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Popular Abstract in Swedish Cellerna i kroppen är uppbyggda av fyra olika byggstenar: DNA, proteiner, fetter samt kolhydrater. Kolhydrater förknippas framförallt med energi och det pågår en intensiv debatt om kolhydraternas vara eller icke vara i vår kost. Kolhydraterna har dock också en helt annan funktion, en som är obestridligt oumbärlig för alla levande organismer. I denna roll förekommer de bGalectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now suggests important roles of galectins in both cancer and inflammation. The aim of this project is to get a c

Helsingborg, a coastal city in southern Sweden, initiated a long-term redevelopment project called H+ in 2009, aiming to convert industrial harbor space in the city's south into a new, livable urban neighborhood and city center. The project aims to create an open and ‘tolerant city’ in Helsingborg over the next twenty years. In 2010-2011, H+ used an open-source planning method as a strategy to inc

Popular Abstract in Swedish De flesta cancerpatienter dör på grund av spridning av tumörceller till olika organ. Invasiv och metastaserande cancer svarar ofta inte på behandling och blir då i många fall dödlig. Leukemi är en elakartad sjukdom av blodceller, som påverkar blod-producerande organ. Den höga förekomsten av leukemi förekommer i äldre befolkningen och hos barn. Leukemi återfall och resiThe majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. Elevated expression of a cell cycle regulator cyclin A1 initiated leukemia

Popular Abstract in Swedish Pankreascancer (cancer i bukspottkörteln) utgör fjärde orsak död i cancer. Det är den cancerform som har den dystraste prognosen av alla, med en 5-års överlevnad mindre än 6%. Sjukdomsrelaterade symptom uppträder ofta sent i förloppet och det saknas metoder för tidig diagnos varför de flesta av patienterna upptäckts i sent skede. Endast cirka 20 procent av patienterna kPancreatic cancer (PC) is the fourth leading cause of cancer-related deaths, with a 5-year survival less than 6%. It does not show any symptoms in its early stages, hence most (>85%) of the patients are diagnosed at late stage. At the time of diagnosis, metastases are frequently observed which make most patients unsuitable for curative surgical treatment and chemotherapy remains the only choice fo

Individual forager behaviors should affect per capita intake rates and thereby population and consumer-resource properties. We consider and incorporate conspecific facilitation and interference during the separate foraging-cycle stages in a functional response model that links individual behavioral interactions with consumer-resource processes. Our analyses suggest that failing to properly conside

Adsorption of mixed polymer solutions in good solvent containing polymers of different chain length has been studied by applying simulation techniques on a coarse-grained bead-spring polymer model. Fully flexible polymers at varying bead-surface interaction strength and different combinations of flexible, semiflexible, and stiff polymers at a single bead-surface interaction strength have been exam

Protein dynamics on the microsecond-millisecond time scales often play a critical role in biological function. NMR relaxation dispersion experiments are powerful approaches for investigating biologically relevant dynamics with site-specific resolution, as shown by a growing number of publications on enzyme catalysis, protein folding, ligand binding, and allostery. To date, the majority of studies

Among the numerous point vapor sources, microsecond-pulsed spark ablation at atmospheric pressure is a versatile and environmentally friendly method for producing ultrapure inorganic nanoparticles ranging from singlets having sizes smaller than 1 nm to larger agglomerated structures. Due to its fast quenching and extremely high supersaturation, coagulational growth already begins at the atomic sca

Molecular spiders are synthetic biomolecular walkers that use the asymmetry resulting from cleavage of their tracks to bias the direction of their stepping motion. Using Monte Carlo simulations that implement the Gillespie algorithm, we investigate the dependence of the biased motion of molecular spiders, along with binding time and processivity, on tunable experimental parameters, such as number

This paper reports on a joint numerical and experimental investigation of the release of potassium from biomass during gasification process. In this work, laser-induced breakdown spectroscopy (LIBS) was adopted to measure quantitatively the concentration of potassium from gasifying biomass. The effect of temperature on the potassium release is investigated in hot gas mixture of CO2, H2O with diffe

This paper contains a joint ESHG/ASHG position document with recommendations regarding responsible innovation in prenatal screening with non-invasive prenatal testing (NIPT). By virtue of its greater accuracy and safety with respect to prenatal screening for common autosomal aneuploidies, NIPT has the potential of helping the practice better achieve its aim of facilitating autonomous reproductive

Coordinated Multi Point (CoMP) transmission and reception techniques are used in order to improve the performance of single or multiple cells in wireless systems. A system using CoMP techniques is capable of jointly optimizing its transmission and/or reception and, hence, achieving higher performance. In this work, performance evaluation of three CoMP techniques are performed based on simulations

Den här avhandlingen kombinerar vetenskapen om komplexa adaptiva system med ekonomiska geografi för att beskriva och undersöka självorganiserande principer och drag i täta urbana ekonomier, särskilt med avseende på flöden av information och kunskap mellan människor som ger upphov till produktivitetsrelaterade externaliteter. Avhandlingen består av en kappa som presenterar det övergripande ramverkeThis doctoral thesis combines complexity science and economic geography in order to explore bottom-up, self-organizing principles within urban economies, in particular in relation to the flow of information and knowledge between people. The thesis consists of a kappa that covers the general theoretical framework and four papers. The papers cover urban scaling and intra-urban scaling analysis, loca

BackgroundEven though the importance of a facilitator during an implementation process is well described, the facilitator’s role is rarely problematized in relation to the organizational context in terms of power and legitimacy; themes which have recently been brought to the fore when studying change in health care organizations. Therefore, in this article, we present a qualitative study with the

The influence of external nitrogen (N) on carbon (C) allocation and processes related to phosphorus (P) metabolism were studied in monoxenic arbuscular mycorrhiza (AM) cultures of Daucus carota. Fungal hyphae of Glomus intraradices proliferated from colonized roots growing on solid medium into C-free liquid minimal medium with two different N and P levels. Furthermore, we exposed the colonized roo

This thesis has been taking a starting point from a micro-level that focuses social structures, ethnic segregation and processes of development as phenomena from different levels of perspectives. The research focuses on housing-conditions in the urban room and take a starting-point in 1992 when an increased number of immigrant households, depending on social welfare, moved into Herrgården (Manor-H

The emergence of new modes of production, referred to as flexible specialization, post-Fordism or neo-Fordism, has played an important and controversial role in the debate among economic geographers and industrial sociologists. In the discussion assumptions have been made about a process of up-skilling of the work force. In this study a random sample of 351 white- and blue-collar workers in eight