Two Autonomous Human Rights (R)EvolutionsDatum för disputation: onsdagen den 6 november 2019Fakultetsopponent: Professor Jan Komárek, Köpenhamns universitetÄmne: EU-rättAbstractArticle 6 TEU requires the EU, an institution which has been in a constant state of evolution for over six decades, to accede

https://www.jur.lu.se/forskning/disputationer/disputationer-2019 - 2026-05-21

Intercomparison of C-14 Analysis of Carbonaceous Aerosols: Exercise 2009

Radiocarbon analysis of the carbonaceous aerosol allows an apportionment of fossil and non-fossil sources of airborne particulate matter (PM). A chemical separation of total carbon (TC) into its subfractions organic carbon (OC) and elemental carbon (EC) refines this powerful technique, as OC and EC originate from different sources and undergo different processes in the atmosphere. Although C-14 an