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Recent genome-wide association studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases, as a type 2 diabetes (T2D) risk gene. Here, we reveal that Dusp8 is a gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans. Male, but not female, Dusp8 loss-of-function mice, either with global or corticotropin-releasing ho

Mot bakgrund av den nuvarande och framtida kompetensbrist som kännetecknar offentlig sektor, syftar föreliggande studie till att bidra till såväl forskning som praktik genom sitt fokusera på talangförsörjning. Studien har koncentrerats dels kring två frågor: 1. Hur använder sig ett antal av Skånes offentliga organisationer av HR-driven talent management för sin talangförsörjning? 2. Hur använder s

We take a fresh look at Feynman diagrams in the spinor-helicity formalism. Focusing on tree-level massless QED and QCD, we develop a new and conceptually simple graphical method for their calculation. In this pictorial method, which we dub the chirality-flow formalism, Feynman diagrams are directly represented in terms of chirality-flow lines corresponding to spinor inner products, without the nee

Baserat på ett empiriskt material som består av enkätsvar och intervjuer samt kompletterande dokumentgranskning från landets samtliga 21 landsting och regioner(endast dokumentgranskning i två fall) tar sig den här rapporten an två syften: Att ge en heltäckande bild av de modeller för styrning, inklusive ersättningsmodeller,som tillämpas i svensk primärvård samt en analys av dessa med utgångspunkt

Det övergripande syftet i denna studie är attjämföra och analysera skillnader och likheter mellan att leda i kommunal och icke-kommunal regi för rektorer i gymnasieskolan och enhetschefer för äldreboenden. Ambitionen ärockså att beskriva hur kraven fördessa två chefskategorier har förändratssedanbörjan av 1990-talet samt vad i omvärlden som för närvarande påverkar deras situation som ledare och ch

The aethalometer model has shown to offer a fast, inexpensive and robust method for source apportionment. The method relies on aerosol light absorption attribution, mass balance of the total carbon and results in a fraction of unaccounted, residual carbon that has been associated to biogenic carbon due to its presumably non-light absorbing properties. This residual carbon and its relation to trace

The North Atlantic Oscillation (NAO) has been hypothesized to drive interannual variability in Bermudan coral extension rates and reef-scale calcification through the provisioning of nutritional pulses associated with negative NAO winters. However, the direct influence of the NAO on Bermudan coral calcification rates remains to be determined and may vary between species and reef sites owing to imp

Justice is an underlying principle and an important lens in understanding sustainable development goals (SDG). There is a need for analysis and clarification on the underlying principles of justice embedded in the SDGs. Goals such as no poverty (goal 1), zero hunger (goal 2), health and well-being (goal 3), gender equality (goal 5), affordable energy (goal 7), reduced inequalities (goal 10) as wel

As the COVID-19 pandemic intensified the global health crisis, the containment of SARS-CoV-2 infection in pregnancies, and the inherent risk of vertical transmission of virus from mother-to-fetus (or neonate) poses a major concern. Most COVID-19-Pregnancy patients showed mild to moderate COVID-19 pneumonia with no pregnancy loss and no congenital transmission of the virus; however, an increase in

Type 2 diabetes, characterized by dysfunction of pancreatic β-cells and insulin resistance in peripheral organs, accounts for more than 90% of all diabetes. Despite current developments of new drugs and strategies to prevent/treat diabetes, there is no ideal therapy targeting all aspects of the disease. Restoration, however, of insulin-producing β-cells, as well as insulin-responsive cells, would