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A common challenge in the development of new drug substances is poor dissolution characteristics caused by low aqueous solubility. In this study, microcrystals with optimized physicochemical properties were prepared by precipitation in the presence of excipients, which adsorbed to the particle surface and altered particle size, morphology, and dissolution rate. The poorly water-soluble drug sirame

Solid dispersions are promising drug delivery forms which offer the possibility to disperse a hydrophobic drug in a hydrophilic matrix and thereby improve the dissolution behavior and the bioavailability of the drug. One important aspect and a prerequisite in understanding the drug dissolution mechanism from solid dispersions is a better analytical monitoring of the solid dispersion surface proper

The objective of this study was to investigate the swelling characteristics of a hydroxypropyl methylcellulose (HPMC) matrix incorporating the hydrophilic drug antipyrine. We have used this matrix to introduce a novel analytical method, which allows us to obtain within one experimental setup information about the molecular processes of the polymer carrier and its impact on drug release. Nuclear ma

I denna artikel undersöks hur omställningen till distansundervisning i svenska gymnasieskolor i samband med coronapandemin påverkade lärare och förutsättningarna för deras pedagogiska uppdrag. Fokus i artikeln ligger på lärares upplevelser av sitt arbete och hur deras lärarvardag i flera avseenden kom att negeras under pandemin, vilket också kom att innebära att delvis omedvetna föreställningar om

This article discusses a concept that institutions from the OECD to the EU increasingly employ in their response to the ecological crisis: The bioeconomy, wherein materials for economic activity would be bio-based and renewable. As a present-day project, the bioeconomy translates the critique of (fossil) carbon into patterns of (material) resource use and (economic) resource allocation, not least

We present novel approaches involving generative adversarial networks and diffusion models in order to synthesize high-quality, live, and spoof fingerprint images while preserving features such as uniqueness and diversity. We generate live fingerprints from noise with a variety of methods, and we use image translation techniques to translate live fingerprint images to spoof. To generate different

The last several years of research, including children followed from birth and extensive genetic studies, have resulted in a paradigm shift of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM). Autoimmune T1DM is characterized by the appearance in early childhood of a first β-cell autoantibody against either insulin (IAA) or GAD65 (GADA), or both. The genetic etiology is strongly as

Despite the numerous cultural networks within and outside of European contexts of culture-led urban development as well as transnational cultural policy-making, in-depth analyses of such networks remain scarce. In light of this, the article introduces the network Trans Europe Halles (TEH, est. 1983) as an empirical case study that illustrates cultural grassroots organising across its 165+ members

This article explores the development process of a sharing platform in the tourism industry, drawing on a longitudinal case study of a sharing-based business in adventure tourism in Sweden. The purpose is to explore how sharing business models emerge through processes of ideological narration—the strategic use of stories to shape and sustain a business. Over a two-year period, empirical data were

We address two research applications in this methodological review: starting from an audio recording, the goal may be to characterize nonlinear phenomena (NLP) at the level of voice production or to test their perceptual effects on listeners. A crucial prerequisite for this work is the ability to detect NLP in acoustic signals, which can then be correlated with biologically relevant information ab

Nonlinear phenomena (NLP) are often associated with high arousal and function to grab attention and/or signal urgency in vocalizations such as distress calls. Although biomechanical models and in vivo/ex vivo experiments suggest that their occurrence reflects the destabilization of vocal fold vibration under intense subglottal pressure and muscle tension, comprehensive descriptions of the dynamics

At some point in our evolutionary history, humans lost vocal membranes and air sacs, representing an unexpected simplification of the vocal apparatus relative to other great apes. One hypothesis is that these simplifications represent anatomical adaptations for speech because a simpler larynx provides a suitably stable and tonal vocal source with fewer nonlinear vocal phenomena (NLP). The key assu

Nonlinear phenomena (NLP) are acoustic irregularities that are widespread in animal and human vocal repertoires, as well as in music. These phenomena have recently attracted considerable interest but, surprisingly, have never been the subject of a comprehensive review. NLP result from irregular sound production, contribute to perceptual harshness, and have long been considered nonadaptive vocal fe

This paper aims to identify micro-level processes shaping the narratives surrounding regional opportunity spaces. A process perspective is applied to examine how place leaders engage in shaping narratives to influence the perception of opportunity spaces. The empirical research is based on a comparative case study of four peripheral regions in Germany, comprising 92 interviews with regional stakeh

Regional diversification has been positioned as a topic of great interest among researchers of economic geography, however, there remain some research gaps that must be attended to. Through the use of complex networks analysis from this literature in a period from 1975 to 2022, we identify some methodological and theoretical issues related to its measurement methods, the lack of an integrative fra