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Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are approved for the treatment of type 2 diabetes, obesity, and related conditions, and have demonstrated significant benefits for individuals with these conditions. However, in recent years, public interest and demand for GLP-1RAs-often driven by media, social media influencers, advertising, and public disco
BACKGROUND: Weight-related bias, stigma, and discrimination significantly affect quality of life and health in persons with obesity. Their influence on post-operative outcomes following metabolic surgery and bariatric remains underexplored.OBJECTIVES: This systematic review aimed to evaluate any impact of pre- and post-operative weight bias, stigma, and discrimination on post-metabolic and bariatr
The preterite-present verb (ge)munan, meaning ‘to remember’ or ‘to be mentally active’, is attested throughout the Old English period (450-1150). Deriving from the Proto-Germanic preterite-present lexical verb munan, it belongs to a class of verbs many of which grammaticalised into modal auxiliaries during Old and Middle English. (Ge)munan itself appears to have undergone grammaticalisation, as su
This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reportin
Food intake induces metabolic and hemodynamic changes, but its impact on many circulating protein biomarkers remains unclear. This study assessed the effect of a standardised meal on 85 plasma biomarkers measured by the Proseek Multiplex Metabolism panel. Twenty-two healthy adults (11 men, 11 women; mean age 25.9 ± 4.2 years) were examined after an overnight fast and at 30 and 120 min following
BACKGROUND: Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor in adults. While immune evasion is a well-recognized driver of GBM progression and a major obstacle for efficient immunotherapy, the role of the complement system remains underexplored. C1-inhibitor (C1-INH), a regulator of complement activation, was recently found overexpressed in GBM. We therefore hypothesized
We consider two optimization problems in which a planner aims to influence the average transient opinion in the Friedkin-Johnsen dynamics on a network by intervening on the agents' innate opinions. Solving these problems requires full network knowledge, which is often not available because of the cost involved in collecting this information or due to privacy considerations. For this reason, we foc
Structured Abstract Background Sexual health and functioning are significant, yet often overlooked, components of psychosocial well-being of adults with congenital heart disease (ACHD). Prior research reports inconsistent findings, limited data on older adults with CHD, and few studies have compared patients with controls from the general population. This study investigated sexual functioning in m
Trots att det är ett fundamentalt begrepp inom global hälsa och utveckling är det förvånansvärt svårt att fånga vad solidaritet innebär. Denna artikel börjar med en diskussion av vad som karakteriserar solidaritet, inklusive uppfattade och verkliga spänningar mellan egenintresse och solidaritet inom internationellt bistånd. Därvid bygger den på illustrativa exempel ur historien om svenskt bistånd,Although it is a fundamental concept in global health and development, soli-darity is surprisingly hard to capture. This essay first discusses characteris-tics of solidarity, including perceived and real tensions between self-interest and solidarity in international aid. In doing so, it draws upon illustrative ex-amples from Sweden’s aid history, as well as international vaccine solidarity during
Although it is a fundamental concept in global health and development, soli-darity is surprisingly hard to capture. This essay first discusses characteris-tics of solidarity, including perceived and real tensions between self-interest and solidarity in international aid. In doing so, it draws upon illustrative ex-amples from Sweden’s aid history, as well as international vaccine solidarity during
This chapter reviews the imaging findings of different non-infectious inflammatory diseases that affect the central nervous system, with special emphasis on demyelinating disorders, such as multiple sclerosis, neuromyelitis optica and acute disseminated encephalomyelitis. Special sections are also dedicated to inflammatory vascular disorders and to metabolic and toxic conditions that affect the ad
In their seminal hypothesis, Hamilton and Zuk proposed parasites to drive host sexual selection and predicted infections to correlate with ornamentation. Since then, a plethora of studies has explored how parasite occurrence relates to host traits, though the underlying assumption that parasite infection parameters are host-specific traits has rarely been evaluated. We used a global database (MalA
Bakgrund/Syfte: Inom allmänpsykiatrin i Sverige behandlas personer med komplexa psykiatriska behov. Det innebär bland annat begränsningar i att delta i vardagens aktiviteter och samhällslivet. Att få stöd med detta kan möjliggöra ett liv värt att leva trots psykisk ohälsa, i enlighet med arbetsterapi. Flexible Assertive Community Treatment (FACT) är en återhämtningsinriktad integrerad vård- och st
The contact urticaria syndrome (CUS) shows four stages of severity. It is a syndrome that initially involves the skin but also the respiratory or the gastrointestinal tract once it has manifested systemically. It is potentially a life-threatening syndrome. Immediate contact skin reactions (ICSR) induced by environmental agents are clinical manifestations of contact urticaria (CoU) and protein cont
