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Pancreatic cancer – Influence of Tumour Microenvironment

Popular Abstract in Swedish Pankreascancer (cancer i bukspottkörteln) utgör fjärde orsak död i cancer. Det är den cancerform som har den dystraste prognosen av alla, med en 5-års överlevnad mindre än 6%. Sjukdomsrelaterade symptom uppträder ofta sent i förloppet och det saknas metoder för tidig diagnos varför de flesta av patienterna upptäckts i sent skede. Endast cirka 20 procent av patienterna kPancreatic cancer (PC) is the fourth leading cause of cancer-related deaths, with a 5-year survival less than 6%. It does not show any symptoms in its early stages, hence most (>85%) of the patients are diagnosed at late stage. At the time of diagnosis, metastases are frequently observed which make most patients unsuitable for curative surgical treatment and chemotherapy remains the only choice fo

Modeling of soot formation during partial oxidation of producer gas

Soot formation in a reverse-flow partial-oxidation reactor for reforming of gasifier producer gas has been studied. The process was modeled using a detailed reaction mechanism to describe the kinetics of soot formation. The numerical model was validated against experimental data from the literature and showed good agreement with reported data. Nine cases with different gas compositions were simula

Multiplicity dependence of jet-like two-particle correlation structures in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 < p(T),(assoc) < p(T),(trig) < 5.0 GeV/c is examined, to include correlations induced by jets originating from low momentum-transfer scatterings (minijets). The

Deployment of Open Source ERPs: What Knowledge Does It Require?

Abstract in UndeterminedEnterprise resource planning (ERP) systems are rapidly becoming a de facto standard in business activity. While large and medium-sized companies have the luxury to afford proprietary ERP solutions, small companies are struggling with resource poverty which maybe makes them consider available open source ERP products which are free from licensing fee. However, there is littl

Gjutet med god leveransprecision!? - En studie i hur låg leveransprecision från leverantör påverkar produktionen på ITT Flygt AB

Problem discussion: The internal foundry of ITT Flygt occasionally has problems with on-time delivery to the product workshops. This could lead to extra costs regarding labour and stock keeping. ITT Flygt are today unaware of the extent of these costs. Objectives: The main objective of the master thesis is to investigate the effects of low delivery accuracy from the foundry to PVC. This main objec

Utveckling, anpassning eller maktkamp? - En studie av svensk krisberedskap

What causes changes in management? This thesis attempts to explain governmental change in the Swedish emergency management and at the same time determine how these changes can best be explained. The Swedish emergency management has been reorganized several times over the past 30 years and it’s these reorganizations that form the basis for this study. The study is based on three different organizat

Abstrakt normprövningsrätt – Normprövning i Sverige och i förhållande till unionsrättens krav på effektivt domstolsskydd

Den svenska normprövningsrätten bygger likt de flesta konstitutionella demokratier på en jämvikt mellan olika intressen. Lagstiftaren har i demokratier å ena sidan en skyldighet att fattat beslut som är förenliga med de formella krav som framgår av konstitutionen. Å andra sidan riskerar majoritetsstyre att kränka vissa fundamentala fri- och rättigheter för de minoriteter som inte står bakom en visThe Swedish system of judicial review, like most constitutional democracies, is based on an equilibrium between various interests. One the one hand, in democracies, the legislature are required to make decisions compatible with formal requirements in the constitution. On the other hand, majority rule can pose a threat against fundamental freedoms and rights. Individuals who might not agree with a

Challenging the Baath Party: A study of two episodes of popular contention in Syria

The authoritarian Ba?th regime in power in Syria since 1966 has been challenged twice by popular contention. In the first case, ?The Islamic rebellion?, the episode of contention erupted into violence, in the second case, ?The Damascus Spring?, it did not. In both cases the challengers changed strategies and methods of contention adapting to their counterparts and the external environment. This s

Designing for self-efficacy in a driving simulator: A pilot study

Virtual Reality and advanced, interactive simulators illustrate the potentials of modern technology for improving the ecological validity of learning experiments. Yet much more preliminary work is needed to appreciate how these growingly complex means can be utilized to promote high-order emotional and motivational constructs of the user, such as self-efficacy. Drawing from the frameworks of serio

Exploring the Cultural Trauma Theory

This is a study of the murder of the Swedish Prime Minister Olof Palme, not as it actually occurred, but rather how it was mediated through representations in the media. The guiding research question is formulated as follows: Can the media representations of the murder of Olof Palme be understood as a case of an emergent trauma process? These representations covers only the first week after the mu

Rule of law or judicial activism - two perspectives on the European Court of Justice

The role and activities of the European Court of Justice (EJC) have been discussed for couple of decades now. Without any doubt the role that ECJ fulfils today in the European Community is not what it was in the beginning of its existence and perhaps not even what was strictly prescribed by the EC Treaty. In the present thesis will be firstly examined, how the present role of the ECJ, as a quasi-c

Challenges and Responses to the Use of Targeted UN Sanctions

The United Nations (UN) sanctions regime was developed during the 1990's as an instrument to induce compliance with Security Council (SC) resolutions. The use of more comprehensive sanctions was criticised since it resulted in collateral damage including humanitarian distress. This brought Members of the UN to convene seminars where UN staff, academics and experts discussed how the sanctions r

Effects of various coolants on flow and heat transfer characteristics in a round-tip pin-finned internal channel

This paper performs a numerical study regarding the effects of different kinds of coolants on flow and heat transfer in a pin-finned internal channel. A new pin-fin structure detached from one endwall with a round-tip is proposed which aims to increase the heat transfer enhancement. As a contrast, the investigation of the typical fully-attached pin-fin and the flat-tip detached pin-fin is also con

Deep learning takes the pain out of back breaking work - Automatic vertebral segmentation and attenuation measurement for osteoporosis

Background: Osteoporosis is an underdiagnosed and undertreated disease worldwide. Recent studies have highlighted the use of simple vertebral trabecular attenuation values for opportunistic osteoporosis screening. Meanwhile, machine learning has been used to accurately segment large parts of the human skeleton. Purpose: To evaluate a fully automated deep learning-based method for lumbar vertebral

Biogenic carbon dioxide as feedstock for production of chemicals and fuels : A techno-economic assessment with a European perspective

The use of fossil resources must be phased out during the next few decades in order to meet the adopted 2° target. The transition to non-fossil feedstocks in the production of chemicals and transportation fuels will make it increasingly important to economise on the biomass carbon since biomass is a limited resource. Carbon dioxide (CO2) can be used as carbon feedstock and thus serve as a valuable

Preferences for improvements in attributes associated with basal insulin : a time trade-off and willingness-to-pay survey of a diabetic and non-diabetic population in Sweden

Objective: Apart from improved health outcomes, treatment convenience per se may have a value to individuals. This is sometimes referred to as process utility and can be estimated in terms of willingness-to-pay (WTP) or quality-adjusted life-years (QALYs). Previous research has produced multiple studies on QALY gains and WTP estimates of insulin-related attributes. There are, however, significant

PPC operation with low ron gasoline fuel. A study on load range on a euro 6 light duty diesel engine

Gasoline Partially Premixed Combustion (PPC) is a promising alternative combustion concept that can offer both high indicated efficiency and low exhaust emissions in terms of NOx and soot, compared to conventional diesel combustion (CDC). Previous research has shown that PPC can operate with gasoline-like fuels of varying RON numbers. Some of the most promising results come with the use of gasolin

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Through significant developments and progresses in the last two decades, in vivo localized nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain metabolic pathways in a non-invasive way. Beside the measurement of the total concentration of more than 20 metabolites, (1)H MRS can be used to quantify the dynamics of substrate transport across the blood-brain barrier b