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The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo
Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topo
Several previous studies have demonstrated that severe hypoglycemia is accompanied by consumption of endogenous brain substrates (glycolytic and citric acid cycle metabolites and free amino acids) and some have shown a loss of structural components as well, notably phospholipids. In the present study, on paralysed and artificially ventilated rats, we measured cerebral oxygen and glucose consumptio
OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx insulin diabetes management system (iDMS). RESEARCH DESIGN AND METHODS - in this randomized, open-label, four-period crossover, glucose clamp study 23 nonsmoking subjects with type I diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either
Background: Physiologically guided revascularization improves clinical outcomes. The cutoff values for deferral with fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the same across all coronary arteries, despite differences in coronary flow patterns. The objective was to compare deferral rates using either FFR or iFR in the right coronary artery (RCA), left anterior desce
Background Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity; however, it remains unclear whether the apnea–hypopnea index (AHI) or the severity of nocturnal hypoxemia, in terms of oxygen desaturation index (ODI), is more relevant for the development of heart failure (HF). Methods We included 3590 participants from the Sleep Apnea Patients in Skaraborg Study (mean age 54.6
Differences in ecological conditions can result in the evolution of dramatic inter-population shifts in whole suites of traits. We studied variation in reproductive output in three lizard populations of the Skyros Wall Lizard (Podarcis gaigeae, Lacertidae) endemic to the Skyros Archipelago (Greece), which live under similar climatic conditions but differ in predation pressure and food availability
Popular Abstract in Swedish Parksinson’s sjukdom (PD) är en neurodegenerativ sjukdom där dopamininnehållande (dopaminerga) nervceller gradvis dör av oklar anledning, vilket leder till störningar I rörelsemönstret hos patienten. Det finns för närvarande inte någon bot mot sjukdomen och de goda effekterna av medicinering avtar efter 5-10 år. Genom att transplantera nya dopaminerga nervceller från hTransplantation of embryonic dopaminergic neurones can ameliorate symptoms in Parkinson’s disease, but a major obstacle for clinical transplantations to overcome is the low survival (typically 5-10%) of implanted nigral neurones. If cell death in nigral grafts can be prevented, less embryonic tissue would be needed per transplantation session and hence more patients could receive intracerebral gra
We have engineered apolipoprotein A-I (apoA-I), a major protein constituent of high-density lipoprotein (HDL), to contain DOTA-chelated Gd(III) as an MRI contrast agent for the purpose of imaging reconstituted HDL (rHDL) biodistribution, metabolism and regulation in vivo. This protein contrast agent was obtained by attaching the thiol-reactive Gd[MTS-ADO3A] label at Cys residues replaced at four d
When an excess of human cystatin C or chicken cystatin was mixed with papain, an enzyme-inhibitor complex was formed immediately. The residual free cystatin was then progressively converted to a form with different electrophoretic mobility and chromatographic properties. The modified cystatins were isolated and sequenced, showing that there had been cleavage of a single peptide bond in each molecu
Aims Cardiac Resynchronization Therapy (CRT) reduces morbidity and mortality for patients with heart failure and wide QRS complex, but up to 1/3 of patients are "non-responders" to the therapy. This study examines the ability of a simple standard electrocardiogram (ECG)-based scoring system to predict clinical outcome. Methods and results Four hundred and ninety-one consecutive patients with CRT
Aims: Bacterial infection is a major challenge in wound care. Antimicrobial wound dressings are of great value for treating wound infections. Endolysins are evolving as a new class of antimicrobials with multiple applications. This study describes the production and evaluation of T4 lysozyme (T4Lyz), product of gene e of the T4 bacteriophage, fused with Cellulose Binding Module (CBM) for facile im
This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lea
Background: Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal thyroid function can result in adverse pregnancy and child developmental outcomes, there is still uncertainty whether bisphenols or triclosan can interfere with thyroid function during pregnancy. Objectives: We aimed to investigate the association of urinary bisphenol A (BPA), bi
Background: Although sugar consumption has been associated with several risk factors for cardiometabolic diseases, evidence for harmful long-term effects is lacking. In addition, most studies have focused on sugar-sweetened beverages (SSBs), not sugar per se. Objective: The aim of this study was to examine the associations between added and free sugar intake, intake of different sugar sources, a
Objective: The phase IIIb OPINION trial (NCT03402841) investigated olaparib maintenance monotherapy in patients without a deleterious or suspected deleterious germline BRCA1/BRCA2 mutation (gBRCAm) who had platinum-sensitive relapsed ovarian cancer (PSROC) and had received ≥2 previous lines of platinum-based chemotherapy. Methods: In this single-arm, open-label, international study, patients who h
PURPOSE In the randomized open-label phase III OVHIPEC trial, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery (CRS) improved recurrence-free and overall survival in patients with stage III ovarian cancer. We studied the cost effectiveness of the addition of HIPEC to interval CRS in patients with ovarian cancer. PATIENTS AND METHODS We constructed
Regeringsformen (RF) 2 kap. 1 § ger inte tydlig ledning i fråga om vad som utgör legitima inskränkningar av yttrandefriheten. Lagtextens vaga utform-ning, samt skiftande praxis i förhållande till bestämmelsen gör det komplicerat att bestämma yttrandefrihetens omfattning i svensk rätt. Problematiken gör sig gällande i fråga om förhållandet till legitima inskränkningar, såsom bestäm-melsen om hets mThe second chapter, section 1 of the instrument of Government does not pro-vide a clear interpretation of what constitutes legitimate restrictions on free-dom of expression. This causes issues concerning the interpretation of free-dom of expression in Swedish law. The vague legal text, along with varying practices in relation to the provision, result in uncertainty regarding the extent of the free
Ceremony 1998 Sune Svanberg Atomfysik, LTH LLC/LUMLAC Lunds Universitet LUMLAC: www.mlc.lu.se BIOFOTONIK I LUND http://www5.lu.se/upload/GrafiskProfil/Logotyper/Lunds_universitet_C2r.zip Analytical Chemistry Review by Lund University Researchers (1989) Lund Laser Medicine Group 1983 - Medical Laser Centre 1991 - Appl. Spectr. 1984 Optics Lett. 1985 1990 LUMLAC Proposal Present biophotonics in Lund
https://www.mlc.lu.se/fileadmin/mlc/Minnesanteckningar/Biofotonik_Sune_Svanberg.pdf - 2026-06-29
TREIJIJEBORG *tt' a Ehrenbus ch. Àlbäckafrurro Trelleborgs kopparport aJ. K:rös, tiggare oo origina.I. Sota¡e 31om - tiggare. And,ers .A¡aclersson - original. Magi vid köp av grisar. Stå1. vid ba¡nclop. Fjäragillen och. skatgillen. övernaturliga väsen. Orättrådiga lantnätare gick igen. 9 sorters träd. mot sjukclom. Röke]-se. Stöpa bI¡r. Îa psalnêr¡ Yita kIädningar vicl konfi.matiorren. BruùdrËikt
https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/stadstrad/Trelleborg.pdf - 2026-06-29
