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Single-cell and single-nuclei RNA-sequencing (scRNA-seq and snRNA-seq) analyze cell-specific transcriptomes. However, only snRNA-seq applies to frozen biobanked samples. For human pancreatic islets, marker genes and reference-based cell type annotation methods are mainly from scRNA-seq datasets and may not be suitable for snRNA-seq. We compared human islet scRNA-seq and snRNA-seq data from the sam

Försörjningsberedskap är återigen centralt för Sverige och man inser att samhällsviktiga försörjningskedjor består av såväl olika slags myndigheter som privata, ofta globala, företag. För att höja beredskap, behövs ett mer gemensamt arbete med risker och kontinuitetshantering i försörjningskedjor. Det finnas dock stora samverkansutmaningar i detta privat-offentliga gränssnitt. Artikeln beskriver e

Municipal currencies are emerging as policy tools for fostering local economies and enhancing human rights, as illustrated by the cases of Mumbuca in Maricá, Brazil, and Vilawatt in Viladecans, Spain. These local currencies address socio-economic and environmental challenges by articulating currency issuance with community priorities, such as social welfare or reducing energy poverty. Unlike natio

Multiple myeloma (MM) is the second most common hematological malignancy, characterized by clonal proliferation of neoplastic plasma cells in the bone marrow, causing hematopoietic suppression and impaired antibody production. Bacterial infections remains a major cause of mortality in MM. As in in most malignancies, myeloma cells modify their microenvironment to promote tumor growth, including sup

Battery cell assembly and testing in conventional battery research is acknowledged to be heavily time-consuming and often suffers from large cell-to-cell variations. Manual battery cell assembly and electrolyte formulations are prone to introducing errors which confound optimization strategies and upscaling. Herein we present ODACell, an automated electrolyte formulation and battery assembly setup

The urgent need for improving the energy density of aqueous lithium ion batteries (ALIBs) can be addressed by the implementation of advanced electrode materials and electrolytes. The utilization of layered oxide cathodes, particularly Li[NixCoyMnz]O2 (NCM) materials, is an effective strategy, as they can offer high specific capacities in an appropriate voltage range. However, due to the strong eff

Li-rich layered oxides are considered as one of the most promising cathode materials for secondary lithium batteries due to their high specific capacities, but the issue of continuous voltage decay during cycling hinders their market entry. Increasing the Ni content in Li-rich materials is assumed to be an effective way to address this issue and attracts recent research interests. However, a high

This study evaluates the design choices of a two-day, industry-collaborative case competition at Campus Helsingborg and their effect on student motivation and engagement. Using pre and post Self-Determination Theory surveys, observations, and interviews we observed very high intrinsic (4.82/5) and extrinsic motivation (4.33/5). The perceived value of competition elements increased consistently aft

Background: The association between socioeconomic status (SES) and environmental burden is context-dependent. Those with low SES may be more likely to live near major roads and industries where environmental exposures are high but may also be more likely to live further away from city centers. The aim of this study was to investigate the association between SES and environmental burden in Sweden.

En kortlek med 67 situationskort för universell utformning för lärande (UDL) utvecklades vid fyra internationella lärarworkshops för att hjälpa lärare att förstå och förbättra inkluderande undervisning, dvs. att vara proaktiva och förberedda på en mångfald av studenter. De utskrivna korten har hämtats eller beställts av cirka 150 personer. Denna artikel presenterar resultaten av en enkät som skickA deck of 67 context cards for Universal Design for Learning (UDL) was developed at four international teacher workshops, to help teachers understand and improve inclusive teaching, i.e. to be proactive and prepared for student diversity. The printed cards have been picked up or ordered by approximately 150 people. This paper presents the results of a questionnaire sent to 44 people.The results fr

The traditional approaches rely solely on temperature measures to assess heat-related health risks; but there is a growing trend towards using bio-meteorological indices for a more comprehensive evaluation. However, the adoption of bio-meteorological indices in developing countries is considerably limited. Therefore, this study compares bio-meteorological index, the maximum Universal Thermal Clima

Changes in functional connectivity (FC) strength involving the medial temporal lobe (MTL) and posteromedial cortex (PMC) are related to early Alzheimer’s pathology and alterations in episodic memory performance in cognitively unimpaired older adults, but their dynamics remain unclear. We examined how longitudinal changes in FC involving MTL and PMC during resting-state, episodic memory encoding, a

The morphogenetic protein DivIVA exhibits diverse functions across bacterial phyla. In Bacillota, DivIVA is primarily involved in cell division, whereas in Actinomycetota, it plays a central role in coordinating polar growth. Due to its essentiality in Actinomycetota, gaining insight into its structural functions is challenging. We studied truncated DivIVA proteins using a unique divIVA deletion m

Aerosol surface composition plays a critical role in atmospheric chemistry but remains poorly characterized, especially for inorganic systems lacking organic surfactants. While bulk composition is typically measured, key interfacial processes, including heterogeneous reactions, water uptake, and cloud activation, occur at the surface. Here, we present the first depth-resolved, in-flight X-ray phot

Objectives We aimed to describe clinical and diagnostic characteristics of primary care patients with heart failure and physicians’ adherence to guideline-directed medical therapy (GDMT) for treating chronic heart failure. Design Cross-sectional study based on baseline data from the prospective primary care-based study Heart failure in Southern Sweden (HISS). Setting Patients with heart failure we

Betulin is a natural pentacyclic triterpene, and is contained in birch tree, especially its outer bark. Betulin can be used as a hydrophobic building block for production of biobased surfactants. This invention is related to amphiphilic betulin derivatives, and their efficient production method. And resulting materials can be used as biobased surfactants.

The present invention relates to an amphipathic compound, a preparation method therefor, and a surfactant composition comprising same and, specifically, to a compound selected from the group consisting of steviol monoglycoside-acid, steviol monoglycoside-ester, and steviol monoglycoside-amide, a preparation method therefor, and a surfactant composition comprising at least one of these compounds.

A search for R-parity-violating supersymmetry in final states with high jet multiplicity is presented. The search uses 140 fb−1 of proton-proton collision data at s = 13 TeV collected by the ATLAS experiment during Run 2 of the Large Hadron Collider. The results are interpreted in the context of R-parity-violating supersymmetry models that feature prompt gluino-pair production decaying directly to

The integration of machine learning (ML) into software operations (MLOps) has significantly increased the demand for data to train and test models, making data sharing and reuse essential to mitigate the high costs of data collection and preprocessing. This study aims to advance the understanding of data sharing within an MLOps context by examining the establishment and governance of a data ecosys

Introduction Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often termed treatment-resistant depression (TRD) and is seen in over one-Third of people with MDD. Reasons for treatment resistance are not well established, nor is the definition of TRD. Duration and se