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We analyzed the morphology and the transcriptomic changes of human neural stem progenitor cells (hNSPCs) grown on laminin in adherent culture conditions and subjected to simulated microgravity for different times in a random positioning machine apparatus. Low-cell-density cultures exposed to simulated microgravity for 24 h showed cell aggregate formation and significant modulation of several genes

First Published in 1991. This is Volume 13 in a series of Transportation Studies. It contains 2 parts of the proceedings of a Conference held at Stockholmsmassan, Alvsjo, Sweden, 21-24 May 1989, organized by the Swedish Board of Transport in co-operation with the Department of Traffic Planning and Engineering, Lund Institute of Technology.

The role of public transport in society is crucial, particularly for those who do not have access to alternative transport modes. For public transport to be able to fulfil its societal role, it should not be perceived as unsafe or unhealthy by its (potential) users. Several studies from all over the world have shown that anxiety has increased remarkably during the pandemic, and it is likely to las

Interferon gamma (IFNγ) is central to the inflammatory immune response, such as that entrained by BCG immunotherapy for bladder cancer. However, immune-mediated tumour cell killing is subject to modulation by immunoinhibitory “checkpoint” receptors such as PD-L1. We investigated the effects of IFNγ on barrier-forming in vitro-differentiated normal human urothelium using mRNA-sequencing, and showed

Normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from healthy donors preferentially inhibit T helper 1 (Th1) cells and investigated the myeloid-derived suppressive effect in different T-cell populations. We found that NDG-induced suppression of T-cell proliferation was co

Recent research in motion event typology has moved beyond the binary Talmian division of "verb-framed" and "satellite-framed" languages and has established the existence of at least four distinct typological clusters, instantiated by, for example, Swedish (Germanic), French (Romance), Thai (Tai-Kadai) and Telugu (Dravidian). In this paper, we focus on characteristic features of Telugu, as a repres

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1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav

Resurrection studies can answer some fundamental questions in aquatic ecology and evolutionary biology. For phytoplankton resting stages, longevity of thousands to millions of years has recently been reported. However, contamination during sediment sampling could distort these estimates, and this risk has not been systematically evaluated. Here we used 4.5 μm diameter microspheres to quantify cont

BACKGROUND: Emergency computed tomography angiography (CTA) is the most important imaging modality to visualize arterial occlusions in patients with acute lower limb ischaemia (ALI). Extravascular incidental findings (EVIFs) have received less attention.PURPOSE: The aims of this study were to evaluate the incidence of EVIFs of immediate clinical relevance in patients with ALI undergoing CTA and ev

BackgroundPatients with substance use disorder (SUD) suffer from excess mortality compared to the overall population. This study aims to identify patterns in death rates among patients with SUD visiting a SUD emergency ward and to explore whether this knowledge can be used as input to identify patients at risk and increase patient safety.MethodsHospital visit data to a SUD emergency ward were coll

OBJECTIVE: To investigate the value of ultrasonographic data in predicting total knee replacement (TKR).DESIGN: Data from the Musculoskeletal Pain in Ullensaker study (MUST) was linked to the Norwegian Arthroplasty Register to form a 5-7 year prospective cohort study of 630 persons (69% women, mean (SD) age 64 (8.7) years). We examined the predictive power of ultrasound (US) features, i.e. osteoph

Decarbonizing society will require a shift toward renewable electricity production. However, the temporal configuration of renewables requires that demand adapt accordingly. Introducing intermittent electricity production will thus require end users to be more flexible in their use of electricity. Flexibility capital has been promoted as a concept for analyzing material preconditions in order to u

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered effo

Increased salinity is one of the major consequences of climatic change affecting global crop production. The early stages in the barley (Hordeum vulgare L.) life cycle are considered the most critical phases due to their contributions to final crop yield. Particularly, the germination and seedling development are sensitive to numerous environmental stresses, especially soil salinity. In this study