Allergic contact dermatitis (ACD) initiated by chemical sensitizers is an important public health concern. To prevent ACD, it is important to identify chemical allergens to limit the use of such compounds in various products. EU legislations, as well as increased mechanistic knowledge of skin sensitization have promoted development of non-animal based approaches for hazard classification of chemic

Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear. Herein, we have investigated platelet activation in a mouse model of invasive Streptococcus pyogenes infection at 5,12, and 18 hours post infection and correlated this to parameters of infection. The platelet population in ex-

In this study we conceptualise how a capability approach could be used for analysing the conditions for preserving security of energy supply. We derive a concept, ‘energy system capability’, to describe how well the system is designed for this purpose. Based on a socio-technical systems perspective, we suggest that this capability is composed of five categories of ‘building blocks’: technical stru

The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethionine (dcAdoMet) to putrescine or to spermidine to form spermidine or spermine, respectively. In an effort to understand why efficient inhibitors of PfSpdS have be

Why is there hunger in sub-Saharan Africa? What forces drive the global food system? What is the global food system? To approach these questions, this study investigates power and politics in food, in its production and in its organization. Proceeding from a critical realist approach, focus of this study is on the challenge of African smallholder food insecurity and how it is presented as part of

Anthropologists have a long history talking about what we should do when we research less powerful or subordinate groups. We build rapport, we give them voice, we describe their world to others, we show their problems and their solutions. We have a kind of solidarity with them. But more of us are now researching groups with autonomous resources and power. I myself have been with NGO elites, planne

Solid Oxide Fuel Cells (SOFCs) are widely studied for their advantages specially at high temperatures. The microscopic chemical reactions that occur in the cells have a strong influence on the cell performance although not much research has been done in this field yet. In order to do so, a numerical model of the microstructure of the electrodes, where the reactions take place, is needed. Different