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Background Whole-genome sequencing (WGS) of heart transplant recipient- and donor-derived cardiac biopsies may facilitate organ matching, graft failure prediction, and immunotolerance research. The objective of this study was to determine the feasibility of WGS based on formalin-fixed paraffin-embedded endomyocardial biopsies. Methods and results The study included serial donor- and recipient samp

Introduction: The pulmonary oxygen uptake is reduced during apnea, compared to eupneic baseline, preserving the pulmonary oxygen store. This study elucidates the time course for this reduction, comparing it to the time course for apnea-induced cardiovascular responses. Methods and results: Experiments involved two groups, performing apneas during rest, both without and with cold-water face immersi

This study scans six decades of film history in search for video images, the imaginaries within which they are framed, and (taking cues from the archaeological methods of Friedrich Kittler and Michel Foucault) their technical, historical, and institutional conditions of existence. The British experimental science fiction film Anti-Clock (Jane Arden and Jack Bond, 1979) revolves around a video devi

Cardiovascular (CV) morbidity and mortality is high in patients with chronic kidney disease (CKD). Most patients reveal a high prevalence of CV risk factors such as diabetes or arterial hypertension and many have manifest cardiovascular disease (CVD), such as coronary artery disease and chronic heart failure with an increased risk of clinical events including sudden cardiac death. Diabetes mellitu

Externally bonded reinforcement (EBR) was used to increase load bearing capacity of light weight aggregate concrete (LWA) masonry walls subjected to eccentric axial compression. Ladder type masonry reinforcement, high strength steel wire strips and glass fiber mesh were used for strengthening of eleven, 2.4 m high, 0.5 m long and 0.1 m thick walls. The reinforcement was applied on the dry wall sur

Objectives: The aim of this study was to investigate genetic outcomes, analyze the family experience, and describe the process of implementing genetic sequencing for children with profound sensorineural hearing loss (SNHL) at a tertial audiological center in southern Sweden. Design: This is a prospective pilot study including eleven children with profound bilateral SNHL who underwent cochlear impl

The incidence of Human Papillomavirus positive (HPV+) tonsillar cancer has been sharply rising during the last two decades. Myeloid cells represent an appropriate therapeutic target due to their ability to orchestrate antigen-specific immunity within the tonsil, the availability of viral antigens, and the proximity of the tumor and the underlying lymphoid tissue. However, the interrelationship of

Our book has taken a distinctive, policy-oriented approach to IGR in analysing both specific crisis-driven problems and new, longer-term, and emerging policy issues confronting European governments. We have explored the shifting balances of power within IGR systems focused on the challenges of vertical and horizontal coordination within cross-country, comparative perspectives. In order to position

Non-traditional stable isotope systems are increasingly used to study micronutrient cycling and acquisition in terrestrial ecosystems. We previously proposed for zinc (Zn) a conceptual model linking observed isotope signatures and fractionations to biogeochemical processes occurring in the rice soil environment and we suggested that 2’deoxymugineic acid (DMA) could play an important role for rice

In order to study the influence of the hypothalamic-pituitary-adrenal axis on the levels of endogenous digitalis-like substances (EDLS) in plasma and urine, eight healthy subjects (25-40 years old) were given dexamethasone 1 mg orally and tetracosactide (an ACTH analog) 0.25 mg i.v., on separate occasions. The circulating levels of EDLS, TSH, PRL and AVP following administration of either test dru

There have been previous studies comparing experimental methods for the purpose of capturing gaseous yields at a range of global equivalence ratios. However, no work has investigated the capability of the open controlled atmosphere cone calorimeter for collecting such data where its two modes of operation are directly compared. The aim of this study is to compare carbon monoxide yields collected u

Chondrocytes isolated from the Swarm rat chondrosarcoma were incubated in culture with [1-3H]glucose for 30 min to 8 h. Labeled proteoglycans were isolated, treated with borohydride under alkaline conditions, and the three complex sugar structures purified: N- and O-linked oligosaccharides and chondroitin sulfate chains. The amount of incorporated radioactivity into each component sugar was analyz

Popular Abstract in Swedish För att tillverka en pappersbaserad förpackning är det viktigt att materialet är tillräckligt hållfast. Förpackningsmaterial består ofta av kartong, aluminium och polymerfilmer där kartong utgör den största delen av förpackningen och bidrar mest till styvheten. Det säljs årligen mer än hundra miljarder förpackningar i världen och om kostnaden samt materi- alåtgång för aContinuum based elasto-plastic-damage models for paperboard have been established in this work. The thesis begins with an introductory section that describes the mechanical properties of paperboard and some of the converting processes during forming of a package. A short review of modeling concepts that have been applied to paperboard is presented and then some key aspects and assumptions develope

Objectives. The treatment of eating disorders is a complex process that relies not only on the use of psychotropic drugs but should include also nutritional counselling, psychotherapy and the treatment of the medical complications, where they are present. In this review recommendations for the pharmacological treatment of eating disorders (anorexia nervosa (AN), bulimia nervosa (BN), binge eating

We celebrate Certec’s 20th birthday . . . . . . by giving you a book of 20 important ideas filled with pictures and text. Each idea is expressed in a succinct heading that sums up what we have learned over the years. The ideas also act as a complement to all the reports, website cover pages, brochures, lectures and annual reports. There are 30,000 documents at www.certec.lth.se that provide the b

Popular Abstract in Swedish Snabba fenomen, som inträffar efter laserexcitation, har studerats med tidsupplöst röntgendiffraktion (TXRD). I de flesta experimenten har en ljuspuls från en femtosekundlaser använts för att excitera provet, och dynamiken har undersökts med röntgenljus. Tidsupplösta röntgendiffraktionsmätningar har utförts för att studera fasta halvledarmaterial, vätskor, ferro-elektriFast phenomena occurring after laser excitation were studied using time-resolved X-ray diffraction (TXRD). In most experiments, a femtosecond laser pulse was used to excite the sample, and X-rays were used as a probe. The X-ray diffraction technique was used to study bulk semiconductor samples, molten liquids, ferro-electric domain switching in potassium dihydrogen phosphate (KDP), and strain prop

We argue that it is not too early to begin the planning process for a next generation neutron source for Europe, even as the European Spallation Source is being constructed. We put forward three main arguments. Firstly, nowadays the period between the first scientific concept of a new facility being proposed and its actual realisation is approaching half a century. We show evidence for this. Secon

In order to assess the non-evaporative components of the reduced thermal insulation of wet clothing, experiments were performed with a manikin and with human subjects in which two layers of underwear separated by an impermeable barrier were worn under an impermeable overgarment at 20 °C, 80% RH and 0.5 ms-1 air velocity. By comparing manikin measurements with dry and wetted mid underwear layer, th

Abstract in Undetermined Previous work has presented contrasting views of the last glaciation on Jameson Land, central East Greenland, and still there is debate about whether the area was: (i) ice-free, (ii) covered with a local non-erosive ice cap(s), or (iii) overridden by the Greenland Ice Sheet during the Last Glacial Maximum (LGM). Here, we use cosmogenic exposure ages from erratics to reconc