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Recombinant amelogenin - Strategies for purification and protein processing

Amelogenin is an extracellular matrix protein involved in formation of enamel during early tooth development. By interacting with the forming enamel crystallites amelogenin affects their growth, so that highly elongated hydroxyapatite crystals are formed. Early during the enamel formation amelogenin is proteolytically processed, which is essential for correct enamel formation. However, the exact m

Clearance of iohexol, 51Cr-EDTA and endogenous creatinine for determination of glomerular filtration rate in pigs with reduced renal function: a comparison between different clearance techniques

In order to simplify and/or improve determination of glomerular filtration rate (GFR) the clearances of iohexol, 51Cr-EDTA and endogenous creatinine were simultaneously determined with different techniques in 21 anesthetized landrace pigs. Their GFR had been reduced to about 1/3 or less of normal GFR. After an intravenous bolus of the GFR markers, their plasma concentration curves were followed fo

The Gastrin-ECL Cell Axis. Functional Aspects

Popular Abstract in Swedish Mag-tarmkanalen utgör kroppens största hormon-producerande organ. Många av de hormon-producerande cellernas funktion är ännu okänd och mycket lite är känt om den betydelse de kan ha vid olika sjukdomar i mag-tarmkanalen. I magsäckens syraproducerande del (fundus) finns 4 hormon-producerande celler, av vilka ECL cellen (65 %) och A-lika cellen (25 %) tillsammans utgör caThe ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. The first aim of the study was to prepare isolated ECL cells of high purity and to study and identify regul

Conformational and Dynamical Aspects of Conjugated Polymers and Oligomers of Interest for Photoluminescence

Popular Abstract in Swedish Lysande plast, finns det? Tanken är att att tunn plast-film skall kunna användas som ihoprullbara tunna TV- och datorskärmar, som lysdioder, som mottagare i solceller och som transistorer. Till vardags är förmodligen den vanligaste uppfattningen att plast är ett isolerande material som inte leder ström och som därför heller inte lyser. Faktum är att bara en del av plasTransient absorption laser spectroscopy and resonance Raman spectrscopy have been used to study conjugated polymers and oligomers. To extract more information the measurements have been compared to computer simulations and calculations. In order to obtain a better understanding of the role of conformational disorder in the photophysics of light-emitting, conjugated polymers the ultrafast transient

Altering the Point of You : Perspectives on Intersubjectivity and Metacognition

Popular Abstract in Swedish Syftet med denna avhandling var att undersöka olika aspekter på intersubjektivitet, metakognitiv utveckling och mellanmänsklig förståelse. Mer precist var syftet att undersöka hur några specifika teorier – mentaliseringsteorin, teorin om primär intersubjektivitet, samt interaktionsteorin – beskriver vilken roll intersubjektivitet har att spela i denna utveckling. De förThe aim of the thesis was to examine different aspects of the role of intersubjectivity in metacognitive development and in social understanding. More specifically, it investigates how different theoretical frameworks, such as mentalization theory, the theory of primary intersubjectivity, and interaction theory describe the developmental role of intersubjectivity. The suggestions these theories ma

Multiphysics modelling of PEM fuel cells - with reacting transport phenomena at micro and macroscales

Popular Abstract in Swedish Polymermembranbränsleceller (PEM) anses vara en mycket lovande teknik inom fordonsindustrin på grund av dess kompakthet i storlek, höga verkningsgrader samt låga arbetstryck och temperaturer. De senaste åren har tekniken varit fokus för en anseenlig mängd forskning. PEM-bränsleceller har den stora fördelen att energiomvandlingseffektiviteten har potential för att vara bThis thesis presents numerical simulations of reacting transport phenomena in polymer electrolyte membrane (PEM) fuel cells. Broadly, the presented work is subdivided into macro and microscale simulations. In macroscale simulations, a unit PEM fuel cell with interdigitated flow field configurations is simulated keeping in mind all the essential transport mechanisms, i.e., transport of species, ion

ONSHORE WINDMILL FOUNDATIONS - Evaluation of new proposals

Windmill structures must withstand very high horizontal loading giving an extremely large overturning moment on the foundation. These structures have very low stability loads in comparison to the overturning loads. The traditional way to solve the construction problem uses a shallow foundation with a massive concrete volume or a piled foundation to resist the extreme overturning moment. This work

Crafting Democracy : Civil Society in Post-Transition Honduras

Popular Abstract in Swedish Hur kan det civila samhället bidra till demokratisk utveckling? Inom demokratiseringsforskningen framställs ofta det civila samhället som ett centralt inslag i demokratiseringsprocessen. Vi saknar emellertid tydliga teoretiska föreställningar om vilken funktion det civila samhället fyller i en demokrati och om hur det civila samhällets organisationer kan bidra till demoCivil society is frequently singled out as one of the most important factors in the democratization process, but existing research is often imprecise with regard to civil society’s relation to democratic development. This study analyzes how, and under what circumstances, civil society can contribute to democratic development in newly established democracies. A conceptual framework is outlined that

Understanding therapeutic traditions in a multilevel framework - new methodological approaches

Background: The observation of differences in the way apparently similar patients are treated from one health care setting to another, i.e., practice variation, have been recognized in numerous studies. The variations across the health care settings have been shown to exist for different outcomes. However, any measurement of any system will reveal some form of variation and this normal inevitable

Transfer analysis of 210Po and 210Pb in the terrestrial environment

The transfer of 210Po and 210Pb between various compartments in the terrestrial environment has been analysed by using various published data. The average activity concentration of 210Po in soil is 61 ± 14 Bq.kg-1 d.w. with a median (50%) value of 44 Bq.kg-1 d.w. Ground water concentrations of 210Po in drilled wells might be as high as 6.5 Bq/l. But in regular drinking water it is just about 3-5

Mitral Valve Surgery: Effects on Cardiac Reverse Remodeling, Hemodynamics, and Clinical Outcome

Popular Abstract in Swedish Mitralisklaffen (lat. valva mitralis; valva bicuspidalis) är den klaff i hjärtat som finns mellan vänster förmak och vänster kammare. Till utseendet liknar klaffen påvens huvudbonad, mitra, varifrån namnet härstämmar. Mitralisklaffen består av två segelliknande flikar (klaffblad) med en upphängningsapparat som fäster sig i vänster-kammarens vägg. När vänster kammare konNormalization of life expectancy after mitral valve surgery is highly dependent on early diagnosis and referral for surgical treatment. Among cases treated surgically, the majority (60–70%) have a degenerative etiology, which is also easiest to repair. The general aim of this thesis was to bring research on treatment of degenerative mitral regurgitation a step further in order to improve clinical

Patients in court-ordered substance abuse treatment. Studies in the involuntary process by interview, assessment and randomised trial.

Commitment to involuntary care is a multistage process comprising many different aspects; legal, psychological, medical, social and ethical among others. It can also be analyzed from the perspective of a continuum starting from the report to the social authorities, the evaluations on whether to commit or not, the actual commitment and aftercare following involuntary treatment. Enhancing knowledge

Electron Transport in Quantum Dots Defined in Low-Dimensional Semiconductor Structures

Popular Abstract in Swedish I denna avhandling studeras ledningsförmågan hos nanometer-stora kvantprickar tillverkade i halvledarmaterial. Halvledare är material vars ledningsförmåga ligger någonstans mellan ledare (metaller) och isolatorer. I halvledare kan ledningsförmågan ändras med elektriska fält, vilket har möjliggjort utvecklandet av halvledartransistorn. Utvecklandet av halvledartransistorThis thesis focuses on electron transport in single and double quantum dots defined in low-dimensional, narrow-band-gap III-V semiconductor materials. Fabrication schemes are presented for defining single and double quantum dots in lateral InGaAs/InP heterostructures, either by a combination of etching and local gating or solely by local top gating. The quantum dots are here electrostatically conf

Microclimate and Thermal Comfort of Urban Spaces in Hot Dry Damascus- Influence of urban design and planning regulations

The aim of this study is to develop better understanding of the relationship between microclimate and urban design in the hot dry city of Damascus. This is done by studying the impact of urban regulations on microclimate in different urban design patterns in modern Damascus. This study also investigates the behaviour of different thermal comfort indices to define the thermal comfort and acceptabil

Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum

BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes

Response to the Proposal for a Directive on Corporate Sustainability Due Diligence by Nordic and Baltic Company Law Scholars

On February 23, 2022, The EU Commission published its Proposal for a Directive of the European Parliament and of the Council on Corporate Sustainability Due Diligence and amending Directive (EU) 2019/1937 (“CSDDD” or “the Proposal”). The purpose of the Proposal, to further the “Union’s transition to a climate-neutral and green economy in line with the European Green Deal and in delivering on the U

Predicting the Energy Performance of Buildings : A Method using Probabilistic Risk Analysis for Data-driven Decision-support

Byggnaders energieffektivitet är ett fokusområde i arbetet med att minska klimatförändringarna, då byggnader står för cirka 40 procent av den totala energianvändningen i Europeiska unionen. En lösning som tillämpas för att minska byggnaders energibehov är att ständigt införa strängare byggregler. Följaktligen ökar betydelsen av precisa och effektiva simuleringar för att kunna beräkna byggnaders frAs most countries worldwide continue to mitigate climate change, one area of focus is a building's energy efficiency. Buildings currently account for approximately 40 per cent of the total energy use in the European Union. One solution for reducing the energy demand from buildings is by continually implementing more stringent building regulations. Consequently, the importance of accurate and effic

Indoor to outdoor ratio of particle chemical components in an occupied residence

IntroductionConsidering that on average in developed countries we spend about 65% of our time in private homes, understanding the exposures in homes is of outmost importance. Aerosol concentrations indoors come from indoor sources, infiltrate from outdoors and can be formed from precursors both of indoor and outdoor origin. Several characteristics and processes influence the properties of aerosols

Peer Assisted Study Sessions (SI-PASS) in Higher Education, a European overview

The paper/presentation gives an overview of Peer-Assisted Study Schemes (SI-PASS) in Higher Education in Europe. SI-PASS is a method of improving student performance in “difficult” courses combining “how to learn” with “what to learn”. SI-PASS sessions are scheduled parallel to the regular education and are guided and facilitated by a “senior” student, the SI-PASS leader. The sessions are based on

Numerical modelling of geomaterials at failure

Geotechnical engineering is the science dealing with mechanics of soils and rocks and its engineering applications. Geotechnical engineering projects vary in a wide range, from evaluation of the stability of natural slopes and man-made soil deposits, to the design of earthworks and foundations. Traditional methods, using manual calculations or simplified computational methods, do not, as a rule, t